公开(公告)号：HK1150602A1

公开(公告)日：2012-01-06

申请号：HK11104646

申请日：2011-05-11

Applicant: VERTEX PHARMA

Inventor： SS S S HADIDA RUAH ,  AR A R HAZLEWOOD ,  PDJ P D J GROOTENHUIS ,  FF F F VAN GOOR ,  AK A K SINGH ,  ZHOU JINGLAN ,  J MCCARTNEY J

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  G01N20060101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.