公开(公告)号：US20140242140A1

公开(公告)日：2014-08-28

申请号：US14194207

申请日：2014-02-28

Applicant: Purdue Research Foundation

Inventor： Corey P. Neu ,  Tyler A. Novak ,  Garrett Shannon

IPC: A61K38/39

CPC classification number: A61K38/39

Abstract: Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer.

Abstract translation: 分层和层状组织修复骨软骨缺损的制备方法。 在本公开的方法中，该方法包括以下步骤：向第一量的第一胶原溶液施加第一方向磁场，以使第一胶原溶液中的胶原相对于第一方向磁场在第一方向上，形成 第一层胶原蛋白。 在产生本公开的对准的胶原层的方法中，所述方法包括在等于或在2℃的温度下，将等于或大于0.1特斯拉的第一磁场施加到限定水平面的第一胶原溶液层 和45℃，以产生对准的胶原层。

公开(公告)号：US09616110B2

公开(公告)日：2017-04-11

申请号：US14194207

申请日：2014-02-28

Applicant: Purdue Research Foundation

Inventor： Corey P. Neu ,  Tyler A. Novak ,  Garrett Shannon

IPC: A61K38/39

CPC classification number: A61K38/39

Abstract: Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer.