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公开(公告)号:US12041983B2
公开(公告)日:2024-07-23
申请号:US16491803
申请日:2018-03-06
Applicant: SIMON FRASER UNIVERSITY
Inventor: Daniel Eamon Abram , Farid Golnaraghi , Gaofeng Gary Wang
IPC: A41D13/015 , A42B3/06 , A42B3/12 , B32B3/26 , B32B5/18 , B32B5/24 , B32B5/26 , B32B7/12 , B32B25/04 , B32B25/08 , B32B25/10 , B32B25/20 , B32B27/06 , B32B27/08 , B32B27/12 , A63B71/12
CPC classification number: A41D13/015 , A42B3/064 , A42B3/121 , A42B3/127 , B32B3/266 , B32B5/18 , B32B5/245 , B32B5/26 , B32B7/12 , B32B25/045 , B32B25/08 , B32B25/10 , B32B25/20 , B32B27/065 , B32B27/08 , B32B27/12 , A63B71/1225 , A63B2071/1233 , A63B2071/1241 , A63B2071/125 , A63B2071/1258 , A63B2071/1275 , A63B2071/1283 , A63B71/1291 , A63B2209/00 , B32B2250/05 , B32B2307/51 , B32B2307/56 , B32B2307/712 , B32B2307/724 , B32B2307/7265 , B32B2437/04 , B32B2571/00 , B32B2605/003
Abstract: Generally described, aspects of the disclosed subject matter are directed to impact mitigating membranes. In accordance with aspects of the present disclosure, the impact mitigating membranes generally include a laminar core having a first lamina and a second lamina coupled to the first lamina and configured to shift relative to the first lamina to dissipate kinetic energy resulting from an oblique impact force. The laminar core may include a lubricating layer or self-lubrication between the lamina to reduce friction. In general, the laminar core is surrounded by first and second encapsulating layers positioned adjacent each lamina. An anchoring attachment coupled to one or more of the first and second encapsulating layer and associating with the laminar core constrains relative lateral motion between the laminar core and the first and second encapsulating layers.
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公开(公告)号:US20230129710A1
公开(公告)日:2023-04-27
申请号:US17913920
申请日:2021-03-25
Applicant: Simon Fraser University , Merck, Sharp & Dohme Corp.
Inventor: Robert Britton , Adluri Bharanishashank , Michael Meanwell , Steven Silverman
IPC: C07H1/00 , C07H19/067
Abstract: The present invention relates to methods and intermediates for the synthesis of nucleosides and nucleoside analogues (NAs). More specifically, the present invention relates to methods of synthesizing nucleosides and NAs, using simple achiral materials by a ‘one-pot’ proline-catalyzed halogenation of a heteroaryl-substituted acetaldehyde together with a tandem enantioselective aldol reaction followed by a reduction or organometallic addition and cyclization (annulation) reaction involving halide displacement.
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公开(公告)号:US11434490B2
公开(公告)日:2022-09-06
申请号:US16608127
申请日:2018-04-23
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITÉ DE STRASBOURG , SIMON FRASER UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor: Michael Ryckelynck , Alexis Autour , Peter Unrau , Elena Dolgosheina , Sunny Chiu Yuk Jeng , Shanker Shyam Sundhar Panchapakesan , Amir Abdolahzadeh , Razvan Cojocaru , Adrian Ferré D'Amaré , Robert Trachman
IPC: C12N15/115 , C12Q1/68
Abstract: RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.
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公开(公告)号:US11276822B2
公开(公告)日:2022-03-15
申请号:US16618296
申请日:2018-06-01
Applicant: Simon Fraser University
Inventor: Loren Gregory Kaake
Abstract: A method of depositing a lateral pattern of a deposition material onto a substrate. The method comprises fabricating a laterally patterned deposition surface on the substrate having one or more deposition regions and one or more non-deposition regions. The method comprises depositing deposition material onto the deposition regions of the deposition surface to form a deposition structure comprising deposited regions and non-deposited regions. Depositing deposition material comprises dissolving the deposition material in a solvent to form a solution, introducing the deposition surface into fluid contact with the solution, varying a temperature of the solution, varying a pressure of the solution; and selectively heating the deposition regions to temperatures greater than the temperature of the solution to cause the deposition material to precipitate from the solution and deposit onto the deposition regions.
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公开(公告)号:US20200173516A1
公开(公告)日:2020-06-04
申请号:US16783221
申请日:2020-02-06
Applicant: SIMON FRASER UNIVERSITY
Inventor: Mohammad Mehdi NASERIMOJARAD , Mehrdad MOALLEM , Siamak ARZANPOUR
Abstract: A bicycle with a suspension system for a wheel of the bicycle, the suspension system including a smart fluid damper for dampening a movement of the wheel relative to the frame. The smart fluid damper includes a flow control element disposed within a cavity of the damper and configured to apply a field to a smart fluid within a fluid passage extending through the flow control element. The flow control element includes field barriers proximate the fluid passage to locally block and/or divert the field such that the field cannot pass therethrough. The field barriers are arranged to cause the field to criss-cross the fluid passage at multiple axial intervals along the fluid passage, thereby focusing the field within the fluid passage.
