公开(公告)号：EP2235178A2

公开(公告)日：2010-10-06

申请号：EP09704217.0

申请日：2009-01-25

Applicant: Yeda Research And Development Company Ltd.

Inventor： NEEMAN, Michal ,  COHEN, Batya ,  SAPOZNIK, Stav ,  BEN-DOR, Shifra ,  MEIR, Gila

IPC: C12N15/11 ,  A61K31/7088 ,  A61P35/00 ,  A61K38/18 ,  C07K14/475

CPC classification number: C07K14/475 ,  A61K31/7088 ,  A61K38/00 ,  C12N15/1136 ,  C12N2310/11

Abstract: The present invention relates to compounds and methods for inhibiting the expression of vascular endothelial growth factor-C (VEGF-C) in a target cell. Particularly, the present invention relates to antisense polynucleotides complementary to a lens epithelium-derived growth factor (LEDGF/p75) mRNA and uses thereof for inhibiting tumor progression and tumor metastasis. The present invention further relates to uses of LEDGF/p75 polypeptide or a nucleic acid encoding same for treating endothelial cell related conditions, particularly inflammation and edema.

Abstract translation: 本发明涉及抑制靶细胞中血管内皮生长因子-C（VEGF-C）表达的化合物和方法。 具体而言，本发明涉及与晶状体上皮衍生生长因子（LEDGF / p75）mRNA互补的反义多核苷酸及其用于抑制肿瘤进展和肿瘤转移的用途。 本发明还涉及LEDGF / p75多肽或其编码核酸的用途，用于治疗内皮细胞相关病症，特别是炎症和水肿。