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公开(公告)号：WO2019048930A2
公开(公告)日：2019-03-14
申请号：PCT/IB2018/001128
申请日：2018-09-07
Applicant: KEIO UNIVERSITY , BIOMX LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEITZMANN INSTITUTE OF SCIENCE
Inventor： HONDA, Kenya , ATARASHI, Koji , NARUSHIMA, Seiko , ELINAV, Eran , SOREK, Rotem , KHABRA, Efrat , BEN DAVID, Hava , WEINSTOCK, Eyal , POLLOCK, Sarah , MUTIUHIN, Yulia , ZAK, Naomi
IPC: A61K35/00
Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
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2.发明申请POLYNUCLEOTIDES ENCODING BREX SYSTEM POLYPEPTIDES AND METHODS OF USING S AME 审中-公开编码BREX系统聚合物的多核苷酸和使用SME的方法
公开(公告)号：WO2015059690A1
公开(公告)日：2015-04-30
申请号：PCT/IL2014/050902
申请日：2014-10-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , SBERRO, Hila , GOLDFARB, Tamara
IPC: C12N9/10 , C07K14/195
CPC classification number: C12N1/20 , A23C9/1234 , A23C2220/202 , C07K14/195 , C07K14/245 , C07K14/32 , C12N9/0051 , C12N9/1007 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/48 , C12N15/52 , C12Y108/04008 , C12Y201/01072 , C12Y207/11001 , C12Y301/03001 , C12Y304/00 , C12Y306/04012 , C12Y306/04013
Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHH, brxL, brxD, brxA, brxB, brxF , and brxE , with the proviso that said BREX system does not comprise pglW , and wherein said BREX system confers phage resistance to a bacteria recombinantiy expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI , and wherein said BREX system confers phage resistance to a bacteria recombinantiy expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
Abstract translation: 提供编码BREX系统的分离的多核苷酸。 因此，提供了编码BREX系统的分离的多核苷酸，其包含编码BREX系统的核酸序列，其包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHH，brxL，brxD，brxA，brxB，brxF中的至少一种 和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对表达其的重组细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统赋予对重组细菌的噬菌体抗性 表达相同。 还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。
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公开(公告)号：WO2019113066A1
公开(公告)日：2019-06-13
申请号：PCT/US2018/063842
申请日：2018-12-04
Applicant: BIOMX LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD. , WEINSTOCK, Eyal , BEN-DAVID, Hava , SUDAKOV, Kobi, Konstantin , MOSES, Ayelet , POLLOCK, Sarah, Rachel , SOREK, Rotem , ZAK, Naomi, Bluma
Inventor： WEINSTOCK, Eyal , BEN-DAVID, Hava , SUDAKOV, Kobi, Konstantin , MOSES, Ayelet , POLLOCK, Sarah, Rachel , SOREK, Rotem , ZAK, Naomi, Bluma
Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes ( P. acnes ) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.
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公开(公告)号：WO2018220616A3
公开(公告)日：2018-12-06
申请号：PCT/IL2018/050559
申请日：2018-05-23
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , OFIR, Gal , AMITAI, Gil , MELAMED, Sarah , DORON, Shany , LEAVITT, Azita
Abstract: Disclosed herein are microbial defense systems, which provide cells protection against phage infection and plasmid transformation. Methods of use of these defense systems for protecting cells from phage infection and plasmid transformation are also disclosed, wherein defense systems may be used individually or in combination. In addition, disclosed herein are methods of making cells that express these defense systems.
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5.发明申请
公开(公告)号：WO2018096547A1
公开(公告)日：2018-05-31
申请号：PCT/IL2017/051293
申请日：2017-11-28
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , AMITAI, Gil , ZOHAR, Erez
IPC: C12N15/63 , C07K14/435 , C12N15/85 , C12N15/67
Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an Aim R responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an Aim P peptide comprising an amino acid sequence of XXXXGG/A, wherein said Aim P peptide is capable of binding said Aim R polypeptide and dissociating said Aim R polypeptide from said Aim R responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.
