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公开(公告)号：WO2010002956A3
公开(公告)日：2010-01-07
申请号：PCT/US2009/049346
申请日：2009-07-01
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , ZIMMERMANN, Nicole , GROOTENHUIS, Peter, D.J. , NUMA, Mehdi, Michel, Djamel , STAMOS, Dean , ANDERSON, Corey, Don , WHITNEY, Tara
Inventor： ZIMMERMANN, Nicole , GROOTENHUIS, Peter, D.J. , NUMA, Mehdi, Michel, Djamel , STAMOS, Dean , ANDERSON, Corey, Don , WHITNEY, Tara
IPC: C07D417/14 , A61K31/427 , A61P25/00 , A61P29/00
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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2.发明申请4(-3-(-2-(PHENYL)MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL)BENZENESULFONAMIDE DERIVATI VES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN 审中-公开4（-3 - （ - 2-（苯基）吗啉-4-基）-2-氧代吡咯烷-1-基）-N-（噻唑-2-基）苯并呋喃衍生物及相关化合物作为治疗疼痛的离子通道的调节剂
公开(公告)号：WO2009064747A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083165
申请日：2008-11-12
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi, Michel Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , KAWATKAR, Aarti, Sameer
Inventor： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi, Michel Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , KAWATKAR, Aarti, Sameer
IPC: C07D417/14 , A61K31/427 , A61P25/04
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007075895A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048802
申请日：2006-12-21
Applicant: VERTEX PHARMA , WILSON DEAN , FANNING LEV T D , SHETH URVI , MARTINBOROUGH ESTHER , TERMIN ANDREAS , NEUBERT TIMOTHY , ZIMMERMANN NICOLE , KNOLL TARA , WHITNEY TARA , KAWATKAR AARTI , LEHSTEN DANIELLE , STAMOS DEAN , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , GUTIERREZ COREY
Inventor： WILSON DEAN , FANNING LEV T D , SHETH URVI , MARTINBOROUGH ESTHER , TERMIN ANDREAS , NEUBERT TIMOTHY , ZIMMERMANN NICOLE , KNOLL TARA , WHITNEY TARA , KAWATKAR AARTI , LEHSTEN DANIELLE , STAMOS DEAN , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , GUTIERREZ COREY
CPC classification number: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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4.发明申请2-UREIDO-6-HETEROARYL-3H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE IV INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS 审中-公开2-UREIDO-6-HETEROARYL-3H-苯并咪唑-4-羧酸衍生物及相关化合物作为GYRASE和/或TOPOISOMERASE IV抑制剂治疗细菌感染
公开(公告)号：WO2003105846A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/018401
申请日：2003-06-11
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , CHARIFSON, Paul , DEININGER, David, D. , DRUMM, Joseph , GRILLOT, Anne-Laure , LIAO, Yusheng , OLIVER-SHAFFER, Patricia , STAMOS, Dean
Inventor： CHARIFSON, Paul , DEININGER, David, D. , DRUMM, Joseph , GRILLOT, Anne-Laure , LIAO, Yusheng , OLIVER-SHAFFER, Patricia , STAMOS, Dean
IPC: A61K31/4439
CPC classification number: C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07C275/06 , C07D401/14 , C07D403/04 , Y02A50/473 , Y02A50/478 , A61K2300/00
Abstract: The present invention relates to compounds of formula I, wherein X, Q, W, R 1 , R 2 and R 3 are as defined in the claims, which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in, mammals. The present invention also relates to a method for preparing these compounds.
Abstract translation: 本发明涉及式I化合物，其中X，Q，W，R 1，R 2和R 3如权利要求中所定义，其抑制细菌促旋酶和/或Topo IV和药学上可接受的 包含所述化合物的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。 本发明还涉及一种制备这些化合物的方法。
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5.发明申请4(-3-(-2-(PHENYL) MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL) BENZENESULFON AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN 审中-公开4（-3 - （ - 2-（苯基）吗啉基）-2-氧代吡咯烷-1-基）-N-（噻唑-2-基）苯甲酰胺衍生物和作为治疗疼痛的离子通道调节剂的相关化合物
公开(公告)号：WO2009064747A3
公开(公告)日：2010-08-19
申请号：PCT/US2008083165
申请日：2008-11-12
Applicant: VERTEX PHARMA , STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , KAWATKAR AARTI SAMEER
Inventor： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , KAWATKAR AARTI SAMEER
IPC: C07D417/14 , A61K31/427 , A61P25/04
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives of formula I useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, like, e.g. pain., (I) or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: ring Z is a thiazole or thiadiazole optionally substituted with 0-2 occurrences of R; V is CH2, NH, O, or S; and R, R1, R2, and R3 are hydrogen, C1-C6 aliphatic, aryl, C3-C8 cycloaliphatic, halo, CN, NO2, CF3, OCF3, OH, NH2, NH(C1-C6 aliphatic), N(C1-C6 aliphatic) 2, COOH, COO(C1 -C6 aliphatic), O(C1-C6 aliphatic), CHF2, or CH2F.
