公开(公告)号：US20130226078A1

公开(公告)日：2013-08-29

申请号：US13845398

申请日：2013-03-18

Applicant: Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

Inventor： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC: A61M5/172 ,  A61N1/36

CPC classification number: A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G16H20/10 ,  G16H20/40 ,  G16H50/20 ,  G16H50/30

Abstract: The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

Abstract translation: 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US08475388B2

公开(公告)日：2013-07-02

申请号：US12847711

申请日：2010-07-30

Applicant: Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Jaeho Kim ,  Kent Lee

Inventor： Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Jaeho Kim ,  Kent Lee

IPC: A61B5/08

CPC classification number: A61B5/4818 ,  A61B5/0205 ,  A61B5/4806 ,  A61B5/4809 ,  A61B5/7264

Abstract: Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.

Abstract translation: 用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。 使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。 与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。 确定呼吸模式的特征。 根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。 使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

公开(公告)号：US20130079842A1

公开(公告)日：2013-03-28

申请号：US13626399

申请日：2012-09-25

Applicant: Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

Inventor： Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

IPC: A61N1/36

CPC classification number: A61N1/3611 ,  A61N1/36053

Abstract: An apparatus comprises a physiologic sensing circuit and a control circuit. The physiologic sensing circuit is configured to sense an electrical respiration signal representative of respiration of a subject. The control circuit includes a respiration monitor circuit and a therapy circuit. The respiration monitor circuit is configured to extract a respiration parameter from the respiration signal and detect that a value of the respiration parameter is outside of a target value range for the respiration parameter. The therapy circuit is configured to deliver neural stimulation to the carotid sinus of the subject to stimulate respiration and to adjust respiration to maintain the value of the respiration parameter within the target value range.

Abstract translation: 一种装置包括生理感测电路和控制电路。 生理感测电路被配置为感测代表受试者呼吸的电呼吸信号。 控制电路包括呼吸监测电路和治疗电路。 呼吸监视器电路被配置为从呼吸信号中提取呼吸参数，并且检测呼吸参数的值在呼吸参数的目标值范围之外。 治疗电路被配置为将神经刺激递送到受试者的颈动脉窦以刺激呼吸并调节呼吸以将呼吸参数的值保持在目标值范围内。

公开(公告)号：US08204585B2

公开(公告)日：2012-06-19

申请号：US11312278

申请日：2005-12-20

Applicant: John D. Hatlestad ,  Marina Brockway ,  Yousufali Husaini Dalal ,  Loell Boyce Moon

Inventor： John D. Hatlestad ,  Marina Brockway ,  Yousufali Husaini Dalal ,  Loell Boyce Moon

IPC: A61B5/05

CPC classification number: A61B5/0535 ,  A61B5/0809 ,  A61B5/7207 ,  A61N1/36521 ,  A61N1/3684 ,  A61N1/3962

Abstract: Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.

Abstract translation: 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。

公开(公告)号：US20110201969A1

公开(公告)日：2011-08-18

申请号：US13024823

申请日：2011-02-10

Applicant: John D. Hatlestad ,  Tsz Ping Chan

Inventor： John D. Hatlestad ,  Tsz Ping Chan

IPC: A61B5/103

CPC classification number: A61N1/36542 ,  A61B5/1116 ,  A61B5/1117 ,  A61B5/1118 ,  A61B5/686 ,  A61B2560/0223 ,  A61B2562/0219 ,  A61N1/3925 ,  G01P15/18

Abstract: A device can include a multi-dimensional posture sensor that provides an electrical sensor output representative of alignment of first, second, and third non-parallel axes of the device with the gravitational field of the earth, and a processor that includes a calibration circuit and a posture circuit. The calibration circuit measures a first sensor output for the first device axis and a second sensor output for one of a second device axis while the subject is in a first specified posture, measures sensor outputs for the first, second, and third device axes while the subject is in a second specified posture, calculates one or more coordinate transformations, generates transformed sensor outputs using the coordinate transformations, and calibrates the posture sensor by calculating a calibration transformation using the first and second sensor outputs and the transformed sensor outputs. The posture circuit determines a subsequent posture of the subject using the posture sensor.

