公开(公告)号：AU2005260650A1

公开(公告)日：2006-01-12

申请号：AU2005260650

申请日：2005-06-30

Applicant: WISYS TECHNOLOGY FOUNDATION INC

Inventor： COOK JAMES M ,  HUANG SHENGMING ,  SARMA P V V S ,  ZHOU HAO ,  ZHANG CHUNCHUN

IPC: C07D243/16 ,  A61K31/5517 ,  A61P25/22 ,  C07D243/24 ,  C07D487/04 ,  C07D495/04 ,  C07D495/14

Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-IV, VI-XI, XV-XVIII and XX-XXI and a pharmaceutically-acceptable carrier.

公开(公告)号：AU2003230754B2

公开(公告)日：2007-10-25

申请号：AU2003230754

申请日：2003-03-28

Applicant: WISYS TECHNOLOGY FOUNDATION INC

Inventor： LII XIOAYAN ,  HUANG QI ,  COOK JAMES M ,  YU JIANMING ,  HAN DONGMEI ,  HE XIAOHUI

IPC: C07D243/12 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/5517 ,  A61P1/08 ,  A61P25/00 ,  A61P25/18 ,  A61P25/22 ,  C07D243/20 ,  C07D243/24 ,  C07D401/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.

公开(公告)号：AU2007221890A1

公开(公告)日：2007-10-25

申请号：AU2007221890

申请日：2007-10-09

Applicant: WISYS TECHNOLOGY FOUNDATION INC

Inventor： LELAS SNJEZANA ,  YU JIANMING ,  HUANG QI ,  HAN DONGMEI ,  LI XIOAYAN ,  COOK JAMES M ,  MCELROY JOHN F ,  HE XIAOHUI

IPC: C07D243/12 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/5517 ,  A61P1/08 ,  A61P25/00 ,  A61P25/18 ,  A61P25/22 ,  C07D243/20 ,  C07D243/24 ,  C07D401/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

公开(公告)号：AU2006276998A1

公开(公告)日：2007-02-15

申请号：AU2006276998

申请日：2006-05-16

Applicant: WISYS TECHNOLOGY FOUNDATION INC

Inventor： COOK JAMES M ,  HAN DONGMEI ,  CLAYTON TERRY

IPC: C07D497/04 ,  A61K31/5517 ,  A61P25/28 ,  C07D487/14

Abstract: The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.