公开(公告)号：US20160051629A1

公开(公告)日：2016-02-25

申请号：US14781316

申请日：2014-04-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Anthony FUTERMAN ,  Einat VITNER ,  Ran SALOMON

IPC: A61K38/20

CPC classification number: A61K38/2006 ,  A61K45/06

Abstract: The present invention provides compositions and methods for treating lysosomal storage disease characterized by elevation of RIP kinase in a subject in need thereof using at least one RIP kinase inhibitor.

Abstract translation: 本发明提供用于治疗溶酶体贮积病的组合物和方法，其特征在于使用至少一种RIP激酶抑制剂在有需要的受试者中升高RIP激酶。

公开(公告)号：US20220403043A1

公开(公告)日：2022-12-22

申请号：US17870876

申请日：2022-07-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony DAHAN ,  Ran SALOMON

IPC: C07K16/28 ,  A61P35/00

Abstract: A multispecific antibody is provided. The antibody comprising a first moiety, which binds and activates CD40, a second moiety, which specifically binds a dendritic cell (DC) and a third moiety comprising a modified Fc region of the multispecific antibody for enhancing specificity and affinity of binding to FcγRIIb and uses of same.