公开(公告)号：US20140140594A1

公开(公告)日：2014-05-22

申请号：US14085732

申请日：2013-11-20

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  The Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Holt Ginger ,  Isaac Pence

IPC: G01N33/483 ,  G06T7/00 ,  G01N21/27

CPC classification number: G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

Abstract: In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit a source light; at least one optical probe; a scanner; a spectrometer; and a controller coupled with the scanner and the spectrometer for operably controlling the scanner and the spectrometer. In operation, a working end of the optical probe is positioned proximate to a surface of a specimen of the tumor tissues. A source channel of the optical probe deliver the source light emitted by the light source from the working end to the surface of the specimen, and a plurality of collection channels collect from the working end diffused/reflected light generated from interaction of the source light with the specimen. The spectrometer receives the collected diffused/reflected light to evaluate a margin status of the specimen.

Abstract translation: 一方面，本发明涉及评价活体受试者的肿瘤组织的手术边缘的系统。 在一个实施例中，该系统包括配置成发射源光的光源; 至少一个光学探针; 扫描仪 光谱仪 以及与扫描器和光谱仪耦合的控制器，用于可操作地控制扫描仪和光谱仪。 在操作中，光学探针的工作端位于肿瘤组织样本的表面附近。 光学探针的源通道将光源发射的源光从工作端传送到样品的表面，并且多个收集通道从工作端收集由源光与光源的相互作用产生的漫射/反射光与 标本。 光谱仪接收收集的扩散/反射光，以评估样品的边缘状态。