公开(公告)号：MX9803129A

公开(公告)日：1998-11-30

申请号：MX9803129

申请日：1998-04-21

Applicant: CYTOMETRICS INC

Inventor： GRONER WARREN ,  NADEAU RICHARD G

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145 ,  A61B5/1455 ,  G01N15/00 ,  G01N15/02 ,  G01N15/05 ,  G01N15/06 ,  G01N15/14 ,  G01N21/21 ,  G01N21/47 ,  G06F19/00 ,  A61B05/00 ,  A61B05/026

Abstract: La formacion de imagen reflejada se utiliza para realizar el análisis no invasor, in vivo del sistema vascular de un sujeto. Una imagen reflejada bruta (110) es normalizada con respecto al antecedente o fondo para formar una imagen reflejada corregida (120). Una imagen para análisis (130) es segmentada a partir de la imagen reflejada corregida, para incluir una escena o cuadro de interés para el análisis. El método y el aparato pueden ser utilizados para determinar características tales como la concentracion de hemoglobina por unidad de volumen de sangre, el numero de células sanguíneas blancas por unidad de volumen de sangre, un volumen celular medio, el numero de plaquetas por unidad de volumen de sangre, y el hematocrito. Puede ser utilizados polarizados cruzados (1510 y 1520) para mejorar la visualizacion de la imagen reflejada.

公开(公告)号：WO1996012438A1

公开(公告)日：1996-05-02

申请号：PCT/EP1995004095

申请日：1995-10-18

Applicant: R.D.C. - RAFAEL DEVELOPMENT CORPORATION LTD. ,  BRAUN, Ori ,  ROTTENBERG, Dan ,  HAIMOVICH, Dudu

Inventor： R.D.C. - RAFAEL DEVELOPMENT CORPORATION LTD. ,  BRAUN, Ori

IPC: A61B05/026

CPC classification number: A61B5/026

Abstract: A method for measuring the flow rate of a liquid, saline or blood, through a blood vessel to be used as graft on a patient in need thereof, where a certain quantity of this fluid is passed under controlled conditions through this vessel, thus establishing whether it is suitable for use as a graft. There is also provided a system for effecting such measurement which essentially comprises a large syringe connected to a pump, which passes the fluid through the blood vessel intended for use as graft, under exactly defined conditions, and means for calculating the flow rate and whether the vessel is suitable for the intended patient.

Abstract translation: 一种用于通过血管测量液体，盐水或血液的流量的方法，该血管用作有需要的患者的移植物，其中一定量的该液体在受控条件下通过该容器，从而确定 它适合用作移植物。 还提供了一种用于进行这种测量的系统，其基本上包括连接到泵的大型注射器，其在精确限定的条件下使流体通过旨在用作移植物的血管，以及用于计算流速的装置 血管适合预期的患者。

公开(公告)号：WO1991006244A1

公开(公告)日：1991-05-16

申请号：PCT/SE1990000705

申请日：1990-10-30

Applicant: NILSSON, Gert

IPC: A61B05/026

CPC classification number: A61B5/0261

Abstract: The invention relates to a system and to a method for the measurement and presentation of flow movements in a fluid, particularly for determining blood perfusion in the superficial blood vessels of a body organ. The system includes a laser beam generating source (1), means (3, 6) for directing the laser beam (2) onto the body part to be examined and for moving the laser beam in a controlled fashion over the body part in accordance with a determined scanning pattern (8). This system also includes means (9) for receiving part of the laser beam reflected from the body part. Also included in the system are means (10, 7) for detecting the broadened frequency of the reflected portion of the laser beam, this spectral broadening being caused by the Doppler effect, for a large number of points along the path (8) scanned by the laser beam, this broadening of the frequency being used as a measurement of the magnitude of the superficial blood circulation in the examined body part (5) at these points.

Abstract translation: 本发明涉及一种用于测量和呈现流体中的流动的系统和方法，特别是用于确定身体器官的浅表血管中的血液灌注。 该系统包括激光束产生源（1），用于将激光束（2）引导到待检查的身体部分上并用于以受控的方式将激光束移动到身体部分上的装置（3,6） 确定的扫描图案（8）。 该系统还包括用于接收从身体部分反射的一部分激光束的装置（9）。 还包括在系统中的装置（10,7）用于检测激光束的反射部分的加宽频率，该频谱变宽是由多普勒效应引起的，沿着沿着路径（8）扫描的路径（8）的大量点 激光束，这种频率的变宽被用作在这些点处检查的身体部分（5）中的浅表血液循环的量值的测量。

公开(公告)号：WO1990011044A1

公开(公告)日：1990-10-04

申请号：PCT/GB1990000459

申请日：1990-03-28

Applicant: NATIONAL RESEARCH DEVELOPMENT CORPORATION ,  BYRNE, Philip, Owen ,  ESSEX, Timothy, John, Hudson

Inventor： NATIONAL RESEARCH DEVELOPMENT CORPORATION

IPC: A61B05/026

CPC classification number: A61B5/0261

Abstract: A method of determination of blood flow including projecting a beam (B) of laser generated light (L) to move (SM) over a surface (T) beneath which blood flow in a vessel or vascular bed is to be determined, collecting (RD) light returning scattered from the beam by the surface and by blood flowing beneath, measuring a spectrum of frequencies in said collected light, determining (DA), (F) from differences in said frequencies blood flow (VS) in a vessel or vascular bed beneath said surface. A reference for the detected frequencies is provided by light returned from the surface. A map of blood flow in a false-colour flow scale can be displayed (DU).

