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公开(公告)号：AP844A
公开(公告)日：2000-06-09
申请号：AP9700961
申请日：1997-01-24
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , SALITURO FRANCESCO GERALD , DEININGER DAVID D , BHISETTI GOVINDA RAO , BAKER CHRISTOPHER T , SPALTENSTEIN ANDREW , KAZMIERSKI WIESLAW MIECZYSLAW , ANDREWS III CLARENCE WEBSTER
IPC: C07D233/32 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4192 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5365 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61P31/00 , A61P31/18 , A61P43/00 , C07D207/26 , C07D207/27 , C07D207/36 , C07D209/54 , C07D233/36 , C07D241/06 , C07D241/36 , C07D265/28 , C07D265/32 , C07D265/34 , C07D275/02 , C07D285/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D513/04 , C07
Abstract: This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.
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公开(公告)号：NO20006405L
公开(公告)日：2001-02-19
申请号：NO20006405
申请日：2000-12-15
Applicant: VERTEX PHARMA
Inventor： SHERRILL RONALD GEORGE , HALE MICHAEL R , SPALTENSTEIN ANDREW , FURFINE ERIC STEVEN , ANDREWS III CLARENCE WEBSTER , LOWEN GREGORY THOMAS
IPC: A61P31/18 , C07C303/00 , C07C311/48 , C07C311/49 , C07D213/30 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D319/06 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561 , C07C
Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods For inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：NO20006405D0
公开(公告)日：2000-12-15
申请号：NO20006405
申请日：2000-12-15
Applicant: VERTEX PHARMA
Inventor： SHERRILL RONALD GEORGE , HALE MICHAEL R , SPALTENSTEIN ANDREW , FURFINE ERIC STEVEN , ANDREWS III CLARENCE WEBSTER , LOWEN GREGORY THOMAS
IPC: A61P31/18 , C07C303/00 , C07C311/48 , C07C311/49 , C07D213/30 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D319/06 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561 , B41J
Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods For inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：NO983435A
公开(公告)日：1998-09-21
申请号：NO983435
申请日：1998-07-24
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER DENNIS , SALITURO FRANCESCO GERALD , DEININGER DAVID D , BHISETTI GOVINDA RAO , BAKER CHRISTOPHER TODD , SPALTENSTEIN ANDREW , KAZMIERSKI WIESLAW M , ANDREWS III CLARENCE WEBSTER
IPC: C07D233/32 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4192 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5365 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61P31/00 , A61P31/18 , A61P43/00 , C07D207/26 , C07D207/27 , C07D207/36 , C07D209/54 , C07D233/36 , C07D241/06 , C07D241/36 , C07D265/28 , C07D265/32 , C07D265/34 , C07D275/02 , C07D285/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D513/04
CPC classification number: C07D207/27 , C07D233/36 , C07D265/32 , C07D265/34 , C07D285/10 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D491/10
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Patent Agency Ranking
公开(公告)号：NO20006405A
公开(公告)日：2001-02-19
申请号：NO20006405
申请日：2000-12-15
Applicant: VERTEX PHARMA
Inventor： SHERRILL RONALD GEORGE , HALE MICHAEL R , SPALTENSTEIN ANDREW , FURFINE ERIC STEVEN , ANDREWS III CLARENCE WEBSTER , LOWEN GREGORY THOMAS
IPC: A61P31/18 , C07C303/00 , C07C311/48 , C07C311/49 , C07D213/30 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D319/06 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561 , C07C
CPC classification number: C07D213/30 , C07C311/48 , C07C311/49 , C07C2601/08 , C07C2601/14 , C07D215/48 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D309/22 , C07D319/06 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561
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公开(公告)号：NO983435L
公开(公告)日：1998-09-21
申请号：NO983435
申请日：1998-07-24
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER DENNIS , SALITURO FRANCESCO GERALD , DEININGER DAVID D , BHISETTI GOVINDA RAO , BAKER CHRISTOPHER TODD , SPALTENSTEIN ANDREW , KAZMIERSKI WIESLAW M , ANDREWS III CLARENCE WEBSTER
IPC: C07D233/32 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4192 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5365 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61P31/00 , A61P31/18 , A61P43/00 , C07D207/26 , C07D207/27 , C07D207/36 , C07D209/54 , C07D233/36 , C07D241/06 , C07D241/36 , C07D265/28 , C07D265/32 , C07D265/34 , C07D275/02 , C07D285/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D513/04
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公开(公告)号：AP1717A
公开(公告)日：2007-01-30
申请号：AP2000002023
申请日：1999-06-17
Applicant: VERTEX PHARMA
Inventor： SHERRILL RONALD GEORGE , HALE MICHAEL R , SPALTENSTEIN ANDREW , FURFINE ERIC STEVEN , ANDREWS III CLARENCE WEBSTER , LOWEN GREGORY THOMAS
IPC: A61P31/18 , C07C303/00 , C07C311/48 , C07C311/49 , C07D213/30 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D319/06 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561
Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：AU2004200636A1
公开(公告)日：2004-03-11
申请号：AU2004200636
申请日：2004-02-19
Applicant: VERTEX PHARMA
Inventor： SHERRILL RONALD GEORGE , LOWEN GREGORY THOMAS , ANDREWS III CLARENCE WEBSTER , FURFINE ERIC , SPALTENSTEIN ANDREW , HALE MICHAEL R
IPC: A61P31/18 , C07C303/00 , C07C311/48 , C07C311/49 , C07D213/30 , C07D235/06 , C07D235/26 , C07D235/30 , C07D235/32 , C07D241/42 , C07D243/04 , C07D265/02 , C07D277/30 , C07D307/20 , C07D309/06 , C07D309/12 , C07D319/06 , C07D405/12 , C07D407/12 , C07D413/06 , C07D417/12 , C07D493/04 , C07F9/6561
Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods For inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：NO983435D0
公开(公告)日：1998-07-24
申请号：NO983435
申请日：1998-07-24
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER DENNIS , SALITURO FRANCESCO GERALD , DEININGER DAVID D , BHISETTI GOVINDA RAO , BAKER CHRISTOPHER TODD , SPALTENSTEIN ANDREW , KAZMIERSKI WIESLAW M , ANDREWS III CLARENCE WEBSTER
IPC: C07D233/32 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/403 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4192 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5365 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61P31/00 , A61P31/18 , A61P43/00 , C07D207/26 , C07D207/27 , C07D207/36 , C07D209/54 , C07D233/36 , C07D241/06 , C07D241/36 , C07D265/28 , C07D265/32 , C07D265/34 , C07D275/02 , C07D285/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D513/04 , C07D
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