公开(公告)号：EP2731576B1

公开(公告)日：2018-10-10

申请号：EP12866437.2

申请日：2012-07-11

Applicant: Owl Biomedical, Inc. ,  Innovative Micro Technology

Inventor： FOSTER, John, S. ,  GRUMMITT, Daryl, W. ,  HARLEY, John, C. ,  LINTON, James, P. ,  SPONG, Jaquelin, K.

IPC: A61J1/06 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N15/14

CPC classification number: C12M47/04 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N15/1459 ,  G01N2015/149

Abstract: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.

公开(公告)号：EP1941254B1

公开(公告)日：2011-11-23

申请号：EP06816837.6

申请日：2006-10-12

Applicant: Innovative Micro Technology ,  Foster, John S. ,  Harley, John C. ,  Martin, Richard T. ,  Nguyen, Hung D. ,  Rubel, Paul John

Inventor： FOSTER, John, S. ,  HARLEY, John, C. ,  MARTIN, Richard, T. ,  NGUYEN, Hung ,  RUBEL, Paul, J.

IPC: G01N1/10 ,  G01N21/64 ,  A61M1/36

CPC classification number: B01L3/502707 ,  A61M1/3633 ,  A61M1/3678 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0864 ,  B01L2400/0484 ,  C12M47/04 ,  G01N21/6428 ,  G01N2015/0288 ,  G01N2015/149 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

Abstract: A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent signal emanating from the component of interest. The two-part actuator may include a force-generating portion (350) and a microactuator portion (330). The microactuator portion (330) may be disposable, whereas the force-generating portion (350) may be reuseable. By bringing the force-generating portion (350) into proximity to the microactuator portion (330), the microactuator (300) is induced to move, thereby separating the component of interest from the rest of the fluid stream. The force-generating portion (350) and the microactuator portion (330) may be optimized and fabricated separately, thereby leading to faster, more reliable and less expensive particle sorting.

公开(公告)号：EP1910800A2

公开(公告)日：2008-04-16

申请号：EP06800528.9

申请日：2006-07-31

Applicant: Innovative Micro Technology ,  Foster, John S. ,  Harley, John C. ,  Hovey, Steven H. ,  Martin, Richard T. ,  Nguyen, Hung D. ,  Rubel, Paul John

Inventor： FOSTER, John S. ,  HARLEY, John C. ,  HOVEY, Steven H. ,  MARTIN, Richard T. ,  NGUYEN, Hung ,  RUBEL, Paul J.

IPC: G01N1/10 ,  G01N21/64

CPC classification number: C12M47/04 ,  A61M1/36 ,  A61M1/3633 ,  A61M1/3678 ,  A61M2202/0437 ,  B01L3/5027 ,  G01N21/6428 ,  G01N2015/0288 ,  G01N2015/149 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

Abstract: A micromechanical particle sorting chip (300) uses laser light (305) directed through at least one of a reflective (360) and refractive (310) surface to come to a focus (320) in an optically transparent layer. The laser light (305) impinges on a particle of interest, causing it to fluoresce. Upon detecting the fluorescence, a micromechanical actuator (400) is activated, which directs the particle of interest into one of a plurality of possible exit paths.

公开(公告)号：EP1910800A4

公开(公告)日：2013-03-06

申请号：EP06800528

申请日：2006-07-31

Applicant: INNOVATIVE MICRO TECHNOLOGY ,  FOSTER JOHN S ,  HARLEY JOHN C ,  HOVEY STEVEN H ,  MARTIN RICHARD T ,  NGUYEN HUNG D ,  RUBEL PAUL JOHN

Inventor： FOSTER JOHN S ,  HARLEY JOHN C ,  HOVEY STEVEN H ,  MARTIN RICHARD T ,  NGUYEN HUNG ,  RUBEL PAUL J

IPC: G01N1/10 ,  A61M1/36 ,  B01L3/00 ,  C12M1/34 ,  C12Q1/00 ,  G01N15/02 ,  G01N21/05 ,  G01N21/64 ,  H01L21/00

CPC classification number: C12M47/04 ,  A61M1/36 ,  A61M1/3633 ,  A61M1/3678 ,  A61M2202/0437 ,  B01L3/5027 ,  G01N21/6428 ,  G01N2015/0288 ,  G01N2015/149 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

公开(公告)号：EP1941254A4

公开(公告)日：2010-09-15

申请号：EP06816837

申请日：2006-10-12

Applicant: INNOVATIVE MICRO TECHNOLOGY ,  FOSTER JOHN S ,  HARLEY JOHN C ,  MARTIN RICHARD T ,  NGUYEN HUNG D ,  RUBEL PAUL JOHN

Inventor： FOSTER JOHN S ,  HARLEY JOHN C ,  MARTIN RICHARD T ,  NGUYEN HUNG ,  RUBEL PAUL J

IPC: G01N1/10 ,  A61M1/36 ,  B01L3/00 ,  C12M1/34 ,  C12Q1/00 ,  G01N15/02 ,  G01N21/05 ,  G01N21/64 ,  H01L21/00

CPC classification number: B01L3/502707 ,  A61M1/3633 ,  A61M1/3678 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0864 ,  B01L2400/0484 ,  C12M47/04 ,  G01N21/6428 ,  G01N2015/0288 ,  G01N2015/149 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

公开(公告)号：EP1961036B1

公开(公告)日：2016-07-20

申请号：EP06844592.3

申请日：2006-11-29

Applicant: Innovative Micro Technology

Inventor： CARLSON, Gregory, A. ,  ERLACH, David, M. ,  PARANJPYE, Alok ,  SUMMERS, Jeffery, F.

