公开(公告)号：US07993586B2

公开(公告)日：2011-08-09

申请号：US11770080

申请日：2007-06-28

Applicant: Yoichi Fujiyama ,  Masakazu Akechi ,  Masaki Kanai

Inventor： Yoichi Fujiyama ,  Masakazu Akechi ,  Masaki Kanai

IPC: G01N21/00 ,  G01N31/12 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N27/07 ,  C02F1/32 ,  C02F1/42 ,  C02F2103/04 ,  C02F2209/05 ,  C02F2209/20 ,  G01N33/1846 ,  Y10T436/235

Abstract: Disclosed is a total organic carbon (TOC) measurement apparatus capable of facilitating reduction in size of the apparatus and achieving enhanced measurement accuracy. The TOC measurement apparatus includes an organics oxidation unit, a carbon-dioxide separation unit and a conductivity measurement unit, which are integrally formed by laminating a plurality of plates to define therebetween and incorporate therein an oxidizing flow passage, an aqueous-sample flow passage, a gas permeable membrane, a measurement-water flow passage and a conductivity measuring electrode. The TOC measurement apparatus is designed such that carbon oxide in an aqueous sample is transferred from the aqueous-sample flow passage to the measurement-water flow passage through the gas permeable membrane, and a conductivity of measurement water which contains the carbon oxide and flows through a flow passage facing the conductivity measuring electrode is determined and converted to a TOC content.

Abstract translation: 公开了一种总体有机碳（TOC）测量装置，其能够便于减小装置的尺寸并实现提高的测量精度。 TOC测量装置包括有机氧化单元，二氧化碳分离单元和电导率测量单元，它们通过层压多个板而形成在其间并在其中结合有氧化流动通道，水样品流动通道， 透气膜，测量 - 水流通道和电导率测量电极。 TOC测量装置被设计成使得水样品中的碳氧化物从水样品流动通道通过透气膜转移到测量水流动通道，并且包含含有碳氧化物并流过的测量水的电导率 确定面向导电性测量电极的流动通道并将其转换为TOC含量。

公开(公告)号：US20110003359A1

公开(公告)日：2011-01-06

申请号：US12865837

申请日：2009-02-03

Applicant: Yoichi Fujiyama ,  Yoichi Tagawa ,  Shunsuke Kobayashi

Inventor： Yoichi Fujiyama ,  Yoichi Tagawa ,  Shunsuke Kobayashi

IPC: C12N11/00

CPC classification number: C12M23/34 ,  A61M1/3689 ,  C12M25/02

Abstract: Disclosed is a biodevice which has a porous membrane (8) and flow paths (10) and (12) formed therein. In a preferred embodiment, the flow path (10) and the flow path (12) are opposed to each other with the porous membrane (8) being interposed between them. The flow path (10) serves as a first reaction chamber through which a first solution is allowed to pass so as to be brought into contact with one of the surfaces of the porous membrane (8). The flow path (12) serves as a second reaction chamber through which a second solution is allowed to pass so as to be brought into contact with the other surface of the porous membrane (8). In the flow path (10), first cells are immobilized on the porous membrane (8). In the flow path (12), second cells are immobilized on the porous membrane (8).

Abstract translation: 公开了一种生物装置，其具有形成在其中的多孔膜（8）和流路（10）和（12）。 在优选实施例中，流动路径（10）和流动路径（12）彼此相对，多孔膜（8）插入在它们之间。 流路（10）用作第一反应室，通过该第一反应室使第一溶液通过以与多孔膜（8）的一个表面接触。 流路（12）用作第二反应室，通过该第二反应室使第二溶液通过以与多孔膜（8）的另一表面接触。 在流路（10）中，将第一细胞固定在多孔膜（8）上。 在流路（12）中，将第二细胞固定在多孔膜（8）上。

公开(公告)号：US20120107947A1

公开(公告)日：2012-05-03

申请号：US13345032

申请日：2012-01-06

Applicant: Masakazu Akechi ,  Hirohisa Abe ,  Yoichi Fujiyama

Inventor： Masakazu Akechi ,  Hirohisa Abe ,  Yoichi Fujiyama

IPC: G01N27/00

CPC classification number: G01N33/1846 ,  G01N27/06

Abstract: A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part and carbon dioxide separation part and conductivity measuring part, control unit and data processing unit. In order to enhance the accuracy of conductivity measurement, the control unit is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part and carbon dioxide separation part. The data processing unit is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part.

