公开(公告)号：US20220355089A1

公开(公告)日：2022-11-10

申请号：US17871490

申请日：2022-07-22

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US11426570B2

公开(公告)日：2022-08-30

申请号：US16293588

申请日：2019-03-05

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US20190269895A1

公开(公告)日：2019-09-05

申请号：US16293588

申请日：2019-03-05

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US20220096371A1

公开(公告)日：2022-03-31

申请号：US17487661

申请日：2021-09-28

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Nicholas Farrell

IPC: A61K9/00 ,  C08G63/08 ,  A61K45/06

Abstract: A transdermal, biodegradable microneedle system and method for treating pain in a patient. The transdermal easy-to-use biodegradable microneedle system can be fully embedded into the skin to perform a sustained and nearly zero-order release kinetics of therapeutics over a long period of time (at least 30 days) for the treatment of pain.