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公开(公告)号：JP2004041726A
公开(公告)日：2004-02-12
申请号：JP2003173769
申请日：2003-06-18
Applicant: Zimmer Inc , ジンマー,インコーポレイティド
Inventor： MEDLIN DANA , CHARLESBOIS STEVEN J , CLARKE WILLIAM B , PLETCHER DIRK , SCRAFTON JOEL , SHETTY H RAVINDRANATH , SWARTS DALE
IPC: A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/34 , A61F2/38 , A61L27/04 , A61L27/30 , A61L27/56 , B22F7/00 , B22F7/06 , B22F7/08 , C23C26/00
CPC classification number: C23C26/00 , A61F2/30767 , A61F2/30907 , A61F2/3094 , A61F2/3859 , A61F2002/30787 , A61F2002/30967 , A61F2002/30968 , A61F2002/30978 , A61F2002/3401 , A61F2310/00023 , A61F2310/00029 , A61F2310/00407 , A61F2310/00544 , A61L27/04 , A61L27/30 , A61L27/56 , B22F7/004 , B22F7/064
Abstract: PROBLEM TO BE SOLVED: To provide a method for attaching a porous metal layer to a dense metal substrate, particularly useful in providing orthopedic implants such as femoral knee components or acetabular cups. SOLUTION: This method, in one embodiment thereof, comprises a process 120 for providing a structured porous layer; a process 110 for providing the dense metal substrate; a process 130 for providing a binding mixture; a process 140 for applying the binding mixture to the exterior of the substrate; a process 150 for placing the porous layer against the substrate such that the binding mixture is disposed there while forming an assembly; and a process 160 for heat-treating the assembly to metallurgically bond the porous layer to the substrate. COPYRIGHT: (C)2004,JPO
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公开(公告)号：WO2016153925A8
公开(公告)日：2016-10-27
申请号：PCT/US2016022896
申请日：2016-03-17
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK
IPC: C08J7/06 , A61L27/16 , A61L27/50 , B29C71/02 , C08J3/20 , C08J3/28 , C08J7/12 , C08K5/00 , C08K5/1545 , C08L23/04
CPC classification number: C08J3/203 , A61L27/16 , A61L27/505 , A61L2430/02 , B05D3/068 , B29C71/02 , B29C71/04 , B29C2035/0877 , B29K2023/0683 , C08J3/24 , C08J3/28 , C08J7/065 , C08J7/08 , C08J7/123 , C08J2323/04 , C08J2323/06 , C08K5/005 , C08K5/1545 , C08K5/529 , C08K2201/013 , C08L23/06
Abstract: Various embodiments disclosed relate to melt-stabilized ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants made from the same. In various embodiments, the present invention provides a method of melt- stabilizing UHMWPE. The method can include coating a solid material including UHMWPE with an antioxidant, to provide an antioxidant-coated solid material. The method can include pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method can include irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method can include post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method can also include solidifying the heated material, to provide a melt-stabilized material.
Abstract translation: 公开的各种实施方式涉及熔体稳定的超高分子量聚乙烯（UHMWPE），其制造方法以及由其制成的医用植入物。 在各种实施方案中，本发明提供了一种使UHMWPE熔体稳定的方法。 该方法可以包括用抗氧化剂涂覆包括UHMWPE的固体材料，以提供抗氧化剂涂覆的固体材料。 该方法可以包括预辐射加热抗氧化剂涂覆的固体材料以扩散其中的抗氧化剂，以提供抗氧化剂扩散的固体材料。 该方法可以包括照射抗氧化剂扩散的固体材料，以提供照射的固体材料。 该方法可以包括辐射后加热照射的固体材料，该加热足以熔化UHMWPE的至少一部分，以提供加热的材料。 该方法还可以包括固化加热的材料，以提供熔融稳定的材料。
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3.发明申请AN ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 审中-公开用于医疗器械应用的抗氧化稳定交联超高分子量聚乙烯
公开(公告)号：WO2008124825A2
公开(公告)日：2008-10-16
申请号：PCT/US2008059909
申请日：2008-04-10
Applicant: ZIMMER INC , PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
Inventor： PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
CPC classification number: C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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4.发明申请
公开(公告)号：WO2010011412A3
公开(公告)日：2010-04-15
申请号：PCT/US2009045286
申请日：2009-05-27
Applicant: ZIMMER INC , YAKIMICKI DONALD , THOMAS BRIAN H , RUFNER ALICIA , PLETCHER DIRK , BRINKERHUFF HALLIE E , HAWKINS MICHAEL E
Inventor： YAKIMICKI DONALD , THOMAS BRIAN H , RUFNER ALICIA , PLETCHER DIRK , BRINKERHUFF HALLIE E , HAWKINS MICHAEL E
CPC classification number: B29C71/04 , A61L27/16 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29C2791/005 , B29K2023/0683 , B29L2031/7532 , C08J3/247 , C08J3/28 , C08J7/08 , C08J2323/06 , C08L23/06
Abstract: UHMWPE is exposed to crosslinking radiation and than heated utilizing infrared radiation in an inert environment. In one exemplary embodiment, the infrared radiation is provided by an infrared heater having a tungsten heating element with a quartz tube. In this embodiment, the infrared radiation may have the wavelength from about 1.0 micron to about 1.5 microns. In another exemplary embodiment, the UHMWPE is compression molded into bars prior to exposure to the crosslinking radiation.
