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公开(公告)号：WO2008137619A2
公开(公告)日：2008-11-13
申请号：PCT/US2008062327
申请日：2008-05-02
Applicant: VERTEX PHARMA , STUDLEY JOHN , GOLEC JULIAN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , ROBINSON DANIEL
Inventor： STUDLEY JOHN , GOLEC JULIAN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , ROBINSON DANIEL
IPC: C07D417/14 , A61K31/4535
CPC classification number: C07D417/14 , C07D401/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2008128009A2
公开(公告)日：2008-10-23
申请号：PCT/US2008059975
申请日：2008-04-11
Applicant: VERTEX PHARMA , BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , JIMENEZ JUAN-MIGUEL
Inventor： BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , JIMENEZ JUAN-MIGUEL
IPC: C07D403/14 , A61K31/506 , A61P35/00
CPC classification number: C07D403/14 , C07D401/14 , C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及用作极光蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物以及使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2008137622A3
公开(公告)日：2009-03-05
申请号：PCT/US2008062330
申请日：2008-05-02
Applicant: VERTEX PHARMA , MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL
Inventor： MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL
IPC: C07D403/14 , A61K31/506 , A61P35/00 , C07D417/14
CPC classification number: C07D403/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2008115973A3
公开(公告)日：2008-12-04
申请号：PCT/US2008057465
申请日：2008-03-19
Applicant: VERTEX PHARMA , BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , O'DONNELL MICHAEL , BOYALL DEAN , PINDER JOANNE , EVERITT SIMON
Inventor： BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , O'DONNELL MICHAEL , BOYALL DEAN , PINDER JOANNE , EVERITT SIMON
IPC: C07D403/14 , A61K31/33 , A61K35/00 , C07D413/14 , C07D417/14 , C07D471/04
CPC classification number: C07D471/04 , C07D403/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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公开(公告)号：WO2008147626A2
公开(公告)日：2008-12-04
申请号：PCT/US2008062331
申请日：2008-05-02
Applicant: VERTEX PHARMA , MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL , DAVIS CHRISTOPHER , STUDLEY JOHN
Inventor： MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL , DAVIS CHRISTOPHER , STUDLEY JOHN
IPC: C07D401/14 , A61K31/4427 , C07D417/14
CPC classification number: C07D401/14 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及用作极光蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物以及使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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Patent Agency Ranking6.发明申请THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开作为蛋白激酶抑制剂的THIAZOLES，IMIDAZOLES和PYRAZOLES有用
公开(公告)号：WO2007117692A3
公开(公告)日：2008-01-10
申请号：PCT/US2007008819
申请日：2007-04-11
Applicant: VERTEX PHARMA , JIMENEZ JUAN-MIGUEL , KNEGTEL RONALD , ROBINSON DANIEL , COLLIER PHILIP
Inventor： JIMENEZ JUAN-MIGUEL , KNEGTEL RONALD , ROBINSON DANIEL , COLLIER PHILIP
IPC: C07D231/14 , A61K31/426 , A61P35/00 , C07D233/90 , C07D277/56
CPC classification number: C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：WO2008131103A3
公开(公告)日：2008-12-18
申请号：PCT/US2008060635
申请日：2008-04-17
Applicant: VERTEX PHARMA , BINCH HAYLEY , WESTCOTT JAMES , POLLARD JOHN , MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL
Inventor： BINCH HAYLEY , WESTCOTT JAMES , POLLARD JOHN , MORTIMORE MICHAEL , GOLEC JULIAN , ROBINSON DANIEL
IPC: C12Q1/48 , A61K31/00 , A61P35/00 , C07D403/12 , G06F19/16
CPC classification number: C07D403/12 , A61K31/506 , A61K45/06 , C07D401/14 , C12Q1/485 , G01N2500/04 , G06F19/16
Abstract: The present invention relates to drug discovery methods, particularly methods for assaying compounds for activity as Aurora kinase inhibitors. This invention also relates to a pharmacophore describing compounds that are able to promote a conformational change in the protein AuroraB and whose binding constant for the two-step process is given as Ki*. Finally, this invention also relates to compounds having the features of the pharmacophore.
Abstract translation: 本发明涉及药物发现方法，特别是用于测定化合物作为极光激酶抑制剂的活性的方法。 本发明还涉及描述能够促进蛋白质AuroraB中的构象变化的化合物的药效团，其两步法的结合常数以Ki *给出。 最后，本发明还涉及具有药效团特征的化合物。
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公开(公告)号：WO2007015923A8
公开(公告)日：2008-04-03
申请号：PCT/US2006028149
申请日：2006-07-21
Applicant: VERTEX PHARMA , BINCH HAYLEY , EVERITT SIMON , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
Inventor： BINCH HAYLEY , EVERITT SIMON , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
IPC: C07D403/04 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K31/551 , A61P35/00 , C07D401/14 , C07D403/14
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDKl protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora，FLT-3或PDK1蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2007056164A3
公开(公告)日：2007-12-13
申请号：PCT/US2006042994
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物以及使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2007056221A2
公开(公告)日：2007-05-18
申请号：PCT/US2006043096
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
IPC: A61K31/513
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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