公开(公告)号：WO2011112976A3

公开(公告)日：2011-09-15

申请号：PCT/US2011/028169

申请日：2011-03-11

Applicant: MAKRIDAKIS, Jennifer ,  PINS, George D. ,  PAGE, Raymond Lynn ,  DOMINKO, Tanja ,  MALCUIT, Christopher ,  Worcester Polytechnic Institute

Inventor： MAKRIDAKIS, Jennifer ,  PINS, George D. ,  PAGE, Raymond Lynn ,  DOMINKO, Tanja ,  MALCUIT, Christopher

IPC: A61F2/08 ,  A61L27/14 ,  A61L27/24 ,  A61L27/54 ,  A61L27/38

Abstract: An engineered muscle construct in the form of a braided collagen microthread scaffold is provided. The microthread scaffold can be used with or without cells as engineered skeletal muscle. The microthread scaffold can also be used to promote cell attachment and growth to deliver cells to a large muscle defect to stimulate muscle regeneration. Methods for making a muscle construct, seeding cells onto microthread scaffolds and treating muscle defects are also provided.

公开(公告)号：WO2016168653A1

公开(公告)日：2016-10-20

申请号：PCT/US2016/027832

申请日：2016-04-15

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： GAGNON, Keith A. ,  MOUTINHO, Thomas J. ,  REYER, Kevin A. ,  BORNSTEIN, Alyssa L. ,  O'BRIEN, Megan ,  PINS, George D. ,  GAUDETTE, Glenn R.

IPC: A61K48/00 ,  A61L9/04 ,  A61L27/38 ,  C12N5/00 ,  C12N5/071

CPC classification number: A61L27/225 ,  A61K35/34 ,  A61L27/3826 ,  A61L27/52 ,  A61L27/54 ,  B29C33/3842 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/405 ,  B29C33/424 ,  B29C41/003 ,  B29C41/20 ,  B29C41/42 ,  B29C65/002 ,  B29K2089/00 ,  B29K2883/00 ,  B29L2031/753 ,  C12N2533/56 ,  G03F7/0002 ,  G03F7/2002 ,  G03F7/32 ,  G03F7/38

Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.

Abstract translation: 支架，使用支架的方法和制备可促进细胞和组织的生长或存活的支架的方法。 所述支架包括由薄膜纤维蛋白形成的至少一个微血管层，所述微血管层被配置为维持和促进细胞的生长并且具有嵌入在所述微血管层中的一个或多个微流体通道，所述通道被配置成含有生长所需的营养物质 细胞和被配置为允许营养物从通道扩散到细胞的通道。

公开(公告)号：WO2008116189A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/057928

申请日：2008-03-21

Applicant: WORCESTER POLYTECHNIC INSTITUTE (WPI) ,  GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

Inventor： GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

IPC: A61B17/10

CPC classification number: A61L31/046 ,  A61B17/0469 ,  A61B17/06 ,  A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00893 ,  A61L27/225 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3873 ,  A61L31/16 ,  A61L2430/20 ,  C12N5/0068 ,  C12N11/02 ,  C12N2533/56

Abstract: Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium).

Abstract translation: 提供包括微丝的组合。 组合物可以沿其长度的至少一部分完全或部分地包封在套管中，并且可以包括生物细胞和任选的治疗剂。 还提供了使用组合物来修复或改善包括心血管组织（例如心肌）的损伤或缺陷组织的方法。