公开(公告)号：US20040265507A1

公开(公告)日：2004-12-30

申请号：US10870643

申请日：2004-06-10

Inventor： Rong Xiong ,  Stephen Daniel Pastor ,  Patrice Bujard

IPC: B05D003/00

CPC classification number: C09C1/0015 ,  C01P2004/20 ,  C01P2004/54 ,  C01P2004/61 ,  C09C1/0018 ,  C09C1/0021 ,  C09C1/0024 ,  C09C1/0039 ,  C09C1/0051 ,  C09C1/0066 ,  C09C2200/1004 ,  C09C2200/1062 ,  C09C2200/301 ,  C09C2200/302 ,  C09C2200/303 ,  C09C2200/305 ,  C09C2200/306 ,  C09C2220/106 ,  C23C18/1212 ,  C23C18/1216 ,  C23C18/1225 ,  C23C18/1233 ,  C23C18/14

Abstract: A process for the preparation of organic material comprising an organic substrate and at least one dielectric layer consisting of one or more oxides of a metal selected from groups 3 to 15 of the periodic table, which comprises the steps of: (a) suspending the organic material in an aqueous solution of fluorine scavenger; (b) adding an aqueous solution of one or more fluorine containing metal complexes which are the precursors of the desired metal oxide coating; and (c) subjecting said suspension to microwave radiation to deposit the metal oxide onto said organic material, wherein steps (b) and (c) can optionally be repeated using different fluorine containing metal complexes to produce one or more metal oxide layers. The substrate can be optionally dissolved with solvent to yield free metal oxide or mixed metal oxides that have a plane-parallel structure.

Abstract translation: 一种制备有机材料的方法，包括有机基底和由选自周期表第3至15族的金属的一种或多种氧化物组成的至少一个介电层，其包括以下步骤：（a） 氟清除剂水溶液中的物质; （b）加入作为所需金属氧化物涂层的前体的一种或多种含氟金属络合物的水溶液; 和（c）使所述悬浮液经微波辐射将金属氧化物沉积到所述有机材料上，其中步骤（b）和（c）可以任选地使用不同的含氟金属络合物重复以产生一种或多种金属氧化物层。 底物可以任选地用溶剂溶解以产生具有平面平行结构的游离金属氧化物或混合金属氧化物。

公开(公告)号：US20040258834A1

公开(公告)日：2004-12-23

申请号：US10887154

申请日：2004-07-08

Applicant: Honeywell International Inc.

Inventor： Thomas Yui-Tai Tam ,  Jeffrey T. Perkins ,  Qiang Zhou ,  Arlin L. Fynaardt

IPC: B05D001/18 ,  B05D003/00

CPC classification number: D01D5/096

Abstract: Methods and devices are provided to actively apply finish to one or more yarns in motion at speeds greater than about 3000 m/min, to achieve a finish application of 0.2 wt. % or more, and with a coefficient of variation of finish concentration of 10% or less. The devices are compact, portable and readily installed at a variety of positions on a fiber processing line. The devices of the invention contain the finish so that contamination of the surrounding areas is prevented. The devices may be used to provide an overfinish to a moving yarn between heated godet rolls. The so-provided heating may be used to dry the yarn and to promote curing reactions in the finish and between the yarn and finish compounds. The invention also includes the finished yarn products so produced. A yarn with increased finish uniformity is provided with an overfinish actively applied and dried on the draw bench before the first winding operation. The yarn products of the invention may be used in textile and leisure fiber applications, and in industrial fiber applications, such as in tires.

公开(公告)号：US20040249438A1

公开(公告)日：2004-12-09

申请号：US10483321

申请日：2004-02-23

Inventor： Oliver Lefranc ,  Thierry Avramoglou ,  Jacqueline Jozefonvicz ,  Thierry Darnis ,  Michel Therin

IPC: B05D003/00

CPC classification number: A61L33/08 ,  A61L27/20 ,  A61L31/042

Abstract: The invention concerns a metal object for medical or surgical use, such as a prosthesis, for example an endovascular prosthesis (called stent) for percutaneous transluminal coronary angioplasty, comprising a metal substrate whereof the surface is coated partly at least with a polysaccharide compound. The invention is characterised in that the polysaccharide compound is covalently bound, via a plurality of grafting arms, comprising each at least a silane unit, bound on one side to the metal substrate by an nullOnull metal bond, and on the other side, directly or indirectly, by a covalent nullNHnull bond, with the polysaccharide compound.

