公开(公告)号：US12291578B2

公开(公告)日：2025-05-06

申请号：US17429672

申请日：2020-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Vishnu Mohan

IPC: C07K16/40 ,  A61K31/282 ,  A61K31/7068 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30

Abstract: A method of treating a disease associated with imbalanced or abnormal activity of MMP-7 is diclosed. The method comprises administration of an antibody comprising an antigen recognition region which binds a catalytic site of MMP-7, having complementarity determining region amino acid sequences as set forth in: SEQ ID NOs: 3, 4 and 5 (CDR3), sequentially arranged from N to C on a light chain of the antibody; and SEQ ID NOs: 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody.