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1.发明申请
公开(公告)号：WO0067764A3
公开(公告)日：2001-02-08
申请号：PCT/CA0000566
申请日：2000-05-08
Applicant: VASOGEN INC , BOLTON ANTHONY E
Inventor： BOLTON ANTHONY E
CPC classification number: A61M1/3681 , A61K35/14 , A61K41/0014 , A61M1/3683 , A61M1/3687 , A61M1/369 , A61M2205/053
Abstract: An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either being on consecutive days or being separated by a rest period of 1 to 21 days. The treatment is useful for treating or preventing a wide range of pathological conditions in which modified mammalian blood is effective, including preconditioning a mammalian subject to better withstand the adverse effects of ischemic stress, atherosclerosis and rheumatoid arthritis.
Abstract translation: 一种用于治疗或预防哺乳动物受试者的病理状况的改进方法，其中向受试者施用修饰的哺乳动物血液。 该方法包括向受试者施用二至四等份的修饰的哺乳动物血液，施用任何一对连续的处理或连续数天或分开1至21天的休息期。 该治疗可用于治疗或预防修饰的哺乳动物血液有效的广泛病理状况，包括预处理哺乳动物受试者以更好地抵御缺血性应激，动脉粥样硬化和类风湿性关节炎的不良作用。
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公开(公告)号：DK0680346T3
公开(公告)日：2002-10-28
申请号：DK93904180
申请日：1993-02-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: A method of increasing the nitric oxide concentration in the blood which comprises contacting blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation. Blood prepared by the method of the invention is used for treating a variety of conditions benefited by increased blood levels of nitric oxide.
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公开(公告)号：AT219953T
公开(公告)日：2002-07-15
申请号：AT93904180
申请日：1993-02-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: A method of increasing the nitric oxide concentration in the blood which comprises contacting blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation. Blood prepared by the method of the invention is used for treating a variety of conditions benefited by increased blood levels of nitric oxide.
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公开(公告)号：AU724265B2
公开(公告)日：2000-09-14
申请号：AU3844297
申请日：1997-08-11
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
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公开(公告)号：NZ306395A
公开(公告)日：2000-02-28
申请号：NZ30639596
申请日：1996-05-03
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E , COOKE ERNEST D
Abstract: Vasospastic disorders such as Raynaud's phenomenon are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's bloodstream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers, along with an enhancement of endothelial function in the patient. Divisional filed as 502504
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Patent Agency Ranking
公开(公告)号：AU4738500A
公开(公告)日：2000-11-21
申请号：AU4738500
申请日：2000-05-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either being on consecutive days or being separated by a rest period of 1 to 21 days. The treatment is useful for treating or preventing a wide range of pathological conditions in which modified mammalian blood is effective, including preconditioning a mammalian subject to better withstand the adverse effects of ischemic stress, atherosclerosis and rheumatoid arthritis.
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公开(公告)号：PT680346E
公开(公告)日：2002-10-31
申请号：PT93904180
申请日：1993-02-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: A method of increasing the nitric oxide concentration in the blood which comprises contacting blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation. Blood prepared by the method of the invention is used for treating a variety of conditions benefited by increased blood levels of nitric oxide.
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公开(公告)号：CA2263911A1
公开(公告)日：1998-02-26
申请号：CA2263911
申请日：1997-08-11
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia , leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
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公开(公告)号：CA2263911C
公开(公告)日：2007-01-16
申请号：CA2263911
申请日：1997-08-11
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia , leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
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公开(公告)号：CA2372624A1
公开(公告)日：2000-11-16
申请号：CA2372624
申请日：2000-05-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either being on consecutive days or being separated b y a rest period of 1 to 21 days. The treatment is useful for treating or preventing a wide range of pathological conditions in which modified mammali an blood is effective, including preconditioning a mammalian subject to better withstand the adverse effects of ischemic stress, atherosclerosis and rheumatoid arthritis.
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