公开(公告)号：WO1998018383A1

公开(公告)日：1998-05-07

申请号：PCT/AU1997000717

申请日：1997-10-24

Applicant: ROBINSON, Gavin, Joseph, Brian

IPC: A61B05/026

CPC classification number: A61B5/026 ,  A61B5/0813 ,  A61M16/04 ,  A61M16/0404 ,  A61M16/0459 ,  A61M16/0484 ,  A61M16/0486 ,  A61M2016/003 ,  A61M2202/0225

Abstract: The invention relates to a method and apparatus for determining pulmonary blood flow in a subject which utilises a divided airway, such that isolated divisions of the respiratory system which together make up the whole of the gas exchanging part of the respiratory system are ventilated with different gas mixtures. The invention also provides a triple lumen cuffed endobronchial catheter useful in measuring pulmonary blood flow.

Abstract translation: 本发明涉及一种用于确定受试者中肺血流量的方法和装置，该方法和装置利用分开的气道，使得呼吸系统的隔离部分组合在一起构成呼吸系统的整个气体交换部分，并以不同气体 混合物。 本发明还提供了一种用于测量肺血流量的三腔内套管支气管内导管。

公开(公告)号：WO1995028127A1

公开(公告)日：1995-10-26

申请号：PCT/US1995004644

申请日：1995-04-13

Applicant: ALLEGHENY-SINGER RESEARCH INSTITUTE ,  PACELLA, John, J. ,  CLARK, Richard, E.

Inventor： ALLEGHENY-SINGER RESEARCH INSTITUTE

IPC: A61B05/026

CPC classification number: A61M1/122 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1018 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/1087 ,  A61M1/12 ,  A61M1/127 ,  A61M39/228 ,  A61M2205/33 ,  A61M2205/3303

Abstract: The present invention pertains to a circulatory system (10), such as a circulatory assist system for a patient (12). The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump (14) can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device (16) for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions.

Abstract translation: 本发明涉及循环系统（10），例如用于患者（12）的循环辅助系统。 该系统包括具有与人的血管流体连通的管的血泵。 血液泵（14）可以是例如离心式血液泵，但不限于此。 该系统还包括用于控制血液泵流动的封堵装置（16）。 封堵装置与血液泵的管路接触。 封堵器装置可以并入血泵的出口移植管上的抗扭结护套中。 优选地，该系统包括用于当血液泵发生故障时致动封堵器装置的控制装置。

公开(公告)号：WO1995016392A1

公开(公告)日：1995-06-22

申请号：PCT/US1994013243

申请日：1994-11-23

Applicant: MODERN TECHNOLOGIES CORP.

Inventor： MODERN TECHNOLOGIES CORP. ,  SCHNURER, John, H. ,  FREUND, Robert

IPC: A61B05/026

CPC classification number: G01F1/64 ,  A61B5/026 ,  A61B5/027 ,  A61B5/742

Abstract: A method and apparatus for measuring the flow rates of fluids is disclosed. The apparatus comprises a probe (10) which may be placed in a fluid inside a vessel, such as a blood vessel. The probe (10) comprises at least one pair of conductors (16, 18) to which the circuit (15) provides a small current. As ions are disordered or migrate between at least one of the conductors and the fluid, a current or charge is caused to flow between the conductors (16, 18). The circuit (15) measures this current using a differential amplifier (66) and generates an output signal corresponding thereto. The output signal is then displayed on a monitor (80). Because the current flow is closely related to the rate of flow of the fluid past the probe, an accurate measurement of the flow rate is obtained.

Abstract translation: 公开了一种用于测量流体流速的方法和装置。 该装置包括探针（10），其可以放置在诸如血管的血管内的流体中。 探针（10）包括至少一对导体（16,18），电路（15）向其提供小电流。 由于离子在至少一个导体和流体之间无序或迁移，导致电流或电荷在导体（16,18）之间流动。 电路（15）使用差分放大器（66）测量该电流并产生与其对应的输出信号。 然后，输出信号显示在监视器（80）上。 由于目前的流量与通过探头的流体流速密切相关，所以可以获得流量的精确测量。