Abstract translation: UHMWPE暴露于交联辐射，并且在惰性环境中使用红外辐射加热。 在一个示例性实施例中，红外辐射由具有带有石英管的钨加热元件的红外加热器提供。 在该实施例中，红外辐射可以具有约1.0微米至约1.5微米的波长。 在另一示例性实施例中，UHMWPE在暴露于交联辐射之前被压缩成型。
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公开(公告)号：AU2014274546B2
公开(公告)日：2016-06-02
申请号：AU2014274546
申请日：2014-12-10
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
Abstract: The present invention provides a method for processing a blend comprising UHMWPE for use in medical applications. The method comprising processing a blend comprising UHMWPE and 0.01 to 3.0 weight percent of an antioxidant to consolidate the blend, the consolidated blend having a melting point. Preheating the consolidated blend to a preheat temperature above room temperature and below the melting point of the consolidated blend. Irradiating the consolidated blend while maintaining the consolidated blend at a temperature below the melting point of the consolidated blend. The present invention also provides a crosslinked UHMWPE blend for use in medical implants prepared by a process comprising the steps of processing a blend comprising UHMWPE and 0.01 to 3.0 weight percent of an antioxidant to consolidate the blend, the consolidated blend having a melting point. Preheating the consolidated blend to a preheat temperature above room temperature and below the melting point of the consolidated blend, irradiating the consolidated blend with a total irradiation dose of at least 100 kGy while maintaining the consolidated blend at a temperature below the melting point of the consolidated blend.
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Patent Agency Ranking
公开(公告)号：CA2678459C
公开(公告)日：2016-05-24
申请号：CA2678459
申请日：2008-04-10
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
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公开(公告)号：AU2015358476B2
公开(公告)日：2019-08-15
申请号：AU2015358476
申请日：2015-12-03
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK
Abstract: Various embodiments disclosed relate to antioxidant-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of adding antioxidant to UHMWPE. The method includes obtaining or providing a porous solid material including UHMWPE. The method includes coating the porous solid material with a liquid composition including at least one antioxidant such that at least some of the liquid composition enters void space of the porous solid material, to provide an antioxidant-infused solid material. The method also includes melt-consolidating the antioxidant-infused solid material, to provide a melt-consolidated material.
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公开(公告)号：AU2014274546A1
公开(公告)日：2015-01-22
申请号：AU2014274546
申请日：2014-12-10
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
Abstract: The present invention provides a method for processing a blend comprising UHMWPE for use in medical applications. The method comprising processing a blend comprising UHMWPE and 0.01 to 3.0 weight percent of an antioxidant to consolidate the blend, the consolidated blend having a melting point. Preheating the consolidated blend to a preheat temperature above room temperature and below the melting point of the consolidated blend. Irradiating the consolidated blend while maintaining the consolidated blend at a temperature below the melting point of the consolidated blend. The present invention also provides a crosslinked UHMWPE blend for use in medical implants prepared by a process comprising the steps of processing a blend comprising UHMWPE and 0.01 to 3.0 weight percent of an antioxidant to consolidate the blend, the consolidated blend having a melting point. Preheating the consolidated blend to a preheat temperature above room temperature and below the melting point of the consolidated blend, irradiating the consolidated blend with a total irradiation dose of at least 100 kGy while maintaining the consolidated blend at a temperature below the melting point of the consolidated blend.
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公开(公告)号：AU2013200780A1
公开(公告)日：2013-02-28
申请号：AU2013200780
申请日：2013-02-08
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK , BRINKERHUFF HALLIE E , SCHNEIDER WERNER , GSELL RAY , ROWE TONI , RUFNER ALICIA , KNIGHT JOHN
Abstract: An antioxidant stabilized, consolidated, irradiation-crosslinked homogeneous blend comprising ultra-high molecular weight polyethylene powder and an antioxidant, the 5 crosslinked blend for use in medical applications, the consolidated blend being preheated to a temperature below the melting point of the consolidated blend prior to the crosslinking irradiation, the temperature of the consolidated blend being maintained below the melting point of the consolidated blend during the crosslinking irradiation, a portion of the antioxidant remaining in the polyethylene blend after the crosslinking irradiation, and the polyethylene 10 blend having an oxidation index of less than 0.10.
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公开(公告)号：CA2969751C
公开(公告)日：2020-09-22
申请号：CA2969751
申请日：2015-12-03
Applicant: ZIMMER INC
Inventor： PLETCHER DIRK
Abstract: Various embodiments disclosed relate to antioxidant-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of adding antioxidant to UHMWPE. The method includes obtaining or providing a porous solid material including UHMWPE. The method includes coating the porous solid material with a liquid composition including at least one antioxidant such that at least some of the liquid composition enters void space of the porous solid material, to provide an antioxidant-infused solid material. The method also includes melt-consolidating the antioxidant-infused solid material, to provide a melt-consolidated material.
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