公开(公告)号：US20070021827A1

公开(公告)日：2007-01-25

申请号：US11535529

申请日：2006-09-27

Applicant: David Lowe ,  Erik Eli ,  Jeff Pappas ,  Howard Huang ,  Anton Clifford ,  Kevin Kang

Inventor： David Lowe ,  Erik Eli ,  Jeff Pappas ,  Howard Huang ,  Anton Clifford ,  Kevin Kang

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2210/0076 ,  A61F2230/0043 ,  A61F2230/0054

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

Abstract translation: 内置假体，例如支架，包括至少一个环形元件，所述至少一个环形元件由第一组支柱构件限定，所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部，并且具有轮廓以提供至少两个挠曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接，并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地，提供至少一个或多个另外的环形元件，每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在连接位置处纵向对齐并连接。 优选地，每个连接位置包括脚部延伸部，例如通过在纵向相邻的环形元件之间的重叠图案，或者通过在它们之间延伸的连接器。

公开(公告)号：US20060004041A1

公开(公告)日：2006-01-05

申请号：US11120502

申请日：2005-05-03

Applicant: Christopher Cummings ,  David Lowe ,  William Ripka

Inventor： Christopher Cummings ,  David Lowe ,  William Ripka

IPC: A61K31/4709 ,  C07D43/02 ,  C07D41/02

CPC classification number: C07D217/02 ,  A61K31/47 ,  C07D217/06 ,  C07D217/08 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.

Abstract translation: 本发明涉及能抑制组蛋白脱乙酰酶（HDAC）的一类小分子异羟肟酸化合物。 本发明还涉及本发明的异羟肟酸HDAC抑制剂化合物的制备方法，它们是N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物，以及它们掺入药物组合物和给药方法中。 本发明还涉及可以用于本领域已知的筛选方法中的异羟肟酸HDAC抑制剂化合物文库的N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物。

公开(公告)号：US20050260724A1

公开(公告)日：2005-11-24

申请号：US11105259

申请日：2005-04-13

Applicant: Arie Ben-Bassat ,  Fateme Sariaslani ,  Lisa Huang ,  Ranjan Patnaik ,  David Lowe

Inventor： Arie Ben-Bassat ,  Fateme Sariaslani ,  Lisa Huang ,  Ranjan Patnaik ,  David Lowe

IPC: C12N1/21 ,  C12P7/40 ,  C12P7/42 ,  C12P13/22

CPC classification number: C12P7/42 ,  C12P7/40

Abstract: Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.

Abstract translation: 提供了对羟基肉桂酸（pHCA）和肉桂酸（CA）的微生物生产方法。 生产酪氨酸或苯丙氨酸的微生物分别在酪氨酸裂解酶或苯丙氨酸铵裂解酶的存在下生长，其中部分发酵在碱性pH下完成。 与仅在生理pH下的发酵相比，该方法产生较高的产率和较高的对羟基肉桂酸（PHCA）和肉桂酸（CA）产率。

公开(公告)号：US20050148406A1

公开(公告)日：2005-07-07

申请号：US11069284

申请日：2005-02-28

Applicant: Steven Mahaffey ,  Thomas Greene ,  David Lowe

Inventor： Steven Mahaffey ,  Thomas Greene ,  David Lowe

IPC: A61M27/00 ,  A63B53/04 ,  G02B6/036 ,  G02B6/42

CPC classification number: A63B53/0466 ,  A63B60/02 ,  A63B2053/0433 ,  A63B2053/0491 ,  A63B2225/01

Abstract: A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.