IPC: H01L21/00 ,  B81C1/00 ,  H01L23/10

CPC classification number: B81C1/00269 ,  B81C2203/0118 ,  B81C2203/019 ,  H01L23/10 ,  H01L2924/0002 ,  H01L2924/01079 ,  H01L2924/00

公开(公告)号：EP3027781A1

公开(公告)日：2016-06-08

申请号：EP14832320.7

申请日：2014-06-30

Applicant: Innovative Micro Technology

Inventor： ZEYEN, Benedikt

IPC: C21D1/04 ,  G01R33/06

CPC classification number: G01R33/0052 ,  G01R33/0011 ,  Y10T29/4902

Abstract: A microfabricated magnetic field transducer uses a magnetically sensitive structure in combination with one or more permeable magnetic flux guides. The flux guides may route off-axis components of an externally applied magnetic field across the sensitive axis of the magnetically sensitive structure, or may shield the magnetically sensitive structure from off-axis, stray fields or noise sources. A combination of flux guides and magnetically sensitive structures arranged on a single substrate may enable an integrated, 3-axis magnetometer in a single package, greatly improving cost and performance.

Abstract translation: 微制造的磁场传感器使用与一个或多个可渗透的磁通导向器组合的磁敏结构。 磁通引导件可以将外部施加的磁场的偏轴分量穿过磁敏结构的敏感轴线，或者可以将磁敏结构屏蔽到离轴，杂散场或噪声源。 布置在单个基板上的磁通引导件和磁敏结构的组合可以使单个封装中的集成的3轴磁力计可以大大提高成本和性能。

公开(公告)号：EP1961036A1

公开(公告)日：2008-08-27

申请号：EP06844592.3

申请日：2006-11-29

Applicant: Innovative Micro Technology ,  Carlson, Gregory A. ,  Erlach, David M. ,  Paranjpye, Alok ,  Summers, Jeffrey F.

Inventor： CARLSON, Gregory, A. ,  ERLACH, David, M. ,  PARANJPYE, Alok ,  SUMMERS, Jeffery, F.

IPC: H01L21/00

CPC classification number: B81C1/00269 ,  B81C2203/0118 ,  B81C2203/019 ,  H01L23/10 ,  H01L2924/0002 ,  H01L2924/01079 ,  H01L2924/00

Abstract: Systems and methods for forming an encapsulated device include a hermetic seal which seals an insulating environment between two substrates, one of which supports the device. The hermetic seal is formed by an alloy of two metal layers, one deposited on a first substrate and the other deposited on the second substrate, along with a raised feature formed on the first or the second substrate. At least one of the metal layers may be deposited conformally over the raised feature. The raised feature penetrates the molten material of the first or the second metal layers during formation of the alloy, and produces a spectrum of stoichiometrics for the formation of the desired alloy, as a function of the distance from the raised feature. At some distance from the raised feature, the proper ratio of the first metal to the second metal exists to form an alloy of the preferred stoichiometry.

公开(公告)号：EP2731576A4

公开(公告)日：2015-04-29

申请号：EP12866437

申请日：2012-07-11

Applicant: OWL BIOMEDICAL INC ,  INNOVATIVE MICRO TECHNOLOGY

Inventor： FOSTER JOHN S ,  GRUMMITT DARYL W ,  HARLEY JOHN C ,  LINTON JAMES P ,  SPONG JAQUELIN K

IPC: A61J1/06 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N15/14

CPC classification number: C12M47/04 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N15/1459 ,  G01N2015/149

Abstract: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.

公开(公告)号：EP2731576A1

公开(公告)日：2014-05-21

申请号：EP12866437.2

申请日：2012-07-11

Applicant: Owl Biomedical, Inc. ,  Innovative Micro Technology ,  Foster, John S. ,  Grummit, Daryl W. ,  Harley, John C. ,  Linton, James P. ,  Spong, Jaquelin K.

Inventor： FOSTER, John, S. ,  GRUMMITT, Daryl, W. ,  HARLEY, John, C. ,  LINTON, James, P. ,  SPONG, Jaquelin, K.

IPC: A61J1/06

CPC classification number: C12M47/04 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N15/1459 ,  G01N2015/149

Abstract: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.

Abstract translation: 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的对应微流体通路连接的通路。 柔性垫圈可以防止泄漏并且允许流体穿过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜以允许空气逸出并且通过皮下注射针插入流体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。