公开(公告)号：US20240100226A1

公开(公告)日：2024-03-28

申请号：US18380350

申请日：2023-10-16

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Adam E. JAKUS ,  Ramille N. SHAH ,  Nicholas R. GEISENDORFER

IPC: A61L27/56 ,  A61L27/18 ,  A61L27/44 ,  C08J9/26 ,  C08L67/04

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/446 ,  C08J9/26 ,  C08L67/04 ,  C08J2201/03 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2367/04

Abstract: Compositions for forming porous materials and three-dimensional objects, including fibers, films and coatings made from the materials are provided. Also provided are methods for forming the porous objects from the compositions. The compositions include a solvent, a polymer binder that is soluble in the solvent, and solid particles that are insoluble in the solvent. The solid particles include water-soluble salt particles that can be selectively dissolved from objects made from the compositions to render the resulting structures porous.

公开(公告)号：US10034894B2

公开(公告)日：2018-07-31

申请号：US15635517

申请日：2017-06-28

Applicant: CytoSorbents Corporation

Inventor： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61K31/745 ,  A61K9/16 ,  A61K9/50 ,  C08J9/26 ,  B01J20/26 ,  B01J20/30 ,  A61K9/00 ,  B01J20/28 ,  C08F212/36 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58

CPC classification number: A61K31/745 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/50 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/3064 ,  C08F212/36 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2325/02 ,  Y02A50/406 ,  Y02A50/411

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：US10010821B2

公开(公告)日：2018-07-03

申请号：US14753354

申请日：2015-06-29

Applicant: Anil K. Sadana

Inventor： Anil K. Sadana

IPC: B01D39/16 ,  B01D71/36 ,  E21B43/02 ,  E21B43/12 ,  E21B43/38 ,  C08J9/26 ,  B29C67/20 ,  B01D29/00 ,  B01D67/00 ,  B29B7/88 ,  B29B11/12 ,  B29B13/02 ,  B29K27/12 ,  B29K105/00 ,  B29K105/04

CPC classification number: B01D39/1661 ,  B01D29/0093 ,  B01D29/0095 ,  B01D39/1692 ,  B01D67/0004 ,  B01D67/003 ,  B01D71/36 ,  B29B7/88 ,  B29B11/12 ,  B29B13/02 ,  B29C67/202 ,  B29K2027/12 ,  B29K2105/0005 ,  B29K2105/04 ,  B29K2105/251 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0444 ,  C08J2327/12 ,  C08J2327/18 ,  E21B43/02 ,  E21B43/12 ,  E21B43/38

Abstract: A rigid flow control device includes a porous rigid body having an outer surface and an inner surface. The body defines a flow path and is formed from a material operatively arranged with a surface energy less than that of the fluid for passively impeding an undesirable component of the fluid more than a desirable component of the fluid.

公开(公告)号：US20180077925A1

公开(公告)日：2018-03-22

申请号：US15554681

申请日：2016-03-07

Applicant: John Paul WILSON

Inventor： John Paul WILSON

IPC: A01N25/16 ,  A01N59/20 ,  A01N25/10 ,  A01N59/16 ,  C08J9/26 ,  C08J9/00 ,  C08K3/08 ,  A47L13/17 ,  A47L13/51

CPC classification number: A01N25/16 ,  A01N25/10 ,  A01N59/16 ,  A01N59/20 ,  A47L13/17 ,  A47L13/51 ,  C08J9/0004 ,  C08J9/0014 ,  C08J9/0066 ,  C08J9/26 ,  C08J9/40 ,  C08J2201/036 ,  C08J2201/038 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2201/046 ,  C08J2205/06 ,  C08J2207/00 ,  C08J2207/12 ,  C08J2300/24 ,  C08J2301/02 ,  C08J2301/24 ,  C08J2321/00 ,  C08J2355/02 ,  C08K3/08 ,  C08K2003/0806 ,  C08K2003/085

Abstract: A method of manufacturing a flexible intrinsically antimicrobial absorbent porosic composite controlling for an effective pore size using removable pore-forming substances and physically incorporated, non-leaching antimicrobials. A flexible intrinsically antimicrobial absorbent porosic composite controlled for an effective pore size composited physically incorporated, high-surface area, non-leaching antimicrobials, optionally in which the physically incorporated non-leaching antimicrobial exposes nanopillars on its surface to enhance antimicrobial activity. A kit that enhances the effectiveness of the intrinsically antimicrobial absorbent porosic composite by storing the composite within an antimicrobial container.

