公开(公告)号：EP1780277A1

公开(公告)日：2007-05-02

申请号：EP06021361.8

申请日：1998-01-15

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Abramovich, Carolina ,  Chebat, Judith ,  Revel, Michel

IPC: C12N15/12

CPC classification number: C12N9/1007 ,  A61K38/21 ,  C07K14/4702 ,  A61K2300/00

Abstract: Novel proteins IR 1B1 and IR 1B4 have been isolated which bind to the type I IFN receptor IRNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the protein can be used for isolation of the new protein or for immunodetection thereof.

Abstract translation: 新的蛋白质IR 1B1和1B4 IR havebeen分离其结合到干扰素的细胞应答I型IFN受体IRNAR1类型和功能。 在有义或反义方向编码检查蛋白质的DNA可以施用以增强的任一个或抑制对干扰素的细胞响应。 抗体与蛋白可用于新的蛋白质的分离或用于其免疫检测。