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96.
公开(公告)号:US20200076369A1
公开(公告)日:2020-03-05
申请号:US16562337
申请日:2019-09-05
Applicant: Simon Fraser University
Inventor: Zachary Raymond NUNN , Erol GIRT
Abstract: A magnetic structure is provided. The magnetic structure may have a first magnetic layer with a first magnetization direction, a second magnetic layer with a second magnetization direction and a coupling layer interposed between the first and second magnetic layers. The coupling layer may include at least one non-magnetic element and at least one magnetic element. The atomic ratio of the at least one non-magnetic element to the at least one magnetic element is (100-x):x, where x is an atomic concentration parameter. Atomic concentration parameter, x, may cause the first magnetic layer to be non-collinearly coupled to the second magnetic layer such that, in the absence of external magnetic field, the first magnetization direction is oriented at a non-collinear angle relative to the second magnetization direction.
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公开(公告)号:US20190382353A1
公开(公告)日:2019-12-19
申请号:US16321414
申请日:2017-07-29
Applicant: Simon Fraser University
Inventor: Steven Holdcroft , Jiantao Fan , Andrew Wright , Benjamin Britton , Thomas Weissbach , Timothy James Peckham , Jonathan William Ward
IPC: C07D233/64 , A61P31/00
Abstract: Provided herein are imidazolium polymers having steric hindrance at the 4-position of the imidazole moieties in the polymeric chain. The sterically-protected, N-methylated imidazolium polymers exhibit hydroxide stability in concentrated caustic solutions at elevated temperatures, such as at 100° C. and higher.
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公开(公告)号:US20190328233A1
公开(公告)日:2019-10-31
申请号:US16479025
申请日:2018-01-17
Applicant: Simon Fraser University
Inventor: Farid GOLNARAGHI , Majid SHOKOUFI
Abstract: A diffuse-optical-spectroscopy system and method for scanning human tissue. The system includes: (a) a handheld probe operable to emit electromagnetic radiation at one or more wavelengths corresponding to absorption associated with one or more human-tissue constituents, respectively, the handheld probe being operable to detect received electromagnetic radiation at each of the wavelengths; and (b) a processor operable to produce, in response to the received electromagnetic radiation, one or more cross-sectional images of the human tissue respectively associated with the wavelengths. The handheld probe includes first and second sources for emitting the electromagnetic radiation and one or more sensors for detecting the received electromagnetic radiation. The sensors are aligned along a first axis and face in an outward direction. The first and second sources are aligned along the first axis, face in the outward direction, and are disposed on either side of the sensors.
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公开(公告)号:US20190221246A1
公开(公告)日:2019-07-18
申请号:US16228725
申请日:2018-12-20
Applicant: Simon Fraser University
Inventor: Zachary Raymond NUNN , Erol GIRT
CPC classification number: G11C11/1673 , G01R33/093 , G01R33/098 , G01R33/1284 , G11C11/15 , G11C11/161 , G11C11/1675 , H01F1/015 , H01F1/017 , H01F10/3254 , H01F10/3272 , H01F10/329 , H01L43/08 , H01L43/10
Abstract: A magnetic device comprising having a first magnetic layer having a first magnetization direction, a second magnetic layer having a second magnetization direction, a first coupling layer interposed between the first and second magnetic layers, a third magnetic layer having a third magnetization direction, a first magnetoresistive layer interposed between the third magnetic layer and the second magnetic layer, and a circuit connected to one or more of the layers of the magnetic device by at least a pair of leads. The circuit is configured to determine a change in resistance between the pair of leads. The change in resistance is based at least in part on a change in an angular relationship between the third magnetization direction and the second magnetization direction caused by an external magnetic field or a current passing through at least a portion of the device.
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公开(公告)号:US20190128362A1
公开(公告)日:2019-05-02
申请号:US15801042
申请日:2017-11-01
Applicant: SIMON FRASER UNIVERSITY
Inventor: Mohammad Mehdi NASERIMOJARAD , Mehrdad MOALLEM , Siamak ARZANPOUR
Abstract: A smart fluid damper includes a damper body defining a cavity with smart fluid. A piston head is disposed within the cavity and is slidingly displaceable. A flow control element is disposed within the cavity. The flow control element includes a main body having a central core, and an outer housing that surrounds the main body and is spaced apart therefrom to define a fluid passage between the main body and the outer housing. The fluid passage extends axially through the main body to permit fluid flow therethrough. The central core includes an energizable coil operable to apply a field. A plurality of field barriers are provided, each operable to locally block the field generated by the energizable coil such that the field cannot pass directly therethrough. The field barriers are configured to focus the field within the fluid passage.
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