公开(公告)号：PH12016501028A1

公开(公告)日：2016-07-04

申请号：PH12016501028

申请日：2016-06-01

Applicant: VERTEX PHARMA

Inventor： COREY ANDERSON ,  SABINA HADIDA-RUAH SARA ,  CHARLES GOLEC JULIAN MARIAN ,  BEILI ZHANG ,  JOSEPH LITTLER BENJAMIN ,  ALI KESHAVARZ-SHOKRI ,  EDWARD ALCACIO TIM ,  BELMONT DANIEL T

IPC: A61K31/675 ,  A61P19/02 ,  C07F9/576

Abstract: The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.