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公开(公告)号：US09821023B2
公开(公告)日：2017-11-21
申请号：US14943885
申请日：2015-11-17
Inventor： Victor J. Hruby , Minying Cai
IPC: A61K38/12 , A61K38/10 , A61K47/24 , A61K9/00 , A61K9/107 , A61K9/70 , C07K14/68 , C07K14/685 , C07K14/72 , C07K7/08
CPC classification number: A61K38/12 , A61K9/0014 , A61K9/107 , A61K9/2004 , A61K9/7023 , A61K9/7084 , A61K38/10 , A61K47/24 , C07K7/08 , C07K14/68 , C07K14/685 , C07K14/723
Abstract: Methods of treating a central nervous system (CNS) disorder or mood disorder in a subject in need of such treatment are described. A therapeutically effective amount of a composition comprising a melanocortin 5 receptor (MC5R) peptide ligand in a pharmaceutically acceptable carrier is administered to the subject. The MC5R peptide ligand is a selective MC5R antagonist, in which administration thereof to the subject can treat the CNS disorder or mood disorder with clinical improvement observed in a relatively short time.
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公开(公告)号：US20170304372A1
公开(公告)日：2017-10-26
申请号：US15508409
申请日：2015-09-02
Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , THE HENRY M. JACKSON FOUDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： Won Jong Kim , María Auxilio Rendón-Espinosa , Magdalene Yh So , Maira Goytia , Ann Jerse , Dustin Higashi
Abstract: The present invention relates to compositions and methods for preventing and/or treating gonorrhea. In particular, the present invention provides compositions comprising an effective amount of a commensal species of Neisseria (e.g., an effective amount of an extract of a commensal species of Neisseria), wherein such compositions are capable of inhibiting the growth of Neisseria gonorrhoeae.
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公开(公告)号：US20170246632A1
公开(公告)日：2017-08-31
申请号：US15507616
申请日：2015-08-28
Applicant: Alberto C. Redaelli , Marco Rasponi , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventor： Marvin J. Slepian , Alberto C. Redaelli , Marco Rasponi , Danny Bluestein
CPC classification number: B01L3/502746 , A61B5/14546 , B01L2400/086 , G01N15/1056 , G01N33/5091 , G01N33/56966 , G01N33/56972 , G01N2015/1006 , G01N2800/224 , G01N2800/226
Abstract: Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.
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公开(公告)号：US20170245989A1
公开(公告)日：2017-08-31
申请号：US15492227
申请日：2017-04-20
Applicant: The Research Foundation for The State University of New York , The Arizona Board of Regents on Behalf of the University of Arizona
Inventor： Danny Bluestein , Thomas E. Claiborne , Marvin J. Slepian
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2415 , A61F2250/0036
Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
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公开(公告)号：US09746127B2
公开(公告)日：2017-08-29
申请号：US15030692
申请日：2014-10-21
Inventor： Roger P Angel , Brian Cuerden , Andrew R Whiteside
CPC classification number: F16M11/18 , F16M11/08 , F16M11/22 , F16M13/02 , F24S25/70 , F24S30/42 , F24S30/452 , F24S2030/133 , H02S20/32 , Y02E10/47
Abstract: An apparatus is disclosed for rotating equipment, like solar panels, about an axis. Tension and compression members, in a rigid structure, are employed in the apparatus to minimize weight and to maximize stiffness. The rotating equipment is attached to the upper end of a rotatable elongated compression member, rotatably supported at its lower end by a tri-pod base comprising three additional compression members. Six tension members extending up from the tripod base hold a flange through which passes the rotatable elongated compression member. Lateral forces on the rotatable equipment are transmitted to the tripod base through the six tension members. The apparatus is configured such that wind forces and torques on the rotated equipment are transmitted by the apparatus to ground supports. Solar panels supported by the apparatus may be held at a fixed tilt angle, or an additional mechanism may be provided for rotational about a second orthogonal axis.
