公开(公告)号：US20230270554A1

公开(公告)日：2023-08-31

申请号：US18142238

申请日：2023-05-02

Applicant: University of Connecticut

Inventor： Thanh Duc Nguyen ,  Ritopa Das

IPC: A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/38

CPC classification number: A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/3847 ,  A61L2430/02 ,  A61F2002/2864 ,  A61F2002/2821 ,  A61F2002/30062

Abstract: A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.

公开(公告)号：US11678989B2

公开(公告)日：2023-06-20

申请号：US16806902

申请日：2020-03-02

Applicant: University of Connecticut

Inventor： Thanh Duc Nguyen ,  Ritopa Das

IPC: A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/38 ,  A61F2/30

CPC classification number: A61F2/28 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/2821 ,  A61F2002/2864 ,  A61F2002/30062 ,  A61F2002/3084 ,  A61F2002/30087 ,  A61F2002/30677 ,  A61F2002/30971 ,  A61L2400/12 ,  A61L2430/02

Abstract: A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.

公开(公告)号：US20210378949A1

公开(公告)日：2021-12-09

申请号：US17342470

申请日：2021-06-08

Applicant: University of Connecticut

Inventor： Thanh Duc Nguyen ,  Eli Curry ,  Ritopa Das ,  Yang Liu

IPC: A61K9/00 ,  H01L41/45 ,  A61L15/42 ,  A61K9/70 ,  A61L15/64 ,  A61L15/26 ,  C08L67/04

Abstract: Methods, systems, and apparatus, including combination therapy systems for the treatment of infections. These systems comprising: an ultrasound device capable of producing ultrasonic acoustic pressure; and a biodegradable piezoelectric film comprising polymer-based piezoelectric material, poly(L-lactic acid) (PLLA) nanofiber mesh configured to, when placed in an electrolytically conductive environment comprising water and stimulated with the ultrasonic acoustic pressure, vibrate generating electricity to locally decomposes the water into reactive oxygen species (ROS) to induce a broad-spectrum bactericidal effect.

公开(公告)号：US20200276018A1

公开(公告)日：2020-09-03

申请号：US16806902

申请日：2020-03-02

Applicant: University of Connecticut

Inventor： Thanh Duc Nguyen ,  Ritopa Das

IPC: A61F2/28 ,  A61L27/38 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54

Abstract: A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.