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    Selection Method and Recombinant Microorganisms and uses Therefor
    8.
    发明申请
    Selection Method and Recombinant Microorganisms and uses Therefor 审中-公开
    选择方法和重组微生物及其用途

    公开(公告)号：US20130316364A1

    公开(公告)日：2013-11-28

    申请号：US13900172

    申请日：2013-05-22

    Applicant: LanzaTech New Zealand Limited

    Inventor： Michael Koepke ,  Bakir Al-Sinawi

    IPC: C12N15/74

    CPC classification number: C12N15/65 ,  C12N1/20 ,  C12N9/1014 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12N15/74 ,  C12Y201/02011 ,  C12Y202/01011 ,  C12Y401/01011 ,  C12Y401/99017 ,  C12Y603/02001

    Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.

    Abstract translation: 用于维生素或其它必需营养物质的生物合成途径中的一个或多个基因可用作微生物存活所需的有效选择性标记，以鉴定用外源核酸转化的细胞。 微生物不天然含有或表达一个或多个基因。 这允许执行遗传操作。 它允许执行较低成本的发酵。 它允许生产用于随后商品使用的必需营养物质。

    Microorganisms and processes for enhanced production of pantothenate
    9.
    发明授权
    Microorganisms and processes for enhanced production of pantothenate 有权
    用于增加泛酸盐生产的微生物和方法

    公开(公告)号：US07244593B2

    公开(公告)日：2007-07-17

    申请号：US10466641

    申请日：2002-01-18

    Applicant: R. Roger Yocum ,  Thomas A. Patterson ,  Janice G. Pero ,  Theron Hermann

    Inventor： R. Roger Yocum ,  Thomas A. Patterson ,  Janice G. Pero ,  Theron Hermann

    IPC: C12P13/04

    CPC classification number: C12N9/0006 ,  C12N9/1014 ,  C12N9/1022 ,  C12N9/88 ,  C12N9/93 ,  C12P13/02 ,  C12Y201/02011 ,  C12Y401/01011 ,  C12Y603/02001

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    Abstract translation: 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加关键中间体水平，通过有助于其合成的酶的酮托品来提高所需产物的生产的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。

    VITAMIN PROTOTROPHY AS A SELECTABLE MARKER
    10.
    发明申请
    VITAMIN PROTOTROPHY AS A SELECTABLE MARKER 有权
    VITAMIN PROTOTROPHY作为可选标记

    公开(公告)号：US20170016007A1

    公开(公告)日：2017-01-19

    申请号：US15285179

    申请日：2016-10-04

    Applicant: LanzaTech New Zealand Limited

    Inventor： Michael Koepke ,  Bakir Al-Sinawi

    IPC: C12N15/65 ,  C12N9/88 ,  C12N9/10 ,  C12N15/74

    CPC classification number: C12N15/65 ,  C12N1/20 ,  C12N9/1014 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12N15/74 ,  C12Y201/02011 ,  C12Y202/01011 ,  C12Y401/01011 ,  C12Y401/99017 ,  C12Y603/02001

    Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.

    Abstract translation: 用于维生素或其它必需营养物质的生物合成途径中的一个或多个基因可用作微生物存活所需的有效选择性标记，以鉴定用外源核酸转化的细胞。 微生物不天然含有或表达一个或多个基因。 这允许执行遗传操作。 它允许执行较低成本的发酵。 它允许生产用于随后商品使用的必需营养物质。

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