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Patent Agency Ranking
公开(公告)号：US20170240271A1
公开(公告)日：2017-08-24
申请号：US15349745
申请日：2016-11-11
Inventor： HERMANN F. FASEL
CPC classification number: B64C21/10 , B64C21/04 , B64C21/08 , B64C23/06 , B64C30/00 , B64C2230/10 , B64C2230/26 , Y02T50/162 , Y02T50/166
Abstract: A system and method for controlling hypersonic boundary layer transition for a hypersonic flight vehicle are disclosed. The reduction or elimination of hot streaks that naturally occurs in the boundary layer transition process during hypersonic flight is achieved by utilizing various techniques. One such technique utilizes roughness elements to counteract streak development. The techniques for reducing or eliminating the streaks are tailored such that the nonlinear stages of transition are profoundly altered. This results in significant drag reduction, and consequently an increase in range of the vehicle, and also a reduction of the weight penalty due to the Thermal Protection Systems (TPS) as less protective material would be required, thus allowing for an increased payload and/or range of the vehicle.
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97.发明授权公开(公告)号：US09719134B2
公开(公告)日：2017-08-01
申请号：US14512256
申请日：2014-10-10
Inventor： Jeong-Yeol Yoon , David J. You
CPC classification number: C12Q1/686 , B01L7/52 , G01N35/1009 , G01N2035/1037
Abstract: Disclosed herein are automated systems for performing various biochemical and molecular biological procedures, including processor-controlled execution of protocols involving multiple steps performed in, on, or with liquid microdroplets. Example protocols are the various Polymerase Chain Reaction (PCR) protocols, but the subject systems are not limited to performing PCR protocols. Formation of a microdroplet of the sample for use in the described systems is achieved by bringing an amount of the sample into contact with a hydrophobic milieu, such as a superhydrophobic surface or hydrophobic liquid.
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公开(公告)号：US20170188815A1
公开(公告)日：2017-07-06
申请号：US15461893
申请日：2017-03-17
Applicant: UNIVERSITY OF ROCHESTER , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventor： Jinxin Huang , Jannick P. Rolland , Eric Clarkson , Matthew Kupinski
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/102 , A61B3/113
Abstract: Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical estimator, which determines the thickness of the lipid and/or aqueous layers at a nanometer resolution based on the inputted spectrum and other information, such as information about a laser intensity noise, Poisson noise, and dark noise associated with the OCT.
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公开(公告)号：US09681800B2
公开(公告)日：2017-06-20
申请号：US13791665
申请日：2013-03-08
CPC classification number: A61B3/0285 , A61B3/1015 , A61B3/103 , A61F2/1635 , G02B3/14 , G02B5/32
Abstract: A phoropter having a line of sight for a viewer to see through comprises a lens system in the line of sight, wherein a shape or focal length of at least one lens in the lens system is controllable by means of an electrical signal, electrical field or current. Wavefront sensors of the phoropter detect local tilts of light wavefronts emerging from the eye and generate output signals that are used for controlling the shape or focal length of the at least one lens. Holographic or diffractive elements are used to collect light scattered from an eye of the viewer and image the scattered light to the wavefront sensors. Preferably one or more of the holographic or diffractive elements are away from the line of sight of the viewer. To use the phoropter, light is passed to the lens system, and light scattered by the eye is collected by the holographic or diffractive elements and imaged onto the wavefront sensors.
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公开(公告)号：US20170166580A1
公开(公告)日：2017-06-15
申请号：US15325320
申请日：2015-07-10
Inventor： Jon Njardarson , Jun Isoe , Roger Miesfeld
IPC: C07D495/04 , A01N43/90
CPC classification number: C07D495/04 , A01N43/90
Abstract: Compounds that inhibit digestion in blood-ingesting pests are described herein. In one embodiment, the compounds described herein block entry of blood into the midgut and thereby inhibit digestion and nutrient processing. In another embodiment, the compounds described herein prevent pathogens contained in the blood meal from entering the midgut where they could cross the epithelial cell layer and infect the mosquito. The compounds can be administered to a population of blood-ingesting pests, such as mosquitos, directly or indirectly in an effective amount to prevent mosquitoes from transmitting diseases such as malaria, dengue fever, West Nile virus and lymphatic filariasis. Preferably, the compounds are lethal to blood-ingesting pests. The compounds can be combined with one or more excipients to prepare compositions.
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