公开(公告)号：US20050132422A1

公开(公告)日：2005-06-16

申请号：US10969894

申请日：2004-10-21

Applicant: David Lowe ,  Gerhard Koenig ,  Christopher Cummings

Inventor： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

IPC: A01K67/00 ,  A01K67/033 ,  C12N15/85 ,  G01N33/00

CPC classification number: A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C12N15/8509

Abstract: The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Iowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

Abstract translation: 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Aβ42肽的爱荷华突变体版本的转基因飞行物，以及表达Tau蛋白和人Abeta42爱荷华双重转基因飞蝇 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

公开(公告)号：US06890267B2

公开(公告)日：2005-05-10

申请号：US10798147

申请日：2004-03-11

Applicant: Steven J. Mahaffey ,  Thomas M. Greene ,  David Lowe

Inventor： Steven J. Mahaffey ,  Thomas M. Greene ,  David Lowe

IPC: A61M27/00 ,  A63B53/04 ,  G02B6/036 ,  G02B6/42

CPC classification number: A63B53/0466 ,  A63B60/02 ,  A63B2053/0433 ,  A63B2053/0491 ,  A63B2225/01

Abstract: A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.

公开(公告)号：US06860818B2

公开(公告)日：2005-03-01

申请号：US10379146

申请日：2003-03-04

Applicant: Steven J. Mahaffey ,  Thomas M. Greene ,  David Lowe

Inventor： Steven J. Mahaffey ,  Thomas M. Greene ,  David Lowe

IPC: A61M27/00 ,  A63B53/04 ,  G02B6/036 ,  G02B6/42

CPC classification number: A63B53/0466 ,  A63B60/02 ,  A63B2053/0433 ,  A63B2053/0491 ,  A63B2225/01

Abstract: A golf club head with low peripheral and rearward weighting includes C-shaped and annular weights connected with at least one of the rear and bottom surfaces, respectively, of the head. The weighting within the peripheral weights is adjustable between the heel, rear, and toe portions of the head to customize the weight distribution of the head in accordance with a golfer's swing. The added weight and its orientation increases the moment of inertia of the head and reduces the rotation thereof.

Abstract translation: 具有低外围和后加重的高尔夫球杆头包括分别与头部的后表面和底表面中的至少一个连接的C形和环形重物。 外围重量之间的重量可以在头部的后跟，后部和脚趾部分之间调节，以根据高尔夫球手的摆动来定制头部的重量分布。 增加的重量和其取向增加了头部的惯性矩并且减小了其旋转。

公开(公告)号：US06777823B1

公开(公告)日：2004-08-17

申请号：US09861739

申请日：2001-05-21

Applicant: Gail Roberts ,  Philip Keene ,  David Lowe ,  James Hunt ,  Joseph F. Pinkerton ,  David B. Clifton

Inventor： Gail Roberts ,  Philip Keene ,  David Lowe ,  James Hunt ,  Joseph F. Pinkerton ,  David B. Clifton

IPC: H02K718

CPC classification number: F01D15/10 ,  F02C6/14 ,  F05D2220/64 ,  F05D2250/82 ,  F05D2250/84 ,  H02K7/025 ,  H02K7/1823 ,  Y02E60/16

Abstract: A continuous power system assembly is provided that includes an integrated shaft-driven unit. The unit contains a turbine, an alternator, a flywheel and a feed pump, all of which are coupled to the shaft. During various modes of operation, any of the turbine, alternator or flywheel may provide the torque used to drive the shaft. When the alternator is not providing the necessary torque to drive the shaft, it is operated as a generator that provides back-up power to a load. The present invention also includes a unique nozzle design that improves the ease with the nozzles may be manufactured in comparison to known designs. The nozzle is manufactured as two halves which are mated as part of the manufacturing process. The individual nozzles may, because only half of the nozzle segments exist on either half of the nozzle block, be easily manufactured using conventional machining.

Abstract translation: 提供了连续的电力系统组件，其包括集成的轴驱动单元。 该单元包含涡轮机，交流发电机，飞轮和进料泵，所有这些都联接到轴上。 在各种操作模式下，涡轮机，交流发电机或飞轮中的任何一个可以提供用于驱动轴的扭矩。 当交流发电机不提供必要的扭矩来驱动轴时，它作为一个发电机运行，为负载提供备用电力。 本发明还包括独特的喷嘴设计，其改进了与已知设计相比可以制造喷嘴的容易性。 喷嘴被制造成两半，其被配合为制造过程的一部分。 由于只有一半的喷嘴段存在于喷嘴块的任一半上，所以各个喷嘴可以使用传统的加工容易地制造。

