公开(公告)号：HK1178892A1

公开(公告)日：2013-09-19

申请号：HK13105753

申请日：2013-05-16

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA S ,  HAMILTON MATTHEW M ,  MILLER MARK M ,  GROOTENHUIS PETER D J PDJ ,  BEAR BRIAN B ,  MCCARTHY JASON J ,  ZHOU JINGLAN

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..