Abstract translation: 一种总有机碳测量仪器，包括由有机物氧化部分和二氧化碳分离部分组成的测量单元和电导率测量部分，控制单元和数据处理单元。 为了提高电导率测量的准确性，控制单元构造成在有机物氧化时停止供给样品水，并在样品水移动到有机物时进行样品水的供给 物质氧化分解部分和二氧化碳分离部分。 数据处理单元被构造为基于在二氧化碳分离部分的相对强度为给定值或更高的紫外线照射的样品水到达时的电导率来测量总有机碳浓度。

公开(公告)号：US20100098588A1

公开(公告)日：2010-04-22

申请号：US12444563

申请日：2006-10-17

Applicant: Yoichi Fujiyama ,  Hirohisa Abe ,  Masakazu Akechi ,  Takeaki Inoue ,  Takeshi Iharada

Inventor： Yoichi Fujiyama ,  Hirohisa Abe ,  Masakazu Akechi ,  Takeaki Inoue ,  Takeshi Iharada

IPC: G01N27/06

CPC classification number: G01N33/1846 ,  G01N27/06 ,  Y10T436/23 ,  Y10T436/235

Abstract: [PROBLEMS] To use in a carbon dioxide separation part a gas-permeable membrane capable of maintaining high-speed determination and to diminish the influence of interfering ingredients.[MEANS FOR SOLVING PROBLEMS] An apparatus which comprises: an organic-substance oxidation part in which organic substances contained in a sample water supplied are oxidized into carbon dioxide; a carbon dioxide separation part in which the carbon dioxide contained in the sample water treated with the organic-substance oxidation part is caused to permeate and come into a measurement water; and a conductivity measurement part in which the conductivity of the measurement water sent from the carbon dioxide separation part is measured. The carbon dioxide separation part comprises: a sample water channel in which the sample water treated with the organic-substance oxidation part flows; an intermediate water part in which an intermediate water having a higher pH value in a neutral region than the sample water flowing through the sample water channel is present; and a measurement water channel through which the measurement water comprising deionized water flows. The sample water channel is in contact with the intermediate water part through a gas-permeable membrane, and the intermediate water part is in contact with the measurement water channel through a gas-permeable membrane.

Abstract translation: [问题]在二氧化碳分离部分中使用能够保持高速测定并减少干扰成分的影响的透气膜。 解决问题的手段一种装置，其特征在于，包括：有机物质氧化部，其中，供给的样品水中含有的有机物质被氧化成二氧化碳; 二氧化碳分离部，其中使含有有机物氧化部分处理的样品水中的二氧化碳渗透并进入测量水; 测定从二氧化碳分离部送出的测定水的电导率的电导率测定部。 二氧化碳分离部分包括：样品水通道，其中用有机物氧化部分处理的样品水流动; 中间水部分，其中存在在中性区域中具有比流过样品水通道的样品水更高的pH值的中间水; 以及包含去离子水的测量水流过的测量水通道。 样品水通道通过透气膜与中间水部分接触，中间水部分通过气体渗透膜与测量水通道接触。

公开(公告)号：US20080085216A1

公开(公告)日：2008-04-10

申请号：US11794728

申请日：2005-12-28

Applicant: Masakazu Akechi ,  Yoichi Fujiyama ,  Hirohisa Abe ,  Masaki Kanai

Inventor： Masakazu Akechi ,  Yoichi Fujiyama ,  Hirohisa Abe ,  Masaki Kanai

IPC: B01D53/22 ,  G01N30/00

CPC classification number: B01D19/00 ,  B01D19/0021 ,  B01D67/0032 ,  B01D71/50 ,  B01D2323/04 ,  B01D2323/28 ,  B01J2219/00905 ,  G01N1/4005 ,  G01N33/1846 ,  G01N2001/4016 ,  Y10T436/2575

Abstract: A gas exchange chip comprises substrates (1,2); two flow channels (3,4) formed in the substrates (1,2) and each having an inlet port and an outlet port; and multiple grooves (9) interlinking the flow channels (3,4). The grooves (9) have the size of their sectional area predetermined and have at least a part of the internal surface thereof rendered hydrophobic so as to permit the transfer of gas component while inhibiting any liquid passage. A sample water containing carbon dioxide is caused to flow through one of the flow channels (3) while pure water is caused to flow through the other flow channel (4) to thereby transfer the carbon dioxide contained in the sample water into the pure water.