公开(公告)号：WO1992015241A1

公开(公告)日：1992-09-17

申请号：PCT/US1992001481

申请日：1992-02-27

Applicant: KENSEY NASH CORPORATION

Inventor： KENSEY NASH CORPORATION ,  CHO, Young ,  KENSEY, Kenneth

IPC: A61B05/026

CPC classification number: A61B5/02035 ,  A61B5/026 ,  A61B5/076

Abstract: Apparatus (20) and a method of determining in vivo the instantaneous velocity of the blood flowing within the body of a living being. The apparatus (20) basically comprises respective first and second sensors (42, 44) which are arranged to be disposed at spaced apart locations within a blood vessel (26). The sensors (42, 44) are coupled to a control/analysis unit (24) located externally of the body of the being. The first sensor (42) is arranged to provide a heat pulse to the blood flowing thereby and to provide a first signal at that time. The second sensor (44) is located downstream of said first sensor and is arranged for providing a second signal when the first blood portion passes thereby. The control/analysis unit (24) measures the time period between those signals and based on that value and data representative of the distance separating the sensors, calculates the instantaneous blood velocity.

Abstract translation: 装置（20）和体内确定在生物体内流动的血液的瞬时速度的方法。 设备（20）基本上包括相应的第一和第二传感器（42,44），其布置成设置在血管（26）内的间隔开的位置。 传感器（42,44）耦合到位于存在体的外部的控制/分析单元（24）。 第一传感器（42）被布置成向由此流动的血液提供加热脉冲，并且在此时提供第一信号。 第二传感器（44）位于所述第一传感器的下游，并且被布置用于当第一血液部分通过时提供第二信号。 控制/分析单元（24）测量这些信号之间的时间段，并且基于该值和表示分离传感器的距离的数据，计算瞬时血液速度。

公开(公告)号：WO1998020794A1

公开(公告)日：1998-05-22

申请号：PCT/GB1997003074

申请日：1997-11-07

Applicant: MOOR INSTRUMENTS LIMITED ,  BOGGETT, David ,  HUANG, Xiabing

Inventor： MOOR INSTRUMENTS LIMITED

IPC: A61B05/026

CPC classification number: A61B5/0261 ,  A61B5/7257 ,  G06F19/00

Abstract: An apparatus for measuring microvascular blood flow in tissue comprises means for irradiating a section of the tissue with the monochromatic light from the light source (2); means (2) for photodetecting the collected scattered light; means (3-6) for calculating the power spectrum of the photocurrents generated in the detection of laser light scattered from static tissue and Doppler broadened laser light scattered from moving blood cells. The apparatus includes means for filtering movement artefact noise and, therefore, enables fast tissue blood perfusion imaging with enhanced signal quality.

Abstract translation: 用于测量组织中微血管血流的装置包括用来自光源（2）的单色光照射组织的一部分的装置; 用于对收集的散射光进行光电检测的装置（2） 用于计算在从静电组织散射的激光的检测中产生的光电流的功率谱的计算机（3-6）和从移动的血细胞散射的多普勒加宽的激光。 该装置包括用于过滤运动伪影噪声的装置，因此能够实现具有增强的信号质量的快速组织血液灌注成像。

公开(公告)号：WO1998008434A1

公开(公告)日：1998-03-05

申请号：PCT/EP1997004725

申请日：1997-08-29

Applicant: PULSION VERW. GMBH & CO MEDICAL SYSTEMS KG ,  PFEIFFER, Ulrich, J. ,  KÜBLER, Wolfgang ,  GOETZ, Alwin, E.

Inventor： PULSION VERW. GMBH & CO MEDICAL SYSTEMS KG

IPC: A61B05/026

CPC classification number: A61B5/0275 ,  A61B5/0261 ,  A61B5/4064

Abstract: A process is disclosed for non-invasively measuring cerebral blood flow by simultaneously determining a blood flow index which is directly proportional to the blood flow. For that purpose, the cerebral flooding dynamics of an intravenously injected indicator dye with absorption properties in the near-infrared spectrum is sensed by near-infrared spectrocopy and the arterial flooding dynamics is sensed by pulse densitometry. A device used to carry out this process consists of a multiple channel apparatus with at least two near-infrared spectroscopes which have two pulsed monochromatic light sources each (with a measurement and a reference wavelength) in the range of the near-infrared spectrum, at least one or several light receivers connected to a photomultiplier, and a non-invasive measurement apparatus for the pulse densitometric determination of the tracer concentration in the arterial blood of the systemic blood circulation.

Abstract translation: ，通过近红外光谱和动脉来检测脑Anflutungskinetik与近红外光谱吸收特性的静脉内注射指示剂染料用于通过一正比于血流的血液流动指数同时测定脑血流的非侵入式测量的方法Anflutungskinetik装置Pulsdensitometrie和布置用于此目的 由多通道设备的具有至少两个近红外分光镜，每个由两个脉冲单色光源 - 一个测量和参照波长 - 在近红外光谱的区域中并且在每种情况下的一个或多个连接到一个光电倍增器的光感受器，和一个非 用于确定动脉血液体循环的pulsdensitometrischen示踪剂浓度侵入性测量装置。