公开(公告)号：US11116971B2

公开(公告)日：2021-09-14

申请号：US16391362

申请日：2019-04-23

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Maria E. Bennett ,  Amorn Wongsarnpigoon ,  John Chae ,  Warren M. Grill ,  Kathryn Stager ,  Rosemary Zang

IPC: A61N1/36 ,  A61N1/05 ,  A61B17/34

Abstract: It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

公开(公告)号：US20210106829A1

公开(公告)日：2021-04-15

申请号：US17113460

申请日：2020-12-07

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs, II ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：USD904629S1

公开(公告)日：2020-12-08

申请号：US29651462

申请日：2018-08-16

Applicant: SPR Therapeutics, Inc.

Designer： Matthew G. deBock ,  Joseph W. Boggs, II ,  Matthew J. Wunzin ,  Robert B. Strother, Jr. ,  Devin Sell ,  Mark R. Stultz ,  Bradley A. Lewis

公开(公告)号：US10722715B2

公开(公告)日：2020-07-28

申请号：US15854206

申请日：2017-12-26

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：US10426959B2

公开(公告)日：2019-10-01

申请号：US15888338

申请日：2018-02-05

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II

IPC: A61N1/36 ,  A61N1/05

Abstract: Systems and methods make possible the placement of one or more electrode leads in a tissue region for providing functional and/or therapeutic stimulation to tissue. The systems and methods are adapted to provide the relief of pain.

公开(公告)号：US20190060642A1

公开(公告)日：2019-02-28

申请号：US16052089

申请日：2018-08-01

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Amorn Wongsarnpigoon ,  Matthew G. deBock ,  Meredith J. McGee ,  Devin Sell ,  Robert B. Strother

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  A61B17/34

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

公开(公告)号：US20180236222A1

公开(公告)日：2018-08-23

申请号：US15898889

申请日：2018-02-19

Applicant: SPR THERAPEUTICS, INC.

Inventor： Joseph W. Boggs ,  Rosemary H. Zang

IPC: A61N1/05 ,  A61N1/04

CPC classification number: A61N1/0551 ,  A61B5/061 ,  A61N1/0456 ,  A61N1/0502 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36071

Abstract: Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.

公开(公告)号：US20180078763A1

公开(公告)日：2018-03-22

申请号：US15822768

申请日：2017-11-27

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Robert B. Strother ,  Kathryn W. Stager ,  Jonathan L. Sakai ,  Amorn Wongsarnpigoon ,  Matthew deBock ,  Devin Sell ,  Meredith McGee

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/05 ,  G01R31/04 ,  H01R11/30 ,  H01R13/20

CPC classification number: A61N1/36017 ,  A61B2562/227 ,  A61N1/05 ,  A61N1/0502 ,  A61N1/0551 ,  A61N1/36021 ,  A61N1/375 ,  A61N1/3752 ,  G01R31/043 ,  H01R11/30 ,  H01R13/20 ,  H01R2201/12

Abstract: Neurostimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles and/or nerves inside the body and stimulus generators and/or recording instruments mounted on the surface of the skin or carried outside the body. The assembly affords maximum patient mobility and comfort through differentiated components having minimal profiles and connected by way of detachable and adjustable connections.

公开(公告)号：US20180078756A1

公开(公告)日：2018-03-22

申请号：US15822580

申请日：2017-11-27

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs, II ,  John Chae

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/08 ,  A61N1/02 ,  A61N1/04

CPC classification number: A61N1/0504 ,  A61N1/025 ,  A61N1/0456 ,  A61N1/0502 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36071

Abstract: Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.