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Patent Agency Ranking
公开(公告)号：WO2012164565A1
公开(公告)日：2012-12-06
申请号：PCT/IL2012/050194
申请日：2012-05-31
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SOREK, Rotem , AMITAI, Gil
Inventor： SOREK, Rotem , AMITAI, Gil
IPC: C12N15/113 , C12N15/11
CPC classification number: C07K14/195 , C12N15/113 , C12N2310/11 , C12N2310/3519 , C12N2310/531 , C12N2320/30
Abstract: An isolated polynucleotide is disclosed. The polynucleotide comprises a clustered, regularly interspaced short palindromic repeat (CRISPR) array nucleic acid sequence wherein at least one spacer of the CRISPR is sufficiently complementary to a portion of at least one prokaryotic gene so as to down-regulate expression of the prokaryotic gene and further comprises a nucleic acid sequence encoding at least one CRISPR associated (CAS) polypeptide of a repeat associated mysterious protein (RAMP) family. Uses of the polynucleotides and pharmaceutical compositions comprising the polynucleotides are also disclosed.
Abstract translation: 公开了一种分离的多核苷酸。 多核苷酸包含聚集的，规则间隔的短回文重复（CRISPR）阵列核酸序列，其中CRISPR的至少一个间隔基与至少一个原核基因的一部分充分互补，以便下调原核基因的表达， 还包含编码重复相关神经蛋白（RAMP）家族的至少一种CRISPR相关（CAS）多肽的核酸序列。 还公开了包含多核苷酸的多核苷酸和药物组合物的用途。
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公开(公告)号：WO2020202142A2
公开(公告)日：2020-10-08
申请号：PCT/IL2020/050377
申请日：2020-03-29
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , BERNHEIM, Aude , MILLMAN DAYAN, Adi Jenny
IPC: A61P31/12
Abstract: Disclosed herein are prokaryotic homologs of viperin (pVips), and nucleotide and nucleoside analogs produced from pVips. These nucleotide and nucleoside analogs stop nucleotide chain synthesis and provide host cells with resistance to viral infections by targeting actively replicating viral genome. Further, these nucleotide and nucleoside analogs decrease DNA replication in malignant cells. Further disclosed are methods of identifying pVips, and nucleotide and nucleoside analogs produced thereof.
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公开(公告)号：WO2019048930A3
公开(公告)日：2019-03-14
申请号：PCT/IB2018/001128
申请日：2018-09-07
Applicant: KEIO UNIVERSITY , BIOMX LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEITZMANN INSTITUTE OF SCIENCE
Inventor： HONDA, Kenya , ATARASHI, Koji , NARUSHIMA, Seiko , ELINAV, Eran , SOREK, Rotem , KHABRA, Efrat , BEN DAVID, Hava , WEINSTOCK, Eyal , POLLOCK, Sarah , MUTIUHIN, Yulia , ZAK, Naomi
Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
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公开(公告)号：WO2018220616A2
公开(公告)日：2018-12-06
申请号：PCT/IL2018/050559
申请日：2018-05-23
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , OFIR, Gal , AMITAI, Gil , MELAMED, Sarah , DORON, Shany , LEAVITT, Azita
Abstract: Disclosed herein are microbial defense systems, which provide cells protection against phage infection and plasmid transformation. Methods of use of these defense systems for protecting cells from phage infection and plasmid transformation are also disclosed, wherein defense systems may be used individually or in combination. In addition, disclosed herein are methods of making cells that express these defense systems.
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10.发明申请
公开(公告)号：WO2018096547A8
公开(公告)日：2018-05-31
申请号：PCT/IL2017/051293
申请日：2017-11-28
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： SOREK, Rotem , AMITAI, Gil , ZOHAR, Erez
IPC: C12N15/63 , C07K14/435 , C12N15/85 , C12N15/67
Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an AimR responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an AimP peptide comprising an amino acid sequence of XXXXGG/A, wherein said AimP peptide is capable of binding said AimR polypeptide and dissociating said AimR polypeptide from said AimR responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.
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