公开(公告)号：US20240197865A1

公开(公告)日：2024-06-20

申请号：US18556668

申请日：2022-04-22

Applicant: University of Saskatchewan

Inventor： Sylvia Van Den Hurk ,  Volker Gerdts ,  Robert Brownlie ,  Ravendra Garg

IPC: A61K39/295 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/005

CPC classification number: A61K39/295 ,  A61K39/39 ,  A61P37/04 ,  C07K14/005 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6018 ,  A61K2039/70 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18622 ,  C12N2760/18634

Abstract: The present invention provides immunogenic chimeric respiratory syncytial virus (RSV)-parainfluenza virus type 3 (PIV3) compounds and associated compositions, along with methods of treating, preventing and/or diagnosing RSV- and PIV3-related disorders.

公开(公告)号：US20230218734A1

公开(公告)日：2023-07-13

申请号：US17996688

申请日：2021-04-19

Applicant: University of Saskatchewan ,  The University of British Columbia

Inventor： Antonio Facciuolo ,  Philip Griebel ,  Volker Gerdts ,  Andrew Potter ,  Neil Rawlyk ,  Jeffrey Chen ,  Elodie Pastural ,  Manjeet Bains ,  Michael Trimble ,  Amy Lee ,  Robert Hancock

IPC: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/569

CPC classification number: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/5695 ,  A61K2039/55566

Abstract: Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.

公开(公告)号：US20210267890A1

公开(公告)日：2021-09-02

申请号：US17276649

申请日：2019-09-20

Applicant: University of Saskatchewan

Inventor： Ellen K. Wasan ,  Kishor M. Wasan ,  Volker Gerdts ,  Stacy Strom

IPC: A61K9/127 ,  A61K39/39 ,  A61K9/00

Abstract: Methods and compositions for enhancing an immune response, such as a mucosal immune response, to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites.

公开(公告)号：US09408908B2

公开(公告)日：2016-08-09

申请号：US13768694

申请日：2013-02-15

Applicant: University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

Inventor： Sylvia van den Hurk ,  Volker Gerdts ,  Andrew Potter ,  Lorne Babiuk ,  Robert Hancock ,  Scott Halperin ,  Jennifer Kovacs-Nolan ,  George Mutwiri ,  Song Lee ,  Mi-Na Kweon ,  Jason Kindrachuk ,  Melissa Elliott

IPC: A61K39/39 ,  A61K39/12 ,  A61K47/30 ,  A61K45/06 ,  A61K39/155 ,  C07K7/08 ,  A61K39/02 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

公开(公告)号：US20140248313A1

公开(公告)日：2014-09-04

申请号：US13768694

申请日：2013-02-15

Applicant: University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

Inventor： Sylvia van den Hurk ,  Volker Gerdts ,  Andrew Potter ,  Lorne Babiuk ,  Robert Hancock ,  Scott Halperin ,  Jennifer Kovacs-Nolan ,  George Mutwiri ,  Song Lee ,  Mi-Na Kweon ,  Jason Kindrachuk ,  Melissa Elliott

IPC: A61K39/39 ,  A61K45/06 ,  A61K47/30 ,  A61K39/155

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract translation: 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。

公开(公告)号：US12268734B2

公开(公告)日：2025-04-08

申请号：US17156477

申请日：2021-01-22

Applicant: University of Saskatchewan ,  Kenya Agriculture and Livestock Research Organization (KALRO) ,  International Livestock Research Institute (ILRI)

Inventor： Andrew Potter ,  Volker Gerdts ,  Jose Perez-Casal ,  Yejun Wang ,  Hezron Wesonga ,  Reuben Soi ,  Jan Naessens ,  Joerg Jores

IPC: A61K39/02 ,  A61K39/00 ,  A61P31/04 ,  C07K14/30 ,  C12N15/62

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

公开(公告)号：US20240199663A1

公开(公告)日：2024-06-20

申请号：US18556667

申请日：2022-04-22

Applicant: University of Saskatchewan ,  Battelle Energy Alliance, LLC

Inventor： Samuel Attah-Poku ,  George Mutwiri ,  Sylvia Van Den Hurk ,  Jan Van Den Hurk ,  John Klaehn ,  Volker Gerdts

IPC: C07F9/6593 ,  A61K39/00 ,  A61K39/39

CPC classification number: C07F9/65815 ,  A61K39/39 ,  A61K2039/55511

Abstract: Disclosed herein are cyclopolyphosphazenes of formula I:




methods for the preparation thereof and uses thereof in adjuvant compositions.