公开(公告)号：US20210369632A1

公开(公告)日：2021-12-02

申请号：US17332258

申请日：2021-05-27

Applicant: University of Connecticut

Inventor： Raman Bahal ,  Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Shipra Malik

IPC: A61K9/51 ,  A61K47/42 ,  A61K47/26

Abstract: A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle.

公开(公告)号：US11760966B2

公开(公告)日：2023-09-19

申请号：US16899676

申请日：2020-06-12

Applicant: University of Connecticut

Inventor： Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Reza Amin ,  Leila Daneshmandi

IPC: C12M3/06 ,  C12N5/00 ,  G01N33/50 ,  C12M1/34 ,  C12M1/12

CPC classification number: C12M23/16 ,  C12M25/16 ,  C12M41/46 ,  C12N5/0012 ,  G01N33/5008

Abstract: Described herein are apparata and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.

公开(公告)号：US20240067911A1

公开(公告)日：2024-02-29

申请号：US18364999

申请日：2023-08-03

Applicant: University of Connecticut

Inventor： Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Reza Amin ,  Leila Daneshmandi

IPC: C12M3/06 ,  C12N5/00 ,  G01N33/50 ,  C12M1/34 ,  C12M1/12

CPC classification number: C12M23/16 ,  C12N5/0012 ,  G01N33/5008 ,  C12M41/46 ,  C12M25/16

Abstract: Described herein are apparati and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.

公开(公告)号：US11833254B2

公开(公告)日：2023-12-05

申请号：US17332258

申请日：2021-05-27

Applicant: University of Connecticut

Inventor： Raman Bahal ,  Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Shipra Malik

IPC: A61K9/127 ,  A61K9/51 ,  A61K47/24 ,  A61K47/34 ,  A61K47/26 ,  A61K47/42 ,  A61K9/14

CPC classification number: A61K9/5123 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/146 ,  A61K9/5146 ,  A61K9/5192 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42

Abstract: A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle.

公开(公告)号：US12227726B2

公开(公告)日：2025-02-18

申请号：US18364999

申请日：2023-08-03

Applicant: University of Connecticut

Inventor： Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Reza Amin ,  Leila Daneshmandi

IPC: C12M3/06 ,  C12M1/12 ,  C12M1/34 ,  C12N5/00 ,  G01N33/50

Abstract: Described herein are apparati and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.