公开(公告)号：US20170296696A1

公开(公告)日：2017-10-19

申请号：US15434484

申请日：2017-02-16

Applicant: Trustees of Tufts College

Inventor： David L. Kaplan ,  Ung-Jin Kim ,  Jaehyung Park ,  Hyoung-Joon Jin

IPC: A61L27/22 ,  D01D5/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B29C39/00 ,  B29C39/20 ,  B29C55/00 ,  B29D7/01 ,  C07K14/435 ,  C08L89/00 ,  C08J9/28 ,  C08J9/26 ,  C08J9/00 ,  C08J5/18 ,  C08J3/075 ,  C08J3/07 ,  D01F4/02 ,  B29L7/00 ,  B29L9/00

CPC classification number: A61L27/227 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/02 ,  B29C39/003 ,  B29C39/203 ,  B29C55/005 ,  B29D7/01 ,  B29K2089/00 ,  B29L2007/00 ,  B29L2009/00 ,  C07K14/43536 ,  C07K14/43586 ,  C08J3/07 ,  C08J3/075 ,  C08J5/18 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2389/00 ,  C08L89/00 ,  D01D5/0007 ,  D01F4/02 ,  Y10T428/249921 ,  Y10T442/10 ,  Y10T442/60

Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

公开(公告)号：US20170296574A1

公开(公告)日：2017-10-19

申请号：US15635517

申请日：2017-06-28

Applicant: CytoSorbents Corporation

Inventor： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

IPC: A61K31/745 ,  A61K9/16 ,  A61K9/50 ,  C08J9/26 ,  B01J20/26 ,  B01J20/30 ,  A61K9/00 ,  B01J20/28 ,  C08F212/36

CPC classification number: A61K31/745 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/50 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/3064 ,  C08F212/36 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2325/02 ,  Y02A50/406 ,  Y02A50/411

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：US09452372B2

公开(公告)日：2016-09-27

申请号：US13654726

申请日：2012-10-18

Applicant: Anil K. Sadana

Inventor： Anil K. Sadana

IPC: B27J5/00 ,  B01D29/00 ,  C08J9/26 ,  B29C67/20 ,  B01D39/16 ,  B29K27/12 ,  B29K105/00 ,  B29K105/04

CPC classification number: B01D39/1661 ,  B01D29/0093 ,  B01D29/0095 ,  B01D39/1692 ,  B01D67/0004 ,  B01D67/003 ,  B01D71/36 ,  B29B7/88 ,  B29B11/12 ,  B29B13/02 ,  B29C67/202 ,  B29K2027/12 ,  B29K2105/0005 ,  B29K2105/04 ,  B29K2105/251 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0444 ,  C08J2327/12 ,  C08J2327/18 ,  E21B43/02 ,  E21B43/12 ,  E21B43/38

Abstract: A method for preparing a porous fluoropolymer precursor includes combining a fluoropolymer and a removable additive to form a composition, the removable additive having a thermal decomposition temperature greater than a sintering temperature of the fluoropolymer, compressing the composition to form a preform, and sintering the preform to form the porous fluoropolymer precursor. A method for preparing a porous fluoropolymer includes disposing the porous fluoropolymer precursor in a removing agent, contacting the removable additive with the removing agent, and removing, by the removing agent, the removable additive from the porous fluoropolymer precursor to form the porous fluoropolymer, wherein the porous fluoropolymer comprises a plurality of pores formed by removing the removable additive.

Abstract translation: 制备多孔含氟聚合物前体的方法包括将含氟聚合物和可除去的添加剂组合以形成组合物，该可除去的添加剂的热分解温度大于含氟聚合物的烧结温度，压缩该组合物以形成预成型体， 以形成多孔含氟聚合物前体。 一种制备多孔含氟聚合物的方法包括将多孔含氟聚合物前体置于除去剂中，使可除去的添加剂与去除剂接触，并由除去剂从多孔含氟聚合物前体除去可除去的添加剂以形成多孔含氟聚合物，其中 多孔含氟聚合物包括通过除去可除去添加剂而形成的多个孔。

公开(公告)号：US20140035201A1

公开(公告)日：2014-02-06

申请号：US13985457

申请日：2012-02-14

Applicant: Marcus Jarman-Smith ,  Mark Brady ,  John Devine ,  Keith Cartwright

Inventor： Marcus Jarman-Smith ,  Mark Brady ,  John Devine ,  Keith Cartwright

IPC: B29C45/00

CPC classification number: B29C45/0001 ,  A61L27/46 ,  C08J3/201 ,  C08J3/203 ,  C08J9/0066 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2371/12 ,  C08K3/32 ,  C08K2003/325 ,  C08L71/00