Abstract translation: 本发明涉及用于医疗或外科用途的金属物体，例如假体，例如用于经皮腔内冠状动脉血管成形术的血管内假体（称为支架），包括金属基底，其表面部分地至少用多糖化合物涂覆。 本发明的特征在于多糖化合物通过多个接枝臂共价结合，所述多个接枝臂包含至少一个硅烷单元，其通过-O-金属键在一侧结合到金属基底上，另一侧， 直接或间接地通过共价的-NH-键与多糖化合物。

公开(公告)号：US20040248326A1

公开(公告)日：2004-12-09

申请号：US10494119

申请日：2004-07-29

Inventor： Babak Ziaie ,  Ronald A Siegel ,  Yuandong Gu ,  Antoni Baldi ,  Gauri P Misra ,  Paul E Loftness ,  Ming Lei

IPC: H01L021/00 ,  A61L002/00 ,  B05D003/00

CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61K47/34 ,  A61L29/145 ,  A61L29/16 ,  A61L31/145 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/80

Abstract: The invention provides hydrogel compositions, components, and hydrogel-actuated or mediated devices, and methods for the incorporation of hydrogel microscale components in microscale devices and systems. The methods and devices result in active microvalves that are useful in microfluidic applications, including analyte sensing, in process chemical and fermentation stream monitoring, and drug delivery. In particular, the devices are useful for controlled drug delivery either in response to a pre-determined stimulus or for pulsatile delivery.

Abstract translation: 本发明提供水凝胶组合物，组分和水凝胶致动或介导的装置，以及用于在微尺度装置和系统中结合水凝胶微量元件的方法。 这些方法和装置导致在微流体应用中有用的活性微血管，包括分析物感测，在过程化学和发酵流监测和药物递送。 特别地，所述装置可用于响应于预先确定的刺激或用于脉动递送的受控药物递送。

公开(公告)号：US20040247776A1

公开(公告)日：2004-12-09

申请号：US10483139

申请日：2004-07-21

Inventor： Staffan Folestad ,  Ingela Niklasson Bjorn ,  Daniel Strom

IPC: B05D003/00

CPC classification number: B05B17/0607 ,  A61K9/2893 ,  B01J2/006 ,  B01J2/16 ,  B05B7/0012

Abstract: The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).

Abstract translation: 本发明涉及药物包衣的方法。 该方法包括用至少一个微分配器（1）产生具有受控尺寸，形状和组成的离散液滴（7）的步骤，并以受控的速度，飞行时间分布液滴（7）。 此外，该方法包括控制液滴的生产频率和调制的步骤（7）。 此外，该方法包括控制载气的流速，温度和组成并将液滴（7）引向经受涂覆的颗粒（10）的步骤。 本发明还涉及一种用于涂覆药物的装置。 该装置包括液滴产生单元（1）和液滴引导单元（8）。 液滴产生单元（1）是用于产生离散液滴（7）并控制所述液滴（7）的尺寸，形状和组成的压电致动微型分配器（1）。

公开(公告)号：US20040241881A1

公开(公告)日：2004-12-02

申请号：US10845026

申请日：2004-05-14

Inventor： Rex J. Kuriger

IPC: G01N033/543 ,  B05D003/00

CPC classification number: G01N33/525 ,  A61B5/14532 ,  A61B5/1455 ,  B01L3/5027 ,  B01L3/502707 ,  G01N21/78 ,  G01N27/3272 ,  Y10T156/1052 ,  Y10T156/1054

Abstract: According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.

Abstract translation: 根据本发明的一个实施例，公开了一种用于测定液体样品中的分析物的光学测试传感器。 测试传感器包括基底，聚合物载体和测试膜。 底座具有形成在基座的表面中的毛细通道，其适于将液体样品从入口移动到形成在基部中的反应区域。 聚合物载体具有粘附到基底表面的下表面，并设置在毛细通道的至少一部分上。 包含试剂的测试膜粘附到聚合物载体的下表面，并从聚合物载体延伸到反应区域中。

