公开(公告)号：WO1996039076A1

公开(公告)日：1996-12-12

申请号：PCT/US1996008876

申请日：1996-06-05

Applicant: VANDERBILT UNIVERSITY

Inventor： VANDERBILT UNIVERSITY ,  RICHARDS, William, O. ,  WIKSWO, John, P., Jr. ,  STATTON, Daniel, J. ,  GOLZARIAN, Javad ,  BRADSHAW, Leonard, A.

IPC: A61B05/05

CPC classification number: A61B5/42 ,  A61B5/04005 ,  A61B5/4255

Abstract: Intestinal ischemia is diagnosed non-invasively by scanning the abdomen (7) externally with a SQUID magnetometer (9) which measures the magnetic field (5) produced by smooth muscle electrical activity. These measurements are processed to determine the basic electrical rhythm (BER) frequency at various locations (43) along the intestine (1). A nominal value for the BER frequency is established at each location (43), and if the measured value falls below the associated nominal value by more than a predetermined margin, ischemia at that location is indicated. Ischemia is further indicated by an internal of arrhythmia in which the BER frequency increases to a range of about 24-180 cpm or at least about twice the nominal value. The BER frequency values are presented on a graphic display (39) which provides an indication of the nominal value at an affected location (43) from the gradient of the measured values at adjacent normal locations. Also, a gradual reduction in the local BER frequency at a particular location is an indication of progressive ischemia, while an absence of BER activity in a section of intestine (1) indicates necrosis.

Abstract translation: 通过用测量由平滑肌电活动产生的磁场（5）的SQUID磁力计（9）向外部扫描腹部（7），非侵入性地诊断肠缺血。 处理这些测量以确定沿着肠（1）的各个位置（43）处的基本电节律（BER）频率。 在每个位置（43）建立BER频率的标称值，如果测量值低于相关联的标称值超过预定的余量，则指示该位置处的缺血。 心律失常的内部进一步表示缺血，其中BER频率增加到约24-180cpm或至少约两倍标称值的范围。 BER频率值呈现在图形显示器（39）上，该图形显示器（39）根据相邻正常位置处的测量值的梯度提供受影响位置（43）处的标称值的指示。 此外，特定位置处的局部BER频率的逐渐降低是进行性缺血的指征，而在肠段（1）中没有BER活性指示坏死。