公开(公告)号：EP0927252B1

公开(公告)日：2006-10-18

申请号：EP97919622.7

申请日：1997-04-29

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： NOVICK, Daniela ,  RUBINSTEIN, Menachem

IPC: C12N15/13 ,  C07K16/28 ,  A61K39/395 ,  C12N5/20 ,  G01N33/577 ,  G01N33/53

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K2317/76

Abstract: Antibodies directed against the ligand binding component of the interferon- alpha / beta receptor are provided, which are capable of selectively modulating the activity of various type-I interferons.

公开(公告)号：EP1222467A2

公开(公告)日：2002-07-17

申请号：EP00968194.1

申请日：2000-10-05

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： RUBINSTEIN, Menachem ,  COHEN, Batya

IPC: G01N33/68 ,  G01N33/74 ,  C12Q1/68 ,  C12N15/85

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74

Abstract: The invention provides a method for determining the presence of leptin, based on detecting leptin-induced angiopoietin-2 expression in some cells or cell lines, e.g. murine Swiss 3T3 F442A preadipocytes or human marrow stromal cell line hMS2-12. Leptin detection is e.g. performed transfecting cells with a vector comprising a reporter gene (e.g. Green Fluorescent Protein (GFP)) under the control of angiopoietin-2 promoter.

公开(公告)号：EP1222467B1

公开(公告)日：2006-03-29

申请号：EP00968194.1

申请日：2000-10-05

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： RUBINSTEIN, Menachem ,  COHEN, Batya

IPC: G01N33/68 ,  G01N33/74 ,  C12Q1/68 ,  C12N15/85

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74

Abstract: The invention provides a method for determining the presence of leptin in a sample.

公开(公告)号：EP0927252A1

公开(公告)日：1999-07-07

申请号：EP97919622.0

申请日：1997-04-29

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： NOVICK, Daniela ,  RUBINSTEIN, Menachem

IPC: C12N15 ,  A61P37 ,  A61P43 ,  C07K16 ,  C12N5 ,  C12P21 ,  G01N33 ,  A61K38

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K2317/76

Abstract: Antibodies directed against the ligand binding component of the interferon-α/β receptor are provided, which are capable of selectively modulating the activity of various type-I interferons.