Abstract translation: 本发明涉及可用作离子通道抑制剂的式I的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法，例如， 疼痛，（I）或其药学上可接受的盐，其中独立地为每次出现：环Z是任选被0-2次出现的R取代的噻唑或噻二唑; V是CH 2，NH，O或S; R 1，R 2和R 3是氢，C 1 -C 6脂族基，芳基，C 3 -C 8脂环族基，卤素，CN，NO 2，CF 3，OCF 3，OH，NH 2，NH（C 1 -C 6脂族基） C 6脂族基）2，COOH，COO（C 1 -C 6脂族基），O（C 1 -C 6脂族基），CHF 2或CH 2 F。
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Patent Agency Ranking
公开(公告)号：WO2007015923A8
公开(公告)日：2008-04-03
申请号：PCT/US2006028149
申请日：2006-07-21
Applicant: VERTEX PHARMA , BINCH HAYLEY , EVERITT SIMON , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
Inventor： BINCH HAYLEY , EVERITT SIMON , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
IPC: C07D403/04 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K31/551 , A61P35/00 , C07D401/14 , C07D403/14
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDKl protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora，FLT-3或PDK1蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2008036272A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/020222
申请日：2007-09-18
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , ARONOV, Alexander , COME, Jon , COURT, John , DEININGER, David , LAUFFER, David , LI, Pan , MCGINTY, Kira , NANTHAKUMAR, Suganthini , STAMOS, Dean , TANNER, Kirk
Inventor： ARONOV, Alexander , COME, Jon , COURT, John , DEININGER, David , LAUFFER, David , LI, Pan , MCGINTY, Kira , NANTHAKUMAR, Suganthini , STAMOS, Dean , TANNER, Kirk
IPC: C07D497/04 , C07D513/04 , A61K31/433 , A61P35/00
CPC classification number: C07D497/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：WO2007075895A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/048802
申请日：2006-12-21
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , WILSON, Dean , FANNING, Lev, T.D. , SHETH, Urvi , MARTINBOROUGH, Esther , TERMIN, Andreas , NEUBERT, Timothy , ZIMMERMANN, Nicole , KNOLL, Tara , WHITNEY, Tara , KAWATKAR, Aarti , LEHSTEN, Danielle , STAMOS, Dean , ZHOU, Jinglan , ARUMUGAM, Vijayalaksmi , GUTIERREZ, Corey
Inventor： WILSON, Dean , FANNING, Lev, T.D. , SHETH, Urvi , MARTINBOROUGH, Esther , TERMIN, Andreas , NEUBERT, Timothy , ZIMMERMANN, Nicole , KNOLL, Tara , WHITNEY, Tara , KAWATKAR, Aarti , LEHSTEN, Danielle , STAMOS, Dean , ZHOU, Jinglan , ARUMUGAM, Vijayalaksmi , GUTIERREZ, Corey
IPC: C07D239/42 , C07D401/12 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/10 , A61K31/506 , A61P25/04
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：WO2006022773A1
公开(公告)日：2006-03-02
申请号：PCT/US2004/034919
申请日：2004-10-21
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , CHARIFSON, Paul, S. , DEININGER, David, D. , GRILLOT, Anne-Laure , LIAO, Yusheng , RONKIN, Steven, M. , STAMOS, Dean , PEROLA, Emanuele , WANG, Tiansheng , LE TIRAN, Arnaud , DRUMM, Joseph
Inventor： CHARIFSON, Paul, S. , DEININGER, David, D. , GRILLOT, Anne-Laure , LIAO, Yusheng , RONKIN, Steven, M. , STAMOS, Dean , PEROLA, Emanuele , WANG, Tiansheng , LE TIRAN, Arnaud , DRUMM, Joseph
IPC: C07D491/04
CPC classification number: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
Abstract translation: 本发明涉及抑制细菌回旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：WO2010002956A2
公开(公告)日：2010-01-07
申请号：PCT/US2009049346
申请日：2009-07-01
Applicant: VERTEX PHARMA , ZIMMERMANN NICOLE , GROOTENHUIS PETER D J , NUMA MEHDI MICHEL DJAMEL , STAMOS DEAN , ANDERSON COREY DON , WHITNEY TARA
Inventor： ZIMMERMANN NICOLE , GROOTENHUIS PETER D J , NUMA MEHDI MICHEL DJAMEL , STAMOS DEAN , ANDERSON COREY DON , WHITNEY TARA
IPC: C07D471/04 , A61K31/436 , A61P35/00
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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