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公开(公告)号：BR9610850A
公开(公告)日：1999-07-13
申请号：BR9610850
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating beta -hemoglobinopathies, including sickle cell syndromes and beta -thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：CA2283198A1
公开(公告)日：1998-09-17
申请号：CA2283198
申请日：1998-03-10
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN , SU MICHAEL SHIN-SAN
IPC: A61K31/00 , A61K31/215 , A61K31/22 , A61K48/00 , A61P1/00 , A61P7/00 , A61P7/06 , A61P17/14 , A61P35/00 , A61P43/00 , C07C69/66 , C07C69/68
Abstract: This invention relates to the use of butyrate prodrugs derived from lactic acid for treating inflammatory bowel disease. The invention also relates to the use of those prodrugs for the treatment of a chemotherapy-induced mucocutaneous side effect in a patient. The invention further relates to the use of butyrate prodrugs for treating lung, colo-rectal or prostate cancer. And the invention also relates to the use of butyrate prodrugs to treat cystic fibrosis and to enhance the efficiency of gene therapy.
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公开(公告)号：ZA9608388B
公开(公告)日：1997-05-13
申请号：ZA9608388
申请日：1996-10-04
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
CPC classification number: C07C69/68
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公开(公告)号：CA2233606A1
公开(公告)日：1997-04-10
申请号：CA2233606
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
IPC: A61K31/00 , A61K31/215 , A61K31/22 , A61P7/00 , A61P7/06 , A61P35/00 , C07C69/66 , C07C69/68 , C07C69/347
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating .beta.-hemoglobinopathies, including sickle cell syndromes and .beta.-thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：DK0969828T3
公开(公告)日：2002-12-30
申请号：DK98910204
申请日：1998-03-10
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN , SU MICHAEL SHIN-SAN
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Patent Agency Ranking
公开(公告)号：PT863866E
公开(公告)日：2001-09-28
申请号：PT96933967
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating beta -hemoglobinopathies, including sickle cell syndromes and beta -thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：DK0863866T3
公开(公告)日：2001-06-11
申请号：DK96933967
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： LI BIQIN , TUNG ROGER D
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating beta -hemoglobinopathies, including sickle cell syndromes and beta -thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：AT200893T
公开(公告)日：2001-05-15
申请号：AT96933967
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating beta -hemoglobinopathies, including sickle cell syndromes and beta -thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：AU718983B2
公开(公告)日：2000-05-04
申请号：AU7249896
申请日：1996-09-30
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN
Abstract: This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating beta -hemoglobinopathies, including sickle cell syndromes and beta -thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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公开(公告)号：PT969828E
公开(公告)日：2003-01-31
申请号：PT98910204
申请日：1998-03-10
Applicant: VERTEX PHARMA
Inventor： TUNG ROGER D , LI BIQIN , SU MICHAEL SHIN-SAN
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