公开(公告)号：US20230165795A1

公开(公告)日：2023-06-01

申请号：US16982990

申请日：2019-03-20

Applicant: Universiteit Twente

Inventor： Jai Prakash ,  Peter Van Hoogevest ,  Gerrit Storm

IPC: A61K9/127 ,  A61K38/05 ,  A61K38/21 ,  A61K47/40

CPC classification number: A61K9/127 ,  A61K38/05 ,  A61K38/217 ,  A61K47/40

Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.

公开(公告)号：US12156938B2

公开(公告)日：2024-12-03

申请号：US16982990

申请日：2019-03-20

Applicant: Universiteit Twente

Inventor： Jai Prakash ,  Peter Van Hoogevest ,  Gerrit Storm

IPC: A61K9/127 ,  A61K38/05 ,  A61K38/21 ,  A61K47/40

Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.