Abstract translation: 设备可以包括多维姿态传感器，其提供表示设备的第一，第二和第三非平行轴线与地球的重力场的对准的电传感器输出，以及包括校准电路和 姿势电路。 校准电路测量第一设备轴的第一传感器输出和第二设备轴的第二传感器输出，同时对象处于第一指定姿势，测量第一，第二和第三设备轴的传感器输出，同时 受试者处于第二指定姿势，计算一个或多个坐标变换，使用坐标变换生成变换的传感器输出，并且通过使用第一和第二传感器输出和变换的传感器输出计算校准变换来校准姿势传感器。 姿势电路使用姿态传感器来确定对象的后续姿势。

公开(公告)号：US07993280B2

公开(公告)日：2011-08-09

申请号：US12847645

申请日：2010-07-30

Applicant: Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

Inventor： Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

IPC: A61B5/08

CPC classification number: A61B5/091 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/411 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36521

Abstract: Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.

Abstract translation: 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。

公开(公告)号：US20100280564A1

公开(公告)日：2010-11-04

申请号：US12836441

申请日：2010-07-14

Applicant: Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

Inventor： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC: A61N1/02 ,  A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G06F19/00

Abstract: The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

Abstract translation: 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US07766842B2

公开(公告)日：2010-08-03

申请号：US11890404

申请日：2007-08-06

Applicant: Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeff E. Stahmann ,  Jaeho Kim ,  Kent Lee

Inventor： Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeff E. Stahmann ,  Jaeho Kim ,  Kent Lee

IPC: A61B5/00

CPC classification number: A61B5/4818 ,  A61B5/0205 ,  A61B5/4806 ,  A61B5/4809 ,  A61B5/7264

Abstract: Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.

Abstract translation: 用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。 使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。 与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。 确定呼吸模式的特征。 根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。 使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

公开(公告)号：US07744542B2

公开(公告)日：2010-06-29

申请号：US11379396

申请日：2006-04-20

Applicant: Thomas Piaget ,  Paul Huelskamp ,  Jeffrey E. Stahmann ,  John D. Hatlestad

Inventor： Thomas Piaget ,  Paul Huelskamp ,  Jeffrey E. Stahmann ,  John D. Hatlestad

IPC: A61B5/0205

CPC classification number: A61B5/0031 ,  A61B5/036 ,  A61B5/08 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/1459 ,  A61B5/4818 ,  A61B5/68 ,  A61B7/003 ,  A61B2560/0242

Abstract: A physiological sensor is located within the airway of the subject's body, such as for measuring barometric pressure and communicating this value to a blood pressure or other monitoring device, which can derive gauge pressure using the barometric pressure and a measured absolute pressure within the body. The physiological sensor may also detect one or more other physiological parameters such as air flow, sound, or a chemical property. It may be anchored within the airway with the ability to communicate wirelessly to one or more other medical devices, such as an implanted cardiac function management device. Methods of use are also described.

Abstract translation: 生理传感器位于受试者身体的气道内，例如用于测量大气压力并将该值传递到血压或其他监测装置，其可以使用大气压力和体内测量的绝对压力来导出表压。 生理传感器还可以检测一个或多个其它生理参数，例如气流，声音或化学性质。 它可以锚定在气道内，具有与一个或多个其它医疗装置（例如植入式心脏功能管理装置）无线通信的能力。 还描述了使用方法。

公开(公告)号：US20100152608A1

公开(公告)日：2010-06-17

申请号：US12537403

申请日：2009-08-07

Applicant: John D. HATLESTAD ,  Binh C. TRAN ,  Bin MI ,  Ronald W. HEIL, JR.

Inventor： John D. HATLESTAD ,  Binh C. TRAN ,  Bin MI ,  Ronald W. HEIL, JR.

IPC: A61B5/00 ,  A61B5/11

CPC classification number: A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

Abstract: An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.

Abstract translation: 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生 以周期性间隔代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。