公开(公告)号：US20170175127A1

公开(公告)日：2017-06-22

申请号：US15442784

申请日：2017-02-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef SHAUL ,  Peter TSVETKOV ,  Julia ADLER

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/1135 ,  C12N2310/14 ,  C12Q1/025 ,  C12Q1/68 ,  G01N33/5011 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10

Abstract: A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an agent which induces a dissociation of the 26S proteasomal complex into a 20S component and a 19S component to thereby inhibit 26S proteasomal activity, wherein the pharmaceutical agent is devoid of a chemotherapeutic agent.