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公开(公告)号:US20250160648A1
公开(公告)日:2025-05-22
申请号:US19024995
申请日:2025-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.
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公开(公告)号:US20220092770A1
公开(公告)日:2022-03-24
申请号:US17423449
申请日:2020-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Danielle Dunham
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号:US20250160650A1
公开(公告)日:2025-05-22
申请号:US19025507
申请日:2025-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.
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公开(公告)号:US20250069224A1
公开(公告)日:2025-02-27
申请号:US18943247
申请日:2024-11-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Danielle Dunham
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号:US12141964B2
公开(公告)日:2024-11-12
申请号:US17423449
申请日:2020-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Danielle Dunham
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号:US20250160649A1
公开(公告)日:2025-05-22
申请号:US19025446
申请日:2025-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.
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公开(公告)号:US20250152010A1
公开(公告)日:2025-05-15
申请号:US19025440
申请日:2025-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.
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8.
公开(公告)号:US20240366090A1
公开(公告)日:2024-11-07
申请号:US18662750
申请日:2024-05-13
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
Abstract: A portable imaging system for visualizing bacteria in a wound in real time includes an excitation light source configured to emit violet and/or blue excitation light to illuminate a wound and cause at least one biomarker associated with the wound to fluoresce and a camera configured to detect fluorescence emitted by the at least one biomarker associated with the wound in response to illumination of the wound with the excitation light. A portable frame is configured to support the camera and the excitation light source for hands-free operation and to position the camera and the excitation light source relative to the wound. The system also includes a power source for the excitation light source.
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9.
公开(公告)号:US20240293029A1
公开(公告)日:2024-09-05
申请号:US18662583
申请日:2024-05-13
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
CPC classification number: A61B5/0071 , A61B5/0059 , A61B5/01 , A61B5/445 , A61B5/72 , A61B5/742 , G01N21/6456 , G01N21/6486 , A61B5/0042 , A61B5/4519 , A61B10/00 , G01N21/6408 , G01N2021/6421 , G01N2021/6471 , G01N2201/0221 , Y02A90/10
Abstract: A method of visualizing bacteria in real time includes positioning a portable frame of a portable imaging system relative to a target, wherein the portable imaging system includes a camera and an excitation light source mounted on the portable frame, operating the portable imaging system in a hands-free manner to illuminate the target with excitation light having at least one wavelength to cause at least one biomarker associated with the target to fluoresce and to detect fluorescence of the at least one biomarker with the camera.
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