Abstract translation: 气体交换芯片包括基板（1,2）; 形成在基板（1,2）中并且各自具有入口和出口的两个流动通道（3,4） 以及多个沟槽（9），其连接流动通道（3,4）。 凹槽（9）具有预定的截面面积的尺寸，并且其内表面的至少一部分变得疏水，从而允许气体成分的转移，同时抑制任何液体通道。 使含有二氧化碳的样品水流过其中一个流动通道（3），同时使纯水流过另一个流动通道（4），从而将样品水中所含的二氧化碳转移到纯水中。

公开(公告)号：US06559940B2

公开(公告)日：2003-05-06

申请号：US09748170

申请日：2000-12-27

Applicant: Yoichi Fujiyama

Inventor： Yoichi Fujiyama

IPC: G01N110

CPC classification number: G01N21/05 ,  G01N2021/0346 ,  G01N2201/064

Abstract: A measuring cell is formed of base plates joined together. A passage groove is formed on a joining surface of one base plate. Through-holes for introducing and discharging a fluid sample are formed on the other base plate, and the joining surface is provided with an optically opaque Si film as slits. Further, the joining surfaces of the base plates and the inner surface of the passage groove are covered with SiO2 films. Thus, a measuring cell having a sufficiently small passage sectional area, a high air-tightness, a chemically stable measuring chamber, and a high measuring sensitivity can be obtained.

Abstract translation: 测量单元由连接在一起的基板形成。 在一个基板的接合面上形成通道槽。 在另一个基板上形成用于引入和排出流体样品的通孔，并且接合表面设置有不透光的Si膜作为狭缝。 此外，基板的接合面和通道槽的内表面被SiO 2膜覆盖。 因此，可以获得具有足够小的通道截面积，高气密性，化学稳定的测量室和高测量灵敏度的测量池。

公开(公告)号：US08361414B2

公开(公告)日：2013-01-29

申请号：US11794728

申请日：2005-12-28

Applicant: Masakazu Akechi ,  Yoichi Fujiyama ,  Hirohisa Abe ,  Masaki Kanai

Inventor： Masakazu Akechi ,  Yoichi Fujiyama ,  Hirohisa Abe ,  Masaki Kanai

IPC: B01L3/00 ,  G01N1/10

CPC classification number: B01D19/00 ,  B01D19/0021 ,  B01D67/0032 ,  B01D71/50 ,  B01D2323/04 ,  B01D2323/28 ,  B01J2219/00905 ,  G01N1/4005 ,  G01N33/1846 ,  G01N2001/4016 ,  Y10T436/2575

Abstract: [PROBLEMS] To increase the rate of gas transfer in gas exchangers.[MEANS FOR SOLVING PROBLEMS] A gas exchange chip comprises substrates (1,2); two flow channels (3,4) formed in the substrates (1,2) and each having an inlet port and an outlet port; and multiple grooves (9) interlinking the flow channels (3,4). The grooves (9) have the size of their sectional area predetermined and have at least a part of the internal surface thereof rendered hydrophobic so as to permit the transfer of gas component while inhibiting any liquid passage. A sample water containing carbon dioxide is caused to flow through one of the flow channels (3) while pure water is caused to flow through the other flow channel (4) to thereby transfer the carbon dioxide contained in the sample water into the pure water.

Abstract translation: [问题]提高气体交换器中的气体传输速率。 解决问题的手段气体交换芯片包括基板（1,2）; 形成在基板（1,2）中并且各自具有入口和出口的两个流动通道（3,4） 以及多个沟槽（9），其连接流动通道（3,4）。 凹槽（9）具有预定的截面面积的尺寸，并且其内表面的至少一部分变得疏水，从而允许气体成分的转移，同时抑制任何液体通道。 使含有二氧化碳的样品水流过其中一个流动通道（3），同时使纯水流过另一个流动通道（4），从而将样品水中所含的二氧化碳转移到纯水中。

公开(公告)号：US20080220533A1

公开(公告)日：2008-09-11

申请号：US11915376

申请日：2005-11-29

Applicant: Yoichi Fujiyama ,  Yozo Morita ,  Isao Katasho

Inventor： Yoichi Fujiyama ,  Yozo Morita ,  Isao Katasho

IPC: G01N27/00

CPC classification number: G01N33/1846 ,  G01N27/06 ,  G01N31/005 ,  Y10T436/176152 ,  Y10T436/235

Abstract: Disclosed herein is a method for measuring total organic carbon without the influence of nitrogen components. The method for measuring total organic carbon includes the steps of: (1) adjusting the hydrogen ion concentration of sample water to between pH 4 and pH 6; (2) decomposing organic matter and nitrogen compounds contained in the sample water into carbon dioxide and nitrous acid, respectively, through oxidation and; (3) making the carbon dioxide permeate into measuring water via a gas-permeable part 5a; (4) and measuring the electric conductivity of the measuring water to determine the total organic carbon content of the sample water.

