公开(公告)号：US10942120B2

公开(公告)日：2021-03-09

申请号：US16681805

申请日：2019-11-12

Applicant: Wyatt Technology Corporation

Inventor： Vincent Hsieh ,  Mario Yasa, Jr. ,  Steven C. Minne

IPC: G01N21/64 ,  G01N21/51 ,  G01N21/47

Abstract: An apparatus for the high throughput measurement of optical properties of liquid samples placed into the wells of a multiwell plate is disclosed. An optical fiber within a fiber bundle containing no corrective optics between the fiber ends and the well plate bottom illuminates the sample in order to induce fluorescence, and multiple fibers collect emission radiation and transmit it to a fluorescence detector such as a spectrometer. Other embodiments involve a light scattering illumination source with detection fibers located in either the same bundle containing the fluorescence monitoring fibers or an independent light scattering detection bundle for the measurement of static and/or dynamic light scattering. Some embodiments of the invention permit the measurement of phase analysis light scattering. Thus the measurement of multiple optical properties of a liquid sample may be made simultaneously or in succession. A method for these measurements is also disclosed.

公开(公告)号：US10473591B2

公开(公告)日：2019-11-12

申请号：US15583899

申请日：2017-05-01

Applicant: Wyatt Technology Corporation

Inventor： Vincent Hsieh ,  Mario Yasa, Jr. ,  Steven C Minne

IPC: G01N21/64 ,  G01N21/51 ,  G01N21/47

Abstract: An apparatus for the high throughput measurement of optical properties of liquid samples placed into the wells of a multiwell plate is disclosed. An optical fiber within a fiber bundle containing no corrective optics between the fiber ends and the well plate bottom illuminates the sample in order to induce fluorescence, and multiple fibers collect emission radiation and transmit it to a fluorescence detector such as a spectrometer. Other embodiments involve a light scattering illumination source with detection fibers located in either the same bundle containing the fluorescence monitoring fibers or an independent light scattering detection bundle for the measurement of static and/or dynamic light scattering. Some embodiments of the invention permit the measurement of phase analysis light scattering. Thus the measurement of multiple optical properties of a liquid sample may be made simultaneously or in succession. A method for these measurements is also disclosed.

公开(公告)号：US20180313758A1

公开(公告)日：2018-11-01

申请号：US15583899

申请日：2017-05-01

Applicant: Wyatt Technology Corporation

Inventor： Vincent Hsieh ,  Mario Yasa, Jr. ,  Steven C Minne

IPC: G01N21/64 ,  G01N21/51

CPC classification number: G01N21/6452 ,  G01N21/474 ,  G01N21/51 ,  G01N2021/4747 ,  G01N2021/475 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: An apparatus for the high throughput measurement of optical properties of liquid samples placed into the wells of a multiwell plate is disclosed. An optical fiber within a fiber bundle containing no corrective optics between the fiber ends and the well plate bottom illuminates the sample in order to induce fluorescence, and multiple fibers collect emission radiation and transmit it to a fluorescence detector such as a spectrometer. Other embodiments involve a light scattering illumination source with detection fibers located in either the same bundle containing the fluorescence monitoring fibers or an independent light scattering detection bundle for the measurement of static and/or dynamic light scattering. Some embodiments of the invention permit the measurement of phase analysis light scattering. Thus the measurement of multiple optical properties of a liquid sample may be made simultaneously or in succession. A method for these measurements is also disclosed.