公开(公告)号：US20040241724A1

公开(公告)日：2004-12-02

申请号：US10806028

申请日：2004-03-22

Applicant: Biacore AB

Inventor： Robert Karlsson ,  Anders Sjodin

IPC: C12Q001/68 ,  C12M001/34 ,  B05D003/00

CPC classification number: G01N33/5432 ,  G01N33/548

Abstract: A method of immobilizing a target molecule to a solid support surface capable of interacting with the target molecule is disclosed. The method comprises the steps of complexing the target molecule with a vesicular structure capable of forming a dissociable complex with the target molecule, contacting the complex formed with the solid support surface to thereby bind the target molecule to the surface, dissociating the complex, and removing the vesicular structure from the solid support surface to leave the target molecule immobilized on the surface. A method of sensitizing a solid support surface, the use of the sensitized solid support surface for analyzing analytes, and a reagent kit for carrying out the method are also disclosed.

Abstract translation: 公开了将目标分子固定在能够与靶分子相互作用的固体支持体表面上的方法。 该方法包括以下步骤：使目标分子与能够与靶分子形成可离解复合物的囊泡结构相接触，使与固体支持物表面形成的复合物接触，从而将靶分子结合到表面，解离复合物，并除去 来自固体支持体表面的水泡结构，使靶分子固定在表面上。 还公开了使固体支持体表面敏化的方法，使用敏化固体支持体表面分析分析物，以及用于实施该方法的试剂盒。

公开(公告)号：US20040235146A9

公开(公告)日：2004-11-25

申请号：US10297244

申请日：2003-06-30

Inventor： Stefan Dickopf ,  Holger Ottleben ,  Harald Rau ,  Renate Sekul ,  Kristina Schmidt ,  Dirk Vetter

IPC: C12M001/34 ,  B05D003/00

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  B82Y15/00 ,  G01N33/54353 ,  G01N33/553

Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.

公开(公告)号：US20040235033A1

公开(公告)日：2004-11-25

申请号：US10845643

申请日：2004-05-14

Applicant: Affymetrix, Inc.

Inventor： Alejandro C. Zaffaroni ,  Christopher J. Buchko ,  Douglas N. Modlin

IPC: C12Q001/68 ,  B05D003/00 ,  G01N033/53 ,  G01N001/30 ,  G01N033/48

CPC classification number: B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01L2300/0893 ,  C40B60/14 ,  G01N2035/1039 ,  Y10T436/111666 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.

Abstract translation: 提供了一种用于在具有快速可及位置的基底上制备和使用非常大且多样化的化合物阵列的装置和方法。 底物含有阵列化合物所在的细胞。 围绕细胞是不可润湿的表面，其防止一个细胞中的溶液移动到相邻的细胞。 通过连接到X-Y平台的微量移液管将化合物递送到阵列的各个细胞。

公开(公告)号：US20040224857A1

公开(公告)日：2004-11-11

申请号：US10805400

申请日：2004-03-19

Inventor： Hendrik John

IPC: C10M125/00 ,  A61L002/00 ,  B05D003/00

CPC classification number: F16L15/001 ,  C08K3/16 ,  C09D5/033 ,  C09D5/448 ,  C09D7/61 ,  E21B17/042 ,  F16L58/182

Abstract: A method for controlling galling including applying a composition of about 3.5 to about 36 wt %, based upon the total weight of the composition of a fluoridic or oxidic compound of a transition of alkaline earth metal; about 4 to about 96.5 wt %, based upon the total weight of the composition, of an adherent and about 0 to about 65 wt %, based upon the total weight of the composition, of a solvent contact area of a member. An antigalling coating composition having about 3.5 to about 36 wt %, based upon the total weight of the composition, of a fluoridic or oxidic compound of a transition or alkaline earth metal; about 4 to about 96.5 wt %, based upon the total weight of the composition, of an adherent and about 0 to about 65 wt %, based upon the total weight of the composition, of a solvent.

Abstract translation: 用于控制磨损的方法，包括施用约3.5至约36重量％的组合物，基于组合物的总重量，碱土金属的过渡的氟化物或氧化化合物; 基于组合物的总重量，约4至约96.5重量％的粘合剂和约0至约65重量％，基于组合物的总重量，构件的溶剂接触面积。 基于组合物的总重量，具有约3.5至约36重量％的抗过氧化涂料组合物的过渡金属或碱土金属的氟化物或氧化化合物; 基于组合物的总重量，约4至约96.5重量％的粘合剂和约0至约65重量％，基于组合物的总重量，溶剂。