公开(公告)号：US20130131356A1

公开(公告)日：2013-05-23

申请号：US13735757

申请日：2013-01-07

Applicant: VERTEX PHAMACEUTICALS INCORPORATED

Inventor： WILLIAM A. NUGENT ,  Adam R. Looker ,  Raymond E. Forslund ,  Theodore A. Martinot ,  Cristian L. Harrison ,  Sheree Ibrahim

IPC: C07D339/06

CPC classification number: C07D339/06

Abstract: The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.

Abstract translation: 本发明提供β-砜酰胺α-酮酯和酰胺，其中α-酮被保护为1,3-二硫戊环衍生物。 还提供了制备这些酯和酰胺并将其并入肽中的方法。