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    FABRICATION METHOD FOR STRATIFIED AND LAYERED TISSUE TO REPAIR OSTEOCHONDRAL DEFECTS
    1.
    发明申请
    FABRICATION METHOD FOR STRATIFIED AND LAYERED TISSUE TO REPAIR OSTEOCHONDRAL DEFECTS 有权
    分层和层状组织修复骨质疏松症的制造方法

    公开(公告)号：US20140242140A1

    公开(公告)日：2014-08-28

    申请号：US14194207

    申请日：2014-02-28

    Applicant: Purdue Research Foundation

    Inventor： Corey P. Neu ,  Tyler A. Novak ,  Garrett Shannon

    IPC: A61K38/39

    CPC classification number: A61K38/39

    Abstract: Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer.

    Abstract translation: 分层和层状组织修复骨软骨缺损的制备方法。 在本公开的方法中，该方法包括以下步骤：向第一量的第一胶原溶液施加第一方向磁场，以使第一胶原溶液中的胶原相对于第一方向磁场在第一方向上，形成 第一层胶原蛋白。 在产生本公开的对准的胶原层的方法中，所述方法包括在等于或在2℃的温度下，将等于或大于0.1特斯拉的第一磁场施加到限定水平面的第一胶原溶液层 和45℃，以产生对准的胶原层。

    AFM-coupled microscale radiofrequency probe for magnetic resonance imaging and spectroscopy
    2.
    发明授权
    AFM-coupled microscale radiofrequency probe for magnetic resonance imaging and spectroscopy 有权
    用于磁共振成像和光谱的AFM耦合微型射频探头

    公开(公告)号：US08884608B2

    公开(公告)日：2014-11-11

    申请号：US14351055

    申请日：2012-10-10

    Applicant: Purdue Research Foundation

    Inventor： Corey P. Neu ,  Babak Ziaie ,  Teimour Maleki-Jafarabadi ,  Charilaos Mousoulis

    IPC: G01R33/12 ,  G01R33/20 ,  G01N24/08 ,  G01Q70/16 ,  G01Q30/02 ,  G01R33/48

    CPC classification number: G01R33/4808 ,  G01N24/08 ,  G01Q20/04 ,  G01Q30/02 ,  G01Q60/08 ,  G01Q60/52 ,  G01Q70/16 ,  G01R33/341 ,  G01R33/46

    Abstract: The present disclosure is discloses the development of a new device, system, and method that combines advantages of magnetic resonance and atomic force microscopy technologies, and the utility of the new device, system, and method for a wide range of biomedical and clinical researchers. According to one aspect of the present disclosure, a device for micro-scale spectroscopy is disclosed. The micro-scale spectroscopy device includes a beam having a distal end, a proximal end, a top surface and a bottom surface, where the beam is attached to an anchor at the proximal end and further includes a tip extending substantially perpendicular from the bottom surface at or near the distal end, and a coil having at least one turn mounted to the top surface of the beam at or near the distal end opposite the tip, where the coil is capable of both transmitting and sensing electromagnetic radiation.

    Abstract translation: 本公开公开了一种结合磁共振和原子力显微技术的优点的新器件，系统和方法的开发，以及用于广泛的生物医学和临床研究者的新器件，系统和方法的实用性。 根据本公开的一个方面，公开了一种用于微尺度光谱的装置。 微型光谱装置包括具有远端，近端，顶表面和底表面的光束，其中光束附接到近端处的锚固件，并且还包括从底表面基本垂直延伸的尖端 在远端处或附近，以及具有至少一个匝的线圈，其安装到梁的顶表面处，或者与尖端相对的远端附近，其中线圈能够传输和感测电磁辐射。

    Fabrication method for stratified and layered tissue to repair osteochondral defects
    4.
    发明授权
    Fabrication method for stratified and layered tissue to repair osteochondral defects 有权

    公开(公告)号：US09616110B2

    公开(公告)日：2017-04-11

    申请号：US14194207

    申请日：2014-02-28

    Applicant: Purdue Research Foundation

    Inventor： Corey P. Neu ,  Tyler A. Novak ,  Garrett Shannon

    IPC: A61K38/39

    CPC classification number: A61K38/39

    Abstract: Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer.

    AFM-COUPLED MICROSCALE RADIOFREQUENCY PROBE FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
    5.
    发明申请
    AFM-COUPLED MICROSCALE RADIOFREQUENCY PROBE FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY 有权
    用于磁共振成像和光谱的AFM耦合微结构无线电探头

    公开(公告)号：US20140237690A1

    公开(公告)日：2014-08-21

    申请号：US14351055

    申请日：2012-10-10

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Corey P. Neu ,  Babak Ziaie ,  Teimour Maleki-Jafarabadi ,  Charilaos Mousoulis

    IPC: G01R33/48 ,  G01Q70/16 ,  G01Q30/02

    CPC classification number: G01R33/4808 ,  G01N24/08 ,  G01Q20/04 ,  G01Q30/02 ,  G01Q60/08 ,  G01Q60/52 ,  G01Q70/16 ,  G01R33/341 ,  G01R33/46

    Abstract: The present disclosure is discloses the development of a new device, system, and method that combines advantages of magnetic resonance and atomic force microscopy technologies, and the utility of the new device, system, and method for a wide range of biomedical and clinical researchers. According to one aspect of the present disclosure, a device for micro-scale spectroscopy is disclosed. The micro-scale spectroscopy device includes a beam having a distal end, a proximal end, a top surface and a bottom surface, where the beam is attached to an anchor at the proximal end and further includes a tip extending substantially perpendicular from the bottom surface at or near the distal end, and a coil having at least one turn mounted to the top surface of the beam at or near the distal end opposite the tip, where the coil is capable of both transmitting and sensing electromagnetic radiation.

    Abstract translation: 本公开公开了一种结合磁共振和原子力显微技术的优点的新器件，系统和方法的开发，以及用于广泛的生物医学和临床研究人员的新器件，系统和方法的实用性。 根据本公开的一个方面，公开了一种用于微尺度光谱的装置。 微型光谱装置包括具有远端，近端，顶表面和底表面的光束，其中光束附接到近端处的锚固件，并且还包括从底表面基本垂直延伸的尖端 在远端处或附近，以及具有至少一个匝的线圈，其安装到梁的顶表面处，或者与尖端相对的远端附近，其中线圈能够传输和感测电磁辐射。

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