公开(公告)号：WO2010122222A3

公开(公告)日：2010-12-16

申请号：PCT/FI2010050318

申请日：2010-04-20

Applicant: VALTION TEKNILLINEN ,  FENG GAO ,  KIIHAMAEKI JYRKI ,  HOKKANEN ARI ,  HEIMALA PAEIVI

Inventor： FENG GAO ,  KIIHAMAEKI JYRKI ,  HOKKANEN ARI ,  HEIMALA PAEIVI

IPC: A61M37/00 ,  B81C1/00

CPC classification number: A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150511 ,  A61B5/15142 ,  A61B2562/0295 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061

Abstract: The application relates to microfluidic needles and their manufacturing methods. The microfluidic needle comprises an interface portion containing at least one fluid communication channel, an elongated needle portion (40) projecting away from the interface portion (44), the needle portion having a tip and sidewalls connecting the tip to the interface portion, and at least two microfluidic channels (43 A-B) within the needle portion in fluidic connection with the at least one communication channel, the microfluidic channels being at least partly oriented parallel to the elongated needle portion. According to the application, the microfluidic channels exit the needle portion at the sidewalls of the needle portion. The needle may be fabricated by ALD-assisted silicon micromachining. The needle can be used for injection and/or sampling fluids to/from tissue or individual cells.

Abstract translation: 本申请涉及微流体针及其制造方法。 所述微流体针包括含有至少一个流体连通通道的界面部分，远离所述界面部分（44）突出的细长针部分（40），所述针部分具有将尖端连接到界面部分的尖端和侧壁， 在所述针部分内与所述至少一个连通通道流体连接的至少两个微流体通道（43AB），所述微流体通道至少部分地定向为平行于所述细长针部分。 根据应用，微流体通道在针部分的侧壁处离开针部分。 针可以通过ALD辅助的硅微加工制造。 针可以用于向组织或单个细胞注射和/或取样流体。

公开(公告)号：WO2010133771A3

公开(公告)日：2011-04-07

申请号：PCT/FI2010050410

申请日：2010-05-21

Applicant: VALTION TEKNILLINEN ,  PITKAENEN JUHA-PEKKA ,  HOKKANEN ARI ,  HEIMALA PAEIVI ,  KAUHANIEMI JARI ,  KOLARI KAI ,  SAVOLAHTI PEKKA ,  UUSITALO JAANA

Inventor： PITKAENEN JUHA-PEKKA ,  HOKKANEN ARI ,  HEIMALA PAEIVI ,  KAUHANIEMI JARI ,  KOLARI KAI ,  SAVOLAHTI PEKKA ,  UUSITALO JAANA

IPC: C12M1/26 ,  B01D33/01 ,  B01D35/02 ,  G01N1/20

CPC classification number: G01N1/2035 ,  C12M33/04 ,  C12M33/14 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: The invention relates to a sample port, filter, and sampling method. The sample port according to the invention comprises a body (10) equipped with an internal cavity (11) and two plungers (21,32) arranged moveably in this, which can be pressed against each other in the internal cavity, in order to compress a sample, and at least one of which plungers can be moved into a reactor, in order to collect a sample. The sample port also comprises a sample chamber, which is formed by the space remaining between the internal cavity and the plungers, and at least one sample-container connection (12) connected in connection with the internal cavity, in order to collect the sample from sample chamber. In addition, the sample port has filter means adapted to at least either plunger for separating the liquid component of the sample from the solid component and means (31,40) for leading the liquid component of the sample out of the sample chamber.

Abstract translation: 本发明涉及采样端口，滤波器和采样方法。 根据本发明的采样端口包括配备有内部空腔（11）的主体（10）和可移动地布置在其中的两个柱塞（21,32），其可在内部空腔中彼此挤压，以便压缩 样品，并且其中至少一个柱塞可以移动到反应器中，以便收集样品。 样品端口还包括样品室，其由残留在内腔和柱塞之间的空间形成，以及至少一个与内腔连接的样品容器连接件（12），以便将样品从 样品室。 此外，样品端口具有适于至少用于将样品的液体组分与固体组分分离的柱塞的过滤装置和用于将样品的液体组分引导出样品室的装置（31,40）。

公开(公告)号：FI20095568A

公开(公告)日：2010-11-23

申请号：FI20095568

申请日：2009-05-22

Applicant: VALTION TEKNILLINEN

Inventor： PITKAENEN JUHA-PEKKA ,  HOKKANEN ARI ,  HEIMALA PAEIVI ,  KAUHANIEMI JARI ,  KOLARI KAI ,  SAVOLAHTI PEKKA ,  UUSITALO JAANA

IPC: B01L20060101

Abstract: A sample port includes a body equipped with an internal cavity and two plungers arranged moveably in the internal cavity, whereby the plungers can be pressed against each other in the internal cavity, in order to compress a sample. At least one of the plungers can be moved into a reactor in order to collect a sample. The sample port also includes a sample chamber, which is formed by a space remaining between the internal cavity and the plungers. At least one sample-container connection is connected in connection with the internal cavity in order to collect the sample from sample chamber. In addition, the sample port has a filter which is provided to at least either plunger for separating a liquid component of the sample from a solid component and means for leading the liquid component of the sample out of the sample chamber.

公开(公告)号：FI20095432A0

公开(公告)日：2009-04-20

申请号：FI20095432

申请日：2009-04-20

Applicant: VALTION TEKNILLINEN

Inventor： HOKKANEN ARI ,  KAENSAEKOSKI MARKKU ,  HEIMALA PAEIVI

IPC: G01N20090101

公开(公告)号：FI20095568A0

公开(公告)日：2009-05-22

申请号：FI20095568

申请日：2009-05-22

Applicant: VALTION TEKNILLINEN

Inventor： PITKAENEN JUHA-PEKKA ,  HOKKANEN ARI ,  HEIMALA PAEIVI ,  KAUHANIEMI JARI ,  KOLARI KAI ,  SAVOLAHTI PEKKA ,  UUSITALO JAANA

IPC: B01L20090101

Abstract: A sample port includes a body equipped with an internal cavity and two plungers arranged moveably in the internal cavity, whereby the plungers can be pressed against each other in the internal cavity, in order to compress a sample. At least one of the plungers can be moved into a reactor in order to collect a sample. The sample port also includes a sample chamber, which is formed by a space remaining between the internal cavity and the plungers. At least one sample-container connection is connected in connection with the internal cavity in order to collect the sample from sample chamber. In addition, the sample port has a filter which is provided to at least either plunger for separating a liquid component of the sample from a solid component and means for leading the liquid component of the sample out of the sample chamber.

公开(公告)号：FI20095433A0

公开(公告)日：2009-04-20

申请号：FI20095433

申请日：2009-04-20

Applicant: VALTION TEKNILLINEN

Inventor： FENG GAO ,  KIIHAMAEKI JYRKI ,  HOKKANEN ARI ,  HEIMALA PAEIVI

IPC: A61M20090101