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1.发明公开
公开(公告)号：EP2276460A2
公开(公告)日：2011-01-26
申请号：EP09726853.6
申请日：2009-03-26
Applicant: Yeda Research And Development Company Ltd.
Inventor： MIRELMAN, David , RABINKOV, Aharon
IPC: A61K9/00 , A61K9/70 , A61K36/8962 , A61K31/255
CPC classification number: A61K9/0036 , A61K9/0014 , A61K9/7084
Abstract: The present invention relates to a drug delivery device that is useful for topical treatment of various infections such as skin and nail, or vaginal infections. More specifically, the invention provides a device for topical administration of allicin to an infection site, comprising either one solid carrier or two adjacent solid carriers, dry alliin and dry alliinase, wherein either a mixture of said dry alliin and dry alliinase is contained within said one solid carrier or dry alliin and dry alliinase are each separately contained within each one of said two adjacent solid carriers, whereby in contact with the infection site and a wetting agent, the alliinase acts on the alliin and allicin is produced in situ and administered to the infection site
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公开(公告)号：EP0904361A1
公开(公告)日：1999-03-31
申请号：EP97915666.0
申请日：1997-04-14
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： MIRELMAN, David , WILCHEK, Meir , MIRON, Talia , RABINKOV, Aharon , SIVARAMAN, Hephzibah
Abstract: Immobilized garlic alliinase wherein the alliinase is chemically, physically or biologically immobilized, is useful in a method for continuous production of allicin. The method comprises adding a solution of alliin as substrate to a column containing said immobilized garlic alliinase and collecting pure allicin in the effluent. The pure allicin is intended for use as food additive or for the preparation of pharmaceutical compositions for the treatment of viral, bacterial, fungal and parasitic infections, high levels of cholesterol and blood lipids, high blood pressure and thrombosis.
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