公开(公告)号：US10040868B2

公开(公告)日：2018-08-07

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Moran Grossman ,  Nir Ben-Chetrit

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/40 ,  A61K45/06 ,  A61K33/24

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.