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公开(公告)号：AU2016204932A1
公开(公告)日：2016-07-28
申请号：AU2016204932
申请日：2016-07-14
Applicant: ZOLL CIRCULATION INC
Inventor： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: H:\td\lnterwoven\NRPortbl\DCC\TLD\10494939 _docx-14/07/2016 -68 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region 5 for neuroprotection. The temperature modification is accomplished using an in dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a 10 heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may 15 include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
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公开(公告)号：AU2011201173C1
公开(公告)日：2013-10-03
申请号：AU2011201173
申请日：2011-03-16
Applicant: ZOLL CIRCULATION INC
Inventor： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv
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公开(公告)号：AU2011201173A1
公开(公告)日：2011-04-07
申请号：AU2011201173
申请日：2011-03-16
Applicant: ZOLL CIRCULATION INC
Inventor： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
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公开(公告)号：AU2005222530B9
公开(公告)日：2009-07-23
申请号：AU2005222530
申请日：2005-10-12
Applicant: ZOLL CIRCULATION INC
Inventor： MACHOLD TIMOTHY R , KELLER WADE A , DAE MICHAEL W
IPC: A61B17/00 , A61F7/00 , A61F7/02 , A61F7/12 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/439 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/472 , A61K31/485 , A61K31/496 , A61K31/506 , A61K31/553 , A61K45/00 , A61K45/06 , A61M25/00 , A61P25/00 , A61P25/04 , A61P29/00 , A61P41/00 , A61P43/00
Abstract: A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an alpha2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various alpha2-adrenoreceptor agonistalpha2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the alpha2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.
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公开(公告)号：AU2005222530B2
公开(公告)日：2009-06-04
申请号：AU2005222530
申请日：2005-10-12
Applicant: ZOLL CIRCULATION INC
Inventor： MACHOLD TIMOTHY R , KELLER WADE A , DAE MICHAEL W
IPC: A61B17/00 , A61F7/00 , A61F7/02 , A61F7/12 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/439 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/472 , A61K31/485 , A61K31/496 , A61K31/506 , A61K31/553 , A61K45/00 , A61K45/06 , A61M25/00 , A61P25/00 , A61P25/04 , A61P29/00 , A61P41/00 , A61P43/00
Abstract: A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an alpha2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various alpha2-adrenoreceptor agonistalpha2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the alpha2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.
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Patent Agency Ranking
公开(公告)号：AU2013222017B2
公开(公告)日：2016-04-14
申请号：AU2013222017
申请日：2013-08-30
Applicant: ZOLL CIRCULATION INC
Inventor： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: H:\tld\Intrwovn\NRPortbl\DCC\TLD\5431482_I.doc-30/08/2013 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature. WO 02/07793 PCT/USOI/23009 co - - - - - - - - - - - - - z U) ri -------------- ---- ------- 5 _j -:L. > "2D- 0 m y C) CL lil M 0 ------------------ 0 IL C) Ir C) cc cc) a--L Z) (No) ro) w a- V- CL 1 0 0 T 1 0-::) CL C) - ------- --- ----w :z) U) W w m D U)
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公开(公告)号：AU2011201173B2
公开(公告)日：2013-05-30
申请号：AU2011201173
申请日：2011-03-16
Applicant: ZOLL CIRCULATION INC
Inventor： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv
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公开(公告)号：AU2007201161B2
公开(公告)日：2010-12-16
申请号：AU2007201161
申请日：2007-03-16
Applicant: ZOLL CIRCULATION INC
Inventor： MACHOLD TIMOTHY R , ROTH ALEX T , KELLER WADE A , BLOOM NICOLE DENISE
Abstract: C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv
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公开(公告)号：AU2016204932B2
公开(公告)日：2019-04-04
申请号：AU2016204932
申请日：2016-07-14
Applicant: ZOLL CIRCULATION INC
Inventor： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: H:\tId\lnterwoven\NRPortbl\DCCTLD\10494939 _docx-14/07/2016 -68 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region 5 for neuroprotection. The temperature modification is accomplished using an in dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a 10 heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may 15 include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
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公开(公告)号：AU2013222017A1
公开(公告)日：2013-09-19
申请号：AU2013222017
申请日：2013-08-30
Applicant: ZOLL CIRCULATION INC
Inventor： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
Abstract: H:\tld\Intrwovn\NRPortbl\DCC\TLD\5431482_I.doc-30/08/2013 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature. WO 02/07793 PCT/USOI/23009 co - - - - - - - - - - - - - z U) ri -------------- ---- ------- 5 _j -:L. > CL 0 IL C) Ir C) cc cc) a--L Z) (No) ro) w a- V- CL 1 0 0 T 1 0-::) CL C) - ------- --- ----w :z) U) W w m D U)
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