公开(公告)号：US6039894A

公开(公告)日：2000-03-21

申请号：US986196

申请日：1997-12-05

Applicant: Angel Sanjurjo ,  Kai-Hung Lau ,  David Lowe ,  Anastasia Canizales ,  Naixiong Jiang ,  Victor Wong ,  Liqiang Jiang ,  Luke V. Schneider ,  Naheed Mufti ,  Robert T. Rewick ,  Marie Johansson ,  Keith Kardos

Inventor： Angel Sanjurjo ,  Kai-Hung Lau ,  David Lowe ,  Anastasia Canizales ,  Naixiong Jiang ,  Victor Wong ,  Liqiang Jiang ,  Luke V. Schneider ,  Naheed Mufti ,  Robert T. Rewick ,  Marie Johansson ,  Keith Kardos

IPC: C09K11/00 ,  C09K11/08

CPC classification number: C09K11/08 ,  C09K11/00 ,  C09K11/0805 ,  C09K11/0827

Abstract: The invention relates to a method for producing activated, substantially monodisperse, phosphorescent particles and particles formed thereby. The method suspends substantially monodisperse, phosphor-precursor particles in a fluidizing gas and then introduces a reactive gas to contact the suspended phosphor-precursor particles. Heating the suspended phosphor-precursor particles to a reaction temperature then forms unactivated phosphorescent particles. In another embodiment, the phosphor-precursor particles may be heated to a reaction temperature where they decompose to form the unactivated phosphor particles. The unactivated phosphorescent particles suspended within the fluidizing gas are activated by heating the unactivated phosphorescent particles to an activation temperature forming activated, substantially monodisperse, phosphorescent particles.

Abstract translation: 本发明涉及一种生产活化的，基本上单分散的磷光颗粒和由此形成的颗粒的方法。 该方法将大部分单分散的荧光体前体颗粒悬浮在流化气体中，然后引入反应性气体以接触悬浮的荧光体前体颗粒。 将悬浮的荧光体前体颗粒加热至反应温度，然后形成未活化的磷光颗粒。 在另一个实施方案中，荧光体 - 前体颗粒可以被加热至其分解以形成未活化的荧光体颗粒的反应温度。 悬浮在流化气体中的未活化的磷光颗粒通过将未活化的磷光颗粒加热至形成活化的基本上单分散的磷光颗粒的活化温度来活化。

公开(公告)号：US6009473A

公开(公告)日：1999-12-28

申请号：US846715

申请日：1997-04-30

Applicant: David Lowe

Inventor： David Lowe

IPC: H04L5/14 ,  H04L12/20

CPC classification number: H04L5/1446 ,  Y02B60/31

Abstract: A method for sharing a resource among a plurality of clients is provided. A request is received by a client requesting access to a shared resource. A usage rate is determined for the client. The usage rate of clients are reduced by transmitting a request for a usage reduction to the clients. The request for the usage reduction is initiated independent of a receipt of a message from the clients whose usage rates are being reduced. If a requested usage reduction would reduce a client below a minimum usage rate, then the usage rate of the client is set to the minimum usage rate. The minimum usage rate can be established by the client or by configuration data. The usage rate of a non-real-time client is adjusted based on a uniform rate. If the uniform rate is higher than a maximum usage rate, then the usage rate of a non-real-time client is adjusted to the maximum usage rate. The maximum usage rate can be established by the client or by configuration data.

Abstract translation: 提供了一种用于在多个客户端之间共享资源的方法。 请求访问共享资源的客户端接收到请求。 确定客户端的使用率。 通过向客户端发送使用减少请求来减少客户端的使用率。 独立于从使用率降低的客户端的消息的接收开始执行使用减少的请求。 如果所请求的使用减少将使客户端降低到最低使用率之下，则将客户端的使用率设置为最小使用率。 最小使用率可以由客户端或配置数据建立。 非实时客户端的使用率根据均匀率进行调整。 如果统一率高于最大使用率，则将非实时客户端的使用率调整为最大使用率。 最大使用率可由客户端或配置数据建立。