公开(公告)号：US20240299009A1

公开(公告)日：2024-09-12

申请号：US18667740

申请日：2024-05-17

Applicant: Worcester Polytechnic Institute

Inventor： Haichong Zhang ,  Shang Gao

IPC: A61B8/00 ,  A61B5/00 ,  A61B8/12 ,  A61B17/00 ,  A61B18/14 ,  A61B90/00

CPC classification number: A61B8/4461 ,  A61B5/0095 ,  A61B8/12 ,  A61B8/445 ,  A61B18/1492 ,  A61B2017/00106 ,  A61B2090/3782

Abstract: A photoacoustic (PA) sensor employs a linear deployment of an illumination source and a corresponding ultrasonic receiver for defining an imaging plane for rendering a PA image of a surgical or diagnostic region. A pair of illumination sources emanates from cladding removal of respective optical fibers, and irradiates in alignment with a side firing ultrasonic (US) array for receiving the induced PA signals. The US array extends longitudinally and parallel to the illumination sources, and an overlap of the respective irradiation regions extends from the illumination sources lies within a sensing region of the US array for defining an imaging plane captured by the US sensor for rendering on a visual device, often in conjunction with an ablation antenna or diagnostic probe for providing concurrent imaging during a surgical procedure.

公开(公告)号：US20230023217A1

公开(公告)日：2023-01-26

申请号：US17869130

申请日：2022-07-20

Applicant: Worcester Polytechnic Institute

Inventor： Haichong Zhang ,  Shang Gao

IPC: A61B5/00

Abstract: A photoacoustic imaging approach identifies, concurrently with ablation therapy, an extent of the ablation by measuring and rendering a necrotic extent of treated tissue in a treatment region. Laser pulsed light directed at the treatment region induces an acoustic (ultrasound) signal for differentiating ablated tissue from its non-ablative counterpart based on a photoacoustic spectrum variation. The acoustic signal indicates a range of necrotic extent based on a quantified ablated tissue contrast and a total contrast of both necrotic and non-necrotic tissue, defined as a fraction for computing a degree of necrosis. Generation of an image indicating the degree of necrosis allows continuous or near continuous feedback for ablation therapy guidance to ensure complete and effective ablation of the proper tissue in the treatment region.

公开(公告)号：US20240389861A1

公开(公告)日：2024-11-28

申请号：US18674020

申请日：2024-05-24

Applicant: Worcester Polytechnic Institute

Inventor： Haichong Zhang ,  Shang Gao ,  Xihan Ma

IPC: A61B5/00 ,  A61B34/10 ,  A61B34/20 ,  A61B34/30 ,  A61B90/00 ,  A61M25/01

Abstract: A photoacoustic (PA) sensor device has a localization feature that defines a position of the sensor or scan information with a coordinate frame defining relative positions a scanned specimen and sensor information of other imaging planes of the scanned specimen. The coordinate frame is defined by positional information from localization markers at a known offset from the sensor, or from position signals from a robotic actuator driving the sensor. A processor coalesces the sensor information and positional information to reconstruct a 3-dimensional rendered structure by stitching together the sensor information to form a continuous rendering. Stitching may include adjacent imaging planes at an angular offset due to a varied pose of the sensor, and/or adjacent images over a lateral area too large for a single scan or imaging plane to capture.