公开(公告)号：AT440825T

公开(公告)日：2009-09-15

申请号：AT04754303

申请日：2004-06-04

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS ,  SINGH ASHVANI ,  MILLER MARK ,  HADIDA RUAH SARAH ,  GROOTENHUIS PETER ,  HAMILTON MATTHEW ,  HAZELWOOD ANNA ,  HUANG LIMING

IPC: C07D239/90 ,  C07D239/36 ,  C07D239/42 ,  C07D239/94 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10 ,  C07D513/04

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.