公开(公告)号：US20210261602A1

公开(公告)日：2021-08-26

申请号：US17261313

申请日：2019-07-19

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas TONKS ,  Navasona KRISHNAN ,  Andreas GRILL

IPC: C07J43/00 ,  C07D401/12 ,  C07D213/38

Abstract: Compounds of formula: are described herein. The compounds selectively complex copper and are therefore useful both abiotically for measuring and detecting small amounts of copper and, in biological systems, for treating diseases associated with inappropriate copper levels, such as Wilson's disease and gastric cancer.

公开(公告)号：US20210254064A1

公开(公告)日：2021-08-19

申请号：US17170047

申请日：2021-02-08

Applicant: Cold Spring Harbor Laboratory

Inventor： Gregory J. Hannon ,  Sihem Cheloufi

IPC: C12N15/113 ,  C12N15/11

Abstract: Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2 because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules.

公开(公告)号：US11033570B2

公开(公告)日：2021-06-15

申请号：US16465083

申请日：2017-12-01

Applicant: Cold Spring Harbor Laboratory ,  Ionis Pharmaceuticals, Inc.

Inventor： Allen Tingjin Yu ,  David L. Spector ,  Frank Rigo ,  Susan M. Freier ,  Jan Bergmann ,  Carmen Berasain

IPC: A61K31/713 ,  C12N15/113 ,  A61K9/00 ,  A61K31/7125 ,  A61K45/06

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of Inc05 in a cell or individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cancer in an individual.

公开(公告)号：US20210156847A1

公开(公告)日：2021-05-27

申请号：US17044913

申请日：2019-04-02

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  COLD SPRING HARBOR LABORATORY

Inventor： Anthony K.L. Leung ,  Yoshinari Ando ,  Robert L McPherson ,  Mohsen Badiee ,  Elad Elkayam

IPC: G01N33/533 ,  C12P19/30 ,  C12P19/34 ,  C07H21/00 ,  C12P21/00 ,  C07K9/00 ,  C12Q1/6811

Abstract: Described is ELTA (Enzymatic Labeling of Terminal ADP-ribose) to label free, protein-conjugated, or nucleic acid-conjugated ADP-ribose monomer and polymers at their 2′-OH termini. When coupled with different chemical analogs, ELTA can be used for various applications including fluorescence-based biophysical measurement of PAR-protein interaction, detection of PAR length from cells, and enrichment of ADP-ribosylated peptides for mass spectrometry identification.

公开(公告)号：US20200376018A1

公开(公告)日：2020-12-03

申请号：US16708739

申请日：2019-12-10

Applicant: Biogen MA Inc. ,  Cold Spring Harbor Laboratory

Inventor： C. Frank Bennett ,  Gene Hung ,  Frank Rigo ,  Adrian R. Krainer ,  Yimin Hua ,  Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng ,  Katherine W. Klinger

IPC: A61K31/7088 ,  C12N15/113

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

公开(公告)号：US20200323898A1

公开(公告)日：2020-10-15

申请号：US16767280

申请日：2018-11-27

Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER ,  COLD SPRING HARBOR LABORATORY

Inventor： Scott Lowe ,  Lingbo Zhang ,  Chichao Chen

IPC: A61K31/7105 ,  A61K9/00 ,  G01N33/68 ,  C12Q1/48 ,  A61P35/02

Abstract: The present disclosure relates generally to methods for ameliorating or treating acute myeloid leukemia (AML). In particular, the present technology relates to administering a therapeutically effective amount of one or more compositions that inhibit the vitamin B6 pathway to a subject diagnosed with, or at risk for AML.

公开(公告)号：US20200299705A1

公开(公告)日：2020-09-24

申请号：US16092862

申请日：2017-04-07

Applicant: Cold Spring Harbor Laboratory

Inventor： Zachary Lippman ,  Sebastian Soyk ,  Soon-Ju Park

IPC: C12N15/82 ,  A01H5/08 ,  C12N9/22

Abstract: Described herein is a florigen pathway toolkit that comprises mutations in genes in the florigen pathway in Solanaceae, such as mutations in genes in the florigen pathway in tomatoes, that are useful to quantitatively modulate or adjust the balance of opposing flowering signals to customize and improve shoot architecture and flowering (flowering time) for tomato breeding, particularly for fresh market tomato breeding.

公开(公告)号：US10647983B2

公开(公告)日：2020-05-12

申请号：US14916561

申请日：2014-09-04

Applicant: Cold Spring Harbor Laboratory

Inventor： Adrian Krainer ,  Isabel Aznarez ,  Tomoki Nomakuchi

IPC: C12N15/11 ,  A61K31/713 ,  C12Q1/6883 ,  A61K31/4245 ,  A61K31/726 ,  C07H21/02

Abstract: The present disclosure relates to compositions and methods for inhibiting nonsense-mediated mRNA decay in a gene-specific manner, for example in the treatment of diseases or disorders caused by nonsense mutations.

公开(公告)号：US20190241901A1

公开(公告)日：2019-08-08

申请号：US16311439

申请日：2017-06-29

Applicant: Cold Spring Harbor Laboratory ,  Cambridge Enterprise Limited

Inventor： Rob Martienssen ,  Charles Underwood ,  Ian Henderson

IPC: C12N15/82 ,  C12N15/113

CPC classification number: C12N15/8261 ,  A01H1/02 ,  C12N15/113 ,  C12N15/8218 ,  Y02A40/146

Abstract: The present disclosure provides methods for increasing meiotic recombination in crop plants, as well as plants and seeds produced by such methods.

公开(公告)号：US10266840B2

公开(公告)日：2019-04-23

申请号：US15067641

申请日：2016-03-11

Applicant: The United States of America, as represented by the Secretary of Agriculture ,  Cold Spring Harbor Laboratory

Inventor： Zhanguo Xin ,  Gloria B. Burow ,  Chad M Hayes ,  John J. Burke ,  Doreen Ware ,  Yinping Jiao

IPC: C12N15/29 ,  C12N15/82

Abstract: The present disclosure provides nucleic acids that confer a multi-seeded phenotype when expressed in plants and uses thereof.