Abstract translation: 本文公开了一种不受氮成分影响的总有机碳的测定方法。 测定总有机碳的方法包括以下步骤：（1）将样品水的氢离子浓度调节至pH4至pH6之间; （2）通过氧化将样品水中含有的有机物和氮化合物分解成二氧化碳和亚硝酸; （3）通过透气部分5a使二氧化碳渗透到测量水中; （4）并测量测量水的电导率，以确定样品水的总有机碳含量。

公开(公告)号：US08557597B2

公开(公告)日：2013-10-15

申请号：US13345032

申请日：2012-01-06

Applicant: Masakazu Akechi ,  Hirohisa Abe ,  Yoichi Fujiyama

Inventor： Masakazu Akechi ,  Hirohisa Abe ,  Yoichi Fujiyama

IPC: G01N33/00 ,  G01N25/08 ,  G01N1/10 ,  G01N31/12

CPC classification number: G01N33/1846 ,  G01N27/06

Abstract: A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part and carbon dioxide separation part and conductivity measuring part, control unit and data processing unit. In order to enhance the accuracy of conductivity measurement, the control unit is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part and carbon dioxide separation part. The data processing unit is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part.

Abstract translation: 一种总有机碳测量仪器，包括由有机物氧化部分和二氧化碳分离部分组成的测量单元和电导率测量部分，控制单元和数据处理单元。 为了提高电导率测量的准确性，控制单元构造成在有机物氧化时停止供给样品水，并在样品水移动到有机物时进行样品水的供给 物质氧化分解部分和二氧化碳分离部分。 数据处理单元被构造为基于在二氧化碳分离部分的相对强度为给定值或更高的紫外线照射的样品水到达时的电导率来测量总有机碳浓度。

公开(公告)号：US07931865B2

公开(公告)日：2011-04-26

申请号：US12444563

申请日：2006-10-17

Applicant: Yoichi Fujiyama ,  Hirohisa Abe ,  Masakazu Akechi ,  Takeaki Inoue ,  Takeshi Iharada

Inventor： Yoichi Fujiyama ,  Hirohisa Abe ,  Masakazu Akechi ,  Takeaki Inoue ,  Takeshi Iharada

IPC: G01N31/12 ,  G01N21/00 ,  G01N31/00 ,  G01N33/00 ,  G01N27/00 ,  G01N15/06 ,  G01N33/48

CPC classification number: G01N33/1846 ,  G01N27/06 ,  Y10T436/23 ,  Y10T436/235

Abstract: An apparatus which comprises: an organic-substance oxidation part in which organic substances contained in a sample water supplied are oxidized into carbon dioxide; a carbon dioxide separation part in which the carbon dioxide contained in the sample water is caused to permeate and come into a measurement water; and a conductivity measurement part in which the conductivity of the measurement water is measured. The carbon dioxide separation part comprises: a sample water channel in which sample water flows; an intermediate water part in which intermediate water having a higher pH value in a neutral region than the sample water is present; and a measurement water channel through which the measurement water comprising deionized water flows. The sample water channel is in contact with the intermediate water part through a gas-permeable membrane, and the intermediate water part is in contact with the measurement water channel through a gas-permeable membrane.

Abstract translation: 一种装置，包括：有机物质氧化部分，其中包含在供应的样品水中的有机物质被氧化成二氧化碳; 二氧化碳分离部，其中包含在样品水中的二氧化碳渗透并进入测量水; 测定测定水的电导率的电导率测定部。 二氧化碳分离部分包括：样品水流过的样品水通道; 中间水部分，其中存在在中性区域中具有比样品水更高的pH值的中间水; 以及包含去离子水的测量水流过的测量水通道。 样品水通道通过透气膜与中间水部分接触，中间水部分通过气体渗透膜与测量水通道接触。