Patent search ap:("VENTIRX PHARMACEUTICALS INC") AND inv:"HOWBERT JAMES JEFFRY" Page 1

1.

发明申请
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林

公开(公告)号：WO2011022508A2

公开(公告)日：2011-02-24

申请号：PCT/US2010045934

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10

CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。

2.

发明申请
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 取代的苯并吖庚因作为TOLL样受体调节剂

公开(公告)号：WO2012097173A3

公开(公告)日：2012-09-20

申请号：PCT/US2012021110

申请日：2012-01-12

Applicant: VENTIRX PHARMACEUTICALS INC , HOWBERT JAMES JEFFRY , HERSHBERG ROBERT

Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT

IPC: C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D403/10

CPC classification number: C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

Abstract translation: 提供了用于调节通过Toll样受体TLR7和/或TLR8的信号转导的组合物和方法。该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，传染病，炎症性疾病，移植排斥或移植物抗宿主疾病。

3.

发明申请
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林

公开(公告)号：WO2012097177A3

公开(公告)日：2012-10-26

申请号：PCT/US2012021116

申请日：2012-01-12

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , HERSHBERG ROBERT

Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT

IPC: C07D403/10 , A61K31/55 , A61P37/00 , C07D223/14 , C07D403/12

CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。

4.

发明申请
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林

公开(公告)号：WO2011022509A3

公开(公告)日：2011-06-16

申请号：PCT/US2010045935

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY

IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14

CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。

5.

发明公开
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 有权

公开(公告)号：EP2467377A4

公开(公告)日：2013-01-02

申请号：EP10810563

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10

CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10

6.

发明公开
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 有权
Title translation: 替代苯甲酸酯类似的类似物 - 调节剂

公开(公告)号：EP2663550A4

公开(公告)日：2014-07-16

申请号：EP12734770

申请日：2012-01-12

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA

Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , YANG HONG WOON

IPC: C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04

CPC classification number: C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04

Abstract: Provided are benzazepine derivatives useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The benzazepine derivatives have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

Abstract translation: 提供的组合物和方法可用于通过Toll样受体TLR7和/或TLR8调节信号传导。组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。

7.

发明专利
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 未知

公开(公告)号：CA2771484C

公开(公告)日：2019-01-15

申请号：CA2771484

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY

IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease. The provided compositions include (see above formula)