公开(公告)号：WO2023278672A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035684

申请日：2022-06-30

Applicant: Q-STATE BIOSCIENCES, INC.

Inventor： BORJA, Gabriel, Benito ,  LU, Yang ,  HARWOOD, Benjamin ,  ZHANG, Hongkang ,  WERLEY, Christopher ,  MCMANUS, Owen ,  DEMPSEY, Graham, T.

IPC: G01N21/63 ,  G01N21/19 ,  G01N33/50 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L9/523 ,  G01N21/01 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2201/02 ,  G01N2201/0636

Abstract: The invention provides a multi-well plate reader for providing simultaneous transmission of stimulation light to, and detection of emission light from, individual wells of a multi-well plate at a plurality of distinct wavelengths.

公开(公告)号：WO2021086766A2

公开(公告)日：2021-05-06

申请号：PCT/US2020/057278

申请日：2020-10-26

Applicant: CORNING INCORPORATED

Inventor： ANDREWS, Ryan Claude ,  ROUSSEV, Rostislav Vatchev ,  TREIKALIS, Antons ,  YANG, Ming

IPC: G01N21/23 ,  G01L1/24 ,  G01N21/43 ,  G01N33/38 ,  G01N21/41 ,  G01N21/84 ,  G01N2201/02 ,  G01N2201/0635 ,  G01N2201/125

Abstract: The prism-coupling systems and methods include using a prism-coupling system to collect a 2D digital mode spectrum of an IOX article. The mode line and critical angle positions and orientations are found by performing a weighted fit to mode line and critical angle images and are used to define a compensated mode spectrum. If mode line tilt is found, it is removed from the 2D digital mode spectrum to define the compensated mode spectrum. The compensated mode spectrum is then processed using techniques known in the art to provide a more accurate estimate of stress-related characteristics of the IOX sample versus using the uncompensated mode spectrum. Derivative-based methods of accurately establishing positions of intensity transitions in a mode spectrum of an IOX sample using a derivative spectrum and curve fitting are also disclosed.