Abstract: There are provided methods of producing a component incorporating a bioactive material. In one embodiment the method comprises: (a) using a screw extruder to mix a polymeric material (I) with a bioactive material (II) and melt the polymeric material (I); and (b) making a component by moulding; and wherein the polymeric material (I) is of a type which includes: (i) phenyl moieties; (ii) ketone moieties; and (iii) ether moieties. Also provided are components comprising a polymeric material and a bioactive material.

Abstract translation: 提供了生产包含生物活性材料的组分的方法。 在一个实施方案中，该方法包括：（a）使用螺杆挤出机将聚合材料（I）与生物活性材料（II）混合并熔化聚合材料（I）; 和（b）通过模塑制成组分; 并且其中所述聚合物材料（I）是一种类型，其包括：（i）苯基部分; （ii）酮部分; 和（iii）醚部分。 还提供了包含聚合物材料和生物活性材料的组分。

公开(公告)号：US20120323339A1

公开(公告)日：2012-12-20

申请号：US13518669

申请日：2010-12-23

Applicant: Beatriz Olalde Graells ,  María Jesús Jurado Oñate

Inventor： Beatriz Olalde Graells ,  María Jesús Jurado Oñate

IPC: A61L27/56 ,  B29C67/20 ,  C08J9/28 ,  B32B5/18 ,  A61F2/28

CPC classification number: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2201/0446 ,  C08J2201/052 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249986 ,  C08L71/00

Abstract: The present invention refers to a porous PEEK-type polymer article comprising a porous PEEK-type polymer structure and presenting at least a trimodal pore distribution. The invention describes a process for the production of said porous PEEK-type polymer article comprising: a) contacting a PEEK-type polymer with a composition comprising at least a organic solvent, b) heating at a temperature at which the PEEK-type polymer is dissolved, c) adding at least a porogen agent, d) cooling the mixture obtained in c) at a temperature at least equal or lower than the temperature at which the PEEK-type polymer precipitates, e) forming said cooled mixture into a shaped article, f) removing the organic solvent and the porogen agent, and g) recovering the PEEK-type polymer article.

Abstract translation: 本发明涉及包含多孔PEEK型聚合物结构并呈现至少三峰孔分布的多孔PEEK型聚合物制品。 本发明描述了一种生产所述多孔PEEK型聚合物制品的方法，包括：a）使PEEK型聚合物与至少包含有机溶剂的组合物接触，b）在PEEK型聚合物为 溶解，c）至少加入致孔剂，d）在至少等于或低于PEEK型聚合物沉淀的温度的温度下冷却c）中得到的混合物，e）将所述冷却的混合物形成成型制品 ，f）除去有机溶剂和致孔剂，g）回收PEEK型聚合物制品。

公开(公告)号：US20120272866A1

公开(公告)日：2012-11-01

申请号：US13456878

申请日：2012-04-26

Applicant: Chung-Lin Wang ,  Wei-Yuan Chen

Inventor： Chung-Lin Wang ,  Wei-Yuan Chen

IPC: A61L31/14 ,  B29D11/00

CPC classification number: C08J9/26 ,  C08J2201/0444 ,  C08J2333/10

Abstract: Contact lenses with pores having high oxygen permeability and a manufacturing method thereof. The manufacturing method comprises the steps of uniformly mixing water-soluble salts and the formula of contact lenses having hydrophilic monomers to form a mixed formula; molding and forming the mixed formula to obtain contact lenses; dissolving and dialyzing the water-soluble salts by a water solution so as to form a plurality of pores with a predetermined diameter on a surface and in the interior of the contact lenses. The diameter of pore size has an allowable range between 0.03 μm and 0.05 μm such that the contact lenses with high oxygen permeability can be obtained.

Abstract translation: 具有高氧渗透性的孔的隐形眼镜及其制造方法。 该制造方法包括以下步骤：将具有亲水性单体的水溶性盐和隐形眼镜配方混合形成混合配方; 模制和形成混合配方以获得隐形眼镜; 通过水溶液溶解和透析水溶性盐，以在隐形眼镜的表面和内部形成具有预定直径的多个孔。 孔径的直径为0.03μm〜0.05μm的允许范围，可以得到